Pharmacokinetics of fexofenadine in healthy Taiwanese volunteers

Yen An Chen, Kuang Yang Hsu

Research output: Contribution to journalArticle

Abstract

The aim of presented study was to assess pharmacokinetic properties of fexofenadine in Taiwanese volunteers. Thirty-three healthy male subjects received 180mg fexofenadine. Blood samples were drawn at appropriate times. Drug concentrations of fexofenadine were measured by a LC/MS/MS method. Non-compartmental models were applied to describe the pharmacokinetic characters of fexofenadine. After oral administration of fexofenadine, the Tmaxwas 1.90±0.81h. The Cmaxwas 703.76±298.94ng/mL and AUC0-∞was 4582.52±1812.59hxng/mL. The elimination half-life of fexofenadine was 12.18±3.61h. One of the most important determinants was to prove the similar results in the pharmacokinetics of fexofenadine in Taiwan subjects compared with the reported data of other ethnic origin.

Original languageEnglish
Pages (from-to)1261-1264
Number of pages4
JournalPakistan Journal of Pharmaceutical Sciences
Volume27
Issue number5
Publication statusPublished - Sep 1 2014

Keywords

  • Fexofenadine
  • LC/MS/MS
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pharmaceutical Science

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