Pharmacokinetics of sevoflurane uptake into the brain and body

C. C. Lu, C. S. Tsai, S. T. Ho, W. Y. Chen, C. S. Wong, J. J. Wang, O. Y.P. Hu, C. Y. Lin

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The aim of this study was to investigate the pharmacokinetics of sevoflurane uptake into the brain and body by comparing sevoflurane concentrations in internal jugular-bulb blood (Jsev), arterial blood (Asev) and pulmonary arterial blood (PAsev) over a fixed inspired sevoflurane concentration. Ten patients (aged 51-73 years), undergoing coronary artery bypass grafting surgery were enrolled in this study. They were anaesthetised using a constant 3.5% inspired sevoflurane concentration (CIsev) during the first hour of anaesthesia. During constant volume-controlled ventilation, we measured CIsev and end-tidal sevoflurane (CEsev) using infrared analysis. The sevoflurane concentration in the blood was analysed using gas chromatography, and cardiac output was measured using an Opti-Q pulmonary artery catheter. We found that it took 40 min for the brain concentration to equilibrate with arterial blood (Asev). Both CIsev-CEsev and Asev-PAsev gradients persisted during the study period. There was no further uptake of sevoflurane into the brain after 40 min; however, there was near-constant uptake into the body.

Original languageEnglish
Pages (from-to)951-956
Number of pages6
JournalAnaesthesia
Volume58
Issue number10
DOIs
Publication statusPublished - Oct 1 2003
Externally publishedYes

Fingerprint

Pharmacokinetics
Brain
Coronary Artery Bypass
sevoflurane
Cardiac Output
Gas Chromatography
Pulmonary Artery
Ventilation
Neck
Catheters
Anesthesia
Lung

Keywords

  • Anaesthetics, volatile: sevoflurane
  • Brain

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Lu, C. C., Tsai, C. S., Ho, S. T., Chen, W. Y., Wong, C. S., Wang, J. J., ... Lin, C. Y. (2003). Pharmacokinetics of sevoflurane uptake into the brain and body. Anaesthesia, 58(10), 951-956. https://doi.org/10.1046/j.1365-2044.2003.03346.x

Pharmacokinetics of sevoflurane uptake into the brain and body. / Lu, C. C.; Tsai, C. S.; Ho, S. T.; Chen, W. Y.; Wong, C. S.; Wang, J. J.; Hu, O. Y.P.; Lin, C. Y.

In: Anaesthesia, Vol. 58, No. 10, 01.10.2003, p. 951-956.

Research output: Contribution to journalArticle

Lu, CC, Tsai, CS, Ho, ST, Chen, WY, Wong, CS, Wang, JJ, Hu, OYP & Lin, CY 2003, 'Pharmacokinetics of sevoflurane uptake into the brain and body', Anaesthesia, vol. 58, no. 10, pp. 951-956. https://doi.org/10.1046/j.1365-2044.2003.03346.x
Lu CC, Tsai CS, Ho ST, Chen WY, Wong CS, Wang JJ et al. Pharmacokinetics of sevoflurane uptake into the brain and body. Anaesthesia. 2003 Oct 1;58(10):951-956. https://doi.org/10.1046/j.1365-2044.2003.03346.x
Lu, C. C. ; Tsai, C. S. ; Ho, S. T. ; Chen, W. Y. ; Wong, C. S. ; Wang, J. J. ; Hu, O. Y.P. ; Lin, C. Y. / Pharmacokinetics of sevoflurane uptake into the brain and body. In: Anaesthesia. 2003 ; Vol. 58, No. 10. pp. 951-956.
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