Pharmacokinetics of (-)-epicatechin in rabbits

Yen An Chen, Kuang Yang Hsu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this study was to investigate the pharmacokinetics of (-)-epicatechin (EC) in rabbits after intravenous, intraperitoneal, and oral administration. A two-compartment model was used to describe the pharmacokinetics of EC after intravenous administration. EC showed dose-independent pharmacokinetics after intravenous administration. In addition, the area under the concentration-time curve was proportional to the dose over the range 5-25 mg/kg. After intraperitoneal administration of 25 mg/kg, a high percentage of EC escaped from first-pass hepatic elimination. After oral administration of 50 mg/kg, there was a great variation in the pharmacokinetics, and the mean oral bioavailability of EC was 4%. There was no significant difference in the elimination rate constants in all treatments (p>0.05). In conclusion, after intravenous, intraperitoneal, and oral administration of EC, the EC exhibits dose-independent pharmacokinetics in rabbits. The first-pass effect did not participate in the low oral bioavailability. Base on the results of the present study, the other factors may contribute the low oral bioavailability.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalArchives of Pharmacal Research
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2009

Keywords

  • (-)-Epicatechin
  • Bioavailability
  • Pharmacokinetics

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Organic Chemistry

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