Pharmacokinetic properties of recombinant porcine growth hormone in pigs

O. Y.P. Hu, W. C. Chang, T. S. Yang

Research output: Contribution to journalArticlepeer-review

Abstract

The plasma pharmacokinetic profile of recombinant porcine growth hormone (rpGH) was studied in six healthy gilts after a rapid single i.v. injection of 250 μg/kg rpGH. The linear pharmacokinetic properties of rpGH were investigated by giving four different doses of the hormone at intervals of 2 days. The plasma rpGH concentration was determined by radioimmunoassay with a lowest detection limit of 50 pg/ml. Plasma levels of rpGH were fitted to a three-compartment open model; a triexponential decrease in plasma rpGH with a rather long mean terminal half-life of 40.22 ± 5.623 min was obtained in these pigs. Linear pharmacokinetic properties of rpGH were confirmed in the additional pig that received doses between 25 and 250 μg/kg rpGH. The small volume of distribution, 0.029 ± 0.003 l/kg, indicated that most of the injected rpGH was confined to the blood and probably lymph. The total plasma clearance of rpGH was 31.80 ± 2.802 ml/h x kg. The results not only contribute significantly to our knowledge about rpGH pharmacokinetics, but also to future studies for the rational design of optimal dosage regimens and the development of a controlled-release device for rpGH.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalPharmacology
Volume50
Issue number1
Publication statusPublished - Jan 1 1995
Externally publishedYes

Keywords

  • Half-life
  • Linear pharmacokinetic property
  • Pharmacokinetics
  • Radioimmunoassay
  • Recombinant porcine growth hormone

ASJC Scopus subject areas

  • Pharmacology

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