Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis

Hsing Fang Lu, Po Hsin Chou, Gan Hong Lin, Wan Hsuan Chou, Shih Tien Wang, Wirawan Adikusuma, Eko Mugiyanto, Kuo Sheng Hung, Wei Chiao Chang

Research output: Contribution to journalArticlepeer-review

Abstract

Osteoporosis is characterized by decreased bone mineral density and increased risk of fracture. Raloxifene is one of the treatments of osteoporosis. However, the responses were variable among patients. Previous studies revealed that the genetic variants are involved in the regulation of treatment outcomes. To date, studies that evaluate the influence of genes across all genome on the raloxifene treatment response are still limited. In this study, a total of 41 postmenopausal osteoporosis patients under regular raloxifene treatment were included. Gene-based analysis using MAGMA was applied to investigate the genetic association with the bone mineral density response to raloxifene at the lumbar spine or femoral neck site. Results from gene-based analysis indicated several genes (GHRHR, ABHD8, and TMPRSS6) related to the responses of raloxifene. Besides, the pathways of iron ion homeostasis, osteoblast differentiation, and platelet morphogenesis were enriched which implies that these pathways might be relatively susceptible to raloxifene treatment outcome. Our study provided a novel insight into the response to raloxifene.
Original languageEnglish
Article number8855423
Pages (from-to)8855423
JournalDisease Markers
Volume2020
DOIs
Publication statusPublished - 2020

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

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