Pharmacokinetic properties of intramuscular gentamicin in Chinese subjects

Oliver Yoa Pu Hu, Wen Shyong Liou, Te Jung Su, Shu Fei Chiam, Jin Shing Lai, Mong Ling Chu, Ping Hong Chung

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The pharmacokinetics and relative bioavailability of two different formulated injectable gentamicin products were examined i.m. in 12 healthy young Chinese men at intervals of 1 week in a randomized cross-over design. Serum concentrations of gentamicin were measured by a fluorescence polarization immunoassay (FPIA) method sensitive to 0.01 μg/ml. The urine concentration of gentamicin was measured by the USP bioassay method. The serum protein binding of gentamicin was determined by an ultracentrifuge method and the free drug concentration was also determined by FPIA. No differences were found in bioavailability between gentamicin products of two manufacturers (Schering and Veterans). However, longer half-life, larger volume of distribution, slower distribution rate and much higher percentage of gentamicin excreted in the urine were observed in Chinese subjects than in Caucasians. Despite the longer half-life which was observed in Chinese, the total body clearance of the antibiotic in Chinese was about the same as that of Caucasians, therefore, the same gentamicin dosage may be needed for Chinese to achieve the desired serum level.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume53
Issue number1
DOIs
Publication statusPublished - Jul 1 1989
Externally publishedYes

Fingerprint

Gentamicins
Pharmacokinetics
Fluorescence Polarization Immunoassay
Biological Availability
Half-Life
Urine
Veterans
Serum
Protein Binding
Biological Assay
Cross-Over Studies
Blood Proteins
Anti-Bacterial Agents
Injections
Pharmaceutical Preparations

Keywords

  • Bioavailability
  • Chinese
  • Gentamicin
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Hu, O. Y. P., Liou, W. S., Su, T. J., Chiam, S. F., Lai, J. S., Chu, M. L., & Chung, P. H. (1989). Pharmacokinetic properties of intramuscular gentamicin in Chinese subjects. International Journal of Pharmaceutics, 53(1), 85-89. https://doi.org/10.1016/0378-5173(89)90366-9

Pharmacokinetic properties of intramuscular gentamicin in Chinese subjects. / Hu, Oliver Yoa Pu; Liou, Wen Shyong; Su, Te Jung; Chiam, Shu Fei; Lai, Jin Shing; Chu, Mong Ling; Chung, Ping Hong.

In: International Journal of Pharmaceutics, Vol. 53, No. 1, 01.07.1989, p. 85-89.

Research output: Contribution to journalArticle

Hu, OYP, Liou, WS, Su, TJ, Chiam, SF, Lai, JS, Chu, ML & Chung, PH 1989, 'Pharmacokinetic properties of intramuscular gentamicin in Chinese subjects', International Journal of Pharmaceutics, vol. 53, no. 1, pp. 85-89. https://doi.org/10.1016/0378-5173(89)90366-9
Hu, Oliver Yoa Pu ; Liou, Wen Shyong ; Su, Te Jung ; Chiam, Shu Fei ; Lai, Jin Shing ; Chu, Mong Ling ; Chung, Ping Hong. / Pharmacokinetic properties of intramuscular gentamicin in Chinese subjects. In: International Journal of Pharmaceutics. 1989 ; Vol. 53, No. 1. pp. 85-89.
@article{83fd1ade4ce94544b4861b609eea7f92,
title = "Pharmacokinetic properties of intramuscular gentamicin in Chinese subjects",
abstract = "The pharmacokinetics and relative bioavailability of two different formulated injectable gentamicin products were examined i.m. in 12 healthy young Chinese men at intervals of 1 week in a randomized cross-over design. Serum concentrations of gentamicin were measured by a fluorescence polarization immunoassay (FPIA) method sensitive to 0.01 μg/ml. The urine concentration of gentamicin was measured by the USP bioassay method. The serum protein binding of gentamicin was determined by an ultracentrifuge method and the free drug concentration was also determined by FPIA. No differences were found in bioavailability between gentamicin products of two manufacturers (Schering and Veterans). However, longer half-life, larger volume of distribution, slower distribution rate and much higher percentage of gentamicin excreted in the urine were observed in Chinese subjects than in Caucasians. Despite the longer half-life which was observed in Chinese, the total body clearance of the antibiotic in Chinese was about the same as that of Caucasians, therefore, the same gentamicin dosage may be needed for Chinese to achieve the desired serum level.",
keywords = "Bioavailability, Chinese, Gentamicin, Pharmacokinetics",
author = "Hu, {Oliver Yoa Pu} and Liou, {Wen Shyong} and Su, {Te Jung} and Chiam, {Shu Fei} and Lai, {Jin Shing} and Chu, {Mong Ling} and Chung, {Ping Hong}",
year = "1989",
month = "7",
day = "1",
doi = "10.1016/0378-5173(89)90366-9",
language = "English",
volume = "53",
pages = "85--89",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Pharmacokinetic properties of intramuscular gentamicin in Chinese subjects

AU - Hu, Oliver Yoa Pu

AU - Liou, Wen Shyong

AU - Su, Te Jung

AU - Chiam, Shu Fei

AU - Lai, Jin Shing

AU - Chu, Mong Ling

AU - Chung, Ping Hong

PY - 1989/7/1

Y1 - 1989/7/1

N2 - The pharmacokinetics and relative bioavailability of two different formulated injectable gentamicin products were examined i.m. in 12 healthy young Chinese men at intervals of 1 week in a randomized cross-over design. Serum concentrations of gentamicin were measured by a fluorescence polarization immunoassay (FPIA) method sensitive to 0.01 μg/ml. The urine concentration of gentamicin was measured by the USP bioassay method. The serum protein binding of gentamicin was determined by an ultracentrifuge method and the free drug concentration was also determined by FPIA. No differences were found in bioavailability between gentamicin products of two manufacturers (Schering and Veterans). However, longer half-life, larger volume of distribution, slower distribution rate and much higher percentage of gentamicin excreted in the urine were observed in Chinese subjects than in Caucasians. Despite the longer half-life which was observed in Chinese, the total body clearance of the antibiotic in Chinese was about the same as that of Caucasians, therefore, the same gentamicin dosage may be needed for Chinese to achieve the desired serum level.

AB - The pharmacokinetics and relative bioavailability of two different formulated injectable gentamicin products were examined i.m. in 12 healthy young Chinese men at intervals of 1 week in a randomized cross-over design. Serum concentrations of gentamicin were measured by a fluorescence polarization immunoassay (FPIA) method sensitive to 0.01 μg/ml. The urine concentration of gentamicin was measured by the USP bioassay method. The serum protein binding of gentamicin was determined by an ultracentrifuge method and the free drug concentration was also determined by FPIA. No differences were found in bioavailability between gentamicin products of two manufacturers (Schering and Veterans). However, longer half-life, larger volume of distribution, slower distribution rate and much higher percentage of gentamicin excreted in the urine were observed in Chinese subjects than in Caucasians. Despite the longer half-life which was observed in Chinese, the total body clearance of the antibiotic in Chinese was about the same as that of Caucasians, therefore, the same gentamicin dosage may be needed for Chinese to achieve the desired serum level.

KW - Bioavailability

KW - Chinese

KW - Gentamicin

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=0024321729&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024321729&partnerID=8YFLogxK

U2 - 10.1016/0378-5173(89)90366-9

DO - 10.1016/0378-5173(89)90366-9

M3 - Article

AN - SCOPUS:0024321729

VL - 53

SP - 85

EP - 89

JO - International Journal of Pharmaceutics

JF - International Journal of Pharmaceutics

SN - 0378-5173

IS - 1

ER -