Pharmacokinetic properties of ranitidine in Chinese people

O. Y.P. Hu, L. H. Pao, P. H. Chung, H. S. Tang

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2 Citations (Scopus)

Abstract

The pharmacokinetics and relative bioavailability of two different formulated ranitidine tablets were examined in 12 healthy young Chinese males at one week intervals in a randomized crossover design. Both ranitidine plasma and urine concentrations were measured by a sensitive, accurate and specific High Performance Liquid Chromatography method. No bioavailability differences were found between Glaxo's and Veteran's ranitidine products. However, larger apparent volume of distribution, higher total oral clearance and higher non-renal clearance were observed in Chinese. Further studies are needed to elucidate a higher rantidine dosage may be required for Chinese to achieve the desired plasma level.

Original languageEnglish
Pages (from-to)328-335
Number of pages8
JournalActa Gastro-Enterologica Belgica
Volume54
Issue number5-6
Publication statusPublished - Dec 1 1991
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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    Hu, O. Y. P., Pao, L. H., Chung, P. H., & Tang, H. S. (1991). Pharmacokinetic properties of ranitidine in Chinese people. Acta Gastro-Enterologica Belgica, 54(5-6), 328-335.