Pharmacokinetics and nephrotoxicity of aristolochic acid in rabbits

Shih Ming Chen, Mei Yu Fan, Chia Chi Tseng, Yih Ho, Kuang Yang Hsu

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Aristolochic acids (AAs) which exist in plants of the genus Aristolochia are the toxins responsible for aristolochic acid nephropathy (AAN). To investigate the pharmacokinetics and nephrotoxicity of AAs, rabbits were used in this study. The plasma concentrations of the main components of AAs, aristolochic acid I (AA I) and aristolochic acid II (AA II), were determined by a validated high-performance liquid chromatographic method. After intravenous administration of different doses (0.25, 0.5, 1.0, and 2.0 mg/kg) of aristolochic acid sodium (AANa) to 4 respective groups of rabbits (n=6 for each dose), linear relationships between the doses of AA I and AA II and the area under the plasma concentration curve (AUC) were found to exist (p

Original languageEnglish
Pages (from-to)180-188
Number of pages9
JournalToxicon
Volume50
Issue number2
DOIs
Publication statusPublished - Aug 2007

Keywords

  • Aristolochic acids nephropathy (AAN)
  • Nephrotoxicity
  • Pharmacokinetic
  • Rabbit

ASJC Scopus subject areas

  • Toxicology

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