Abstract
The pharmacokinetics and relative bioavailability of two different formulated injectable gentamicin products were examined i.m. in 12 healthy young Chinese men at intervals of 1 week in a randomized cross-over design. Serum concentrations of gentamicin were measured by a fluorescence polarization immunoassay (FPIA) method sensitive to 0.01 μg/ml. The urine concentration of gentamicin was measured by the USP bioassay method. The serum protein binding of gentamicin was determined by an ultracentrifuge method and the free drug concentration was also determined by FPIA. No differences were found in bioavailability between gentamicin products of two manufacturers (Schering and Veterans). However, longer half-life, larger volume of distribution, slower distribution rate and much higher percentage of gentamicin excreted in the urine were observed in Chinese subjects than in Caucasians. Despite the longer half-life which was observed in Chinese, the total body clearance of the antibiotic in Chinese was about the same as that of Caucasians, therefore, the same gentamicin dosage may be needed for Chinese to achieve the desired serum level.
| Original language | English |
|---|---|
| Pages (from-to) | 85-89 |
| Number of pages | 5 |
| Journal | International Journal of Pharmaceutics |
| Volume | 53 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jul 1 1989 |
| Externally published | Yes |
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Keywords
- Bioavailability
- Chinese
- Gentamicin
- Pharmacokinetics
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Pharmacokinetic properties of intramuscular gentamicin in Chinese subjects. / Hu, Oliver Yoa Pu; Liou, Wen Shyong; Su, Te Jung; Chiam, Shu Fei; Lai, Jin Shing; Chu, Mong Ling; Chung, Ping Hong.
In: International Journal of Pharmaceutics, Vol. 53, No. 1, 01.07.1989, p. 85-89.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacokinetic properties of intramuscular gentamicin in Chinese subjects
AU - Hu, Oliver Yoa Pu
AU - Liou, Wen Shyong
AU - Su, Te Jung
AU - Chiam, Shu Fei
AU - Lai, Jin Shing
AU - Chu, Mong Ling
AU - Chung, Ping Hong
PY - 1989/7/1
Y1 - 1989/7/1
N2 - The pharmacokinetics and relative bioavailability of two different formulated injectable gentamicin products were examined i.m. in 12 healthy young Chinese men at intervals of 1 week in a randomized cross-over design. Serum concentrations of gentamicin were measured by a fluorescence polarization immunoassay (FPIA) method sensitive to 0.01 μg/ml. The urine concentration of gentamicin was measured by the USP bioassay method. The serum protein binding of gentamicin was determined by an ultracentrifuge method and the free drug concentration was also determined by FPIA. No differences were found in bioavailability between gentamicin products of two manufacturers (Schering and Veterans). However, longer half-life, larger volume of distribution, slower distribution rate and much higher percentage of gentamicin excreted in the urine were observed in Chinese subjects than in Caucasians. Despite the longer half-life which was observed in Chinese, the total body clearance of the antibiotic in Chinese was about the same as that of Caucasians, therefore, the same gentamicin dosage may be needed for Chinese to achieve the desired serum level.
AB - The pharmacokinetics and relative bioavailability of two different formulated injectable gentamicin products were examined i.m. in 12 healthy young Chinese men at intervals of 1 week in a randomized cross-over design. Serum concentrations of gentamicin were measured by a fluorescence polarization immunoassay (FPIA) method sensitive to 0.01 μg/ml. The urine concentration of gentamicin was measured by the USP bioassay method. The serum protein binding of gentamicin was determined by an ultracentrifuge method and the free drug concentration was also determined by FPIA. No differences were found in bioavailability between gentamicin products of two manufacturers (Schering and Veterans). However, longer half-life, larger volume of distribution, slower distribution rate and much higher percentage of gentamicin excreted in the urine were observed in Chinese subjects than in Caucasians. Despite the longer half-life which was observed in Chinese, the total body clearance of the antibiotic in Chinese was about the same as that of Caucasians, therefore, the same gentamicin dosage may be needed for Chinese to achieve the desired serum level.
KW - Bioavailability
KW - Chinese
KW - Gentamicin
KW - Pharmacokinetics
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UR - http://www.scopus.com/inward/citedby.url?scp=0024321729&partnerID=8YFLogxK
U2 - 10.1016/0378-5173(89)90366-9
DO - 10.1016/0378-5173(89)90366-9
M3 - Article
AN - SCOPUS:0024321729
VL - 53
SP - 85
EP - 89
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
SN - 0378-5173
IS - 1
ER -