Pharmacogenetics of cutaneous flushing response to niacin/laropiprant combination in Hong Kong Chinese patients with dyslipidemia

Miao Hu, Ya Ling Yang, Paul Chan, Brian Tomlinson

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: Cutaneous flushing with niacin varies between individuals and is substantially reduced by concomitant laropiprant. We investigated associations between baseline phenotypes and selected genotypes and flushing symptoms with niacin/laropiprant combination. Patients & methods: Flushing symptoms were quantified in 196 Chinese dyslipidaemic patients treated with niacin/laropiprant, and associations with phenotypes and selected polymorphisms were analyzed. Results: Moderate or severe flushing was associated with lower body mass index and the rs2279238 polymorphism in the LXRα on multivariate regression analysis and these factors accounted for 18.9% of the total variance. Conclusion: Lower body mass index and the LXRα polymorphism appear to be associated with flushing symptoms with niacin/laropiprant. Whether these findings can be applicable to other niacin formulations without laropiprant needs to be verified.

Original languageEnglish
Pages (from-to)1387-1397
Number of pages11
JournalPharmacogenomics
Volume16
Issue number12
DOIs
Publication statusPublished - Aug 1 2015

Keywords

  • flushing
  • laropiprant
  • LXRα
  • niacin

ASJC Scopus subject areas

  • Pharmacology
  • Genetics
  • Molecular Medicine

Fingerprint Dive into the research topics of 'Pharmacogenetics of cutaneous flushing response to niacin/laropiprant combination in Hong Kong Chinese patients with dyslipidemia'. Together they form a unique fingerprint.

Cite this