Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats

Chi Rei Wu, Li Wei Lin, Chia Ling Hsieh, Wen Hsin Wang, Yung Ta Lin, Ming Tsuen Hsieh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Aim: Our previous study indicated petroleum ether layer of Cnidium monnieri L. Cuss. (CM) and its ingredient osthole could alleviate scopolamine-induced amnesia in female rats. Materials and methods: Hence, this study was desired to investigate the mechanism of the ameliorating effects of petroleum ether layer of CM on the performance impairment of inhibitory avoidance task and Morris water maze induced by scopolamine in male rats. Results: CM at 0.1-0.6 g/kg orally administered 60 min before the training trial ameliorated the scopolamine-induced performance impairment on inhibitory avoidance learning and water maze in male rats. Only adrenalectomy but not peripheral cholinergic antagonist scopolamine methylbromide and catecholaminergic neurotoxin 6-hydroxydopamine blocked the ameliorating effects of CM on scopolamine-induced performance impairment in rats. Conclusion: Therefore, we demonstrated that the ameliorating effects of CM on scopolamine-induced performance impairment may be related to activating the adrenal gland and central acetylcholingeric neuron, instead of peripheral nervous system.

Original languageEnglish
Pages (from-to)403-407
Number of pages5
JournalJournal of Ethnopharmacology
Volume117
Issue number3
DOIs
Publication statusPublished - May 22 2008
Externally publishedYes

Fingerprint

Cnidium
Scopolamine Hydrobromide
Amnesia
Adrenal Glands
N-Methylscopolamine
Avoidance Learning
Water
Oxidopamine
Adrenalectomy
Peripheral Nervous System
Neurotoxins
Cholinergic Antagonists
naphtha
Neurons

Keywords

  • Adrenalectomy
  • Cnidium monnieri L. Cuss.
  • Inhibitory avoidance task
  • Morris water maze
  • Scopolamine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats. / Wu, Chi Rei; Lin, Li Wei; Hsieh, Chia Ling; Wang, Wen Hsin; Lin, Yung Ta; Hsieh, Ming Tsuen.

In: Journal of Ethnopharmacology, Vol. 117, No. 3, 22.05.2008, p. 403-407.

Research output: Contribution to journalArticle

Wu, Chi Rei ; Lin, Li Wei ; Hsieh, Chia Ling ; Wang, Wen Hsin ; Lin, Yung Ta ; Hsieh, Ming Tsuen. / Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats. In: Journal of Ethnopharmacology. 2008 ; Vol. 117, No. 3. pp. 403-407.
@article{5234c78cbac1462f8dabbb2c1e1b67b7,
title = "Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats",
abstract = "Aim: Our previous study indicated petroleum ether layer of Cnidium monnieri L. Cuss. (CM) and its ingredient osthole could alleviate scopolamine-induced amnesia in female rats. Materials and methods: Hence, this study was desired to investigate the mechanism of the ameliorating effects of petroleum ether layer of CM on the performance impairment of inhibitory avoidance task and Morris water maze induced by scopolamine in male rats. Results: CM at 0.1-0.6 g/kg orally administered 60 min before the training trial ameliorated the scopolamine-induced performance impairment on inhibitory avoidance learning and water maze in male rats. Only adrenalectomy but not peripheral cholinergic antagonist scopolamine methylbromide and catecholaminergic neurotoxin 6-hydroxydopamine blocked the ameliorating effects of CM on scopolamine-induced performance impairment in rats. Conclusion: Therefore, we demonstrated that the ameliorating effects of CM on scopolamine-induced performance impairment may be related to activating the adrenal gland and central acetylcholingeric neuron, instead of peripheral nervous system.",
keywords = "Adrenalectomy, Cnidium monnieri L. Cuss., Inhibitory avoidance task, Morris water maze, Scopolamine",
author = "Wu, {Chi Rei} and Lin, {Li Wei} and Hsieh, {Chia Ling} and Wang, {Wen Hsin} and Lin, {Yung Ta} and Hsieh, {Ming Tsuen}",
year = "2008",
month = "5",
day = "22",
doi = "10.1016/j.jep.2008.02.013",
language = "English",
volume = "117",
pages = "403--407",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats

AU - Wu, Chi Rei

AU - Lin, Li Wei

AU - Hsieh, Chia Ling

AU - Wang, Wen Hsin

AU - Lin, Yung Ta

AU - Hsieh, Ming Tsuen

PY - 2008/5/22

Y1 - 2008/5/22

N2 - Aim: Our previous study indicated petroleum ether layer of Cnidium monnieri L. Cuss. (CM) and its ingredient osthole could alleviate scopolamine-induced amnesia in female rats. Materials and methods: Hence, this study was desired to investigate the mechanism of the ameliorating effects of petroleum ether layer of CM on the performance impairment of inhibitory avoidance task and Morris water maze induced by scopolamine in male rats. Results: CM at 0.1-0.6 g/kg orally administered 60 min before the training trial ameliorated the scopolamine-induced performance impairment on inhibitory avoidance learning and water maze in male rats. Only adrenalectomy but not peripheral cholinergic antagonist scopolamine methylbromide and catecholaminergic neurotoxin 6-hydroxydopamine blocked the ameliorating effects of CM on scopolamine-induced performance impairment in rats. Conclusion: Therefore, we demonstrated that the ameliorating effects of CM on scopolamine-induced performance impairment may be related to activating the adrenal gland and central acetylcholingeric neuron, instead of peripheral nervous system.

AB - Aim: Our previous study indicated petroleum ether layer of Cnidium monnieri L. Cuss. (CM) and its ingredient osthole could alleviate scopolamine-induced amnesia in female rats. Materials and methods: Hence, this study was desired to investigate the mechanism of the ameliorating effects of petroleum ether layer of CM on the performance impairment of inhibitory avoidance task and Morris water maze induced by scopolamine in male rats. Results: CM at 0.1-0.6 g/kg orally administered 60 min before the training trial ameliorated the scopolamine-induced performance impairment on inhibitory avoidance learning and water maze in male rats. Only adrenalectomy but not peripheral cholinergic antagonist scopolamine methylbromide and catecholaminergic neurotoxin 6-hydroxydopamine blocked the ameliorating effects of CM on scopolamine-induced performance impairment in rats. Conclusion: Therefore, we demonstrated that the ameliorating effects of CM on scopolamine-induced performance impairment may be related to activating the adrenal gland and central acetylcholingeric neuron, instead of peripheral nervous system.

KW - Adrenalectomy

KW - Cnidium monnieri L. Cuss.

KW - Inhibitory avoidance task

KW - Morris water maze

KW - Scopolamine

UR - http://www.scopus.com/inward/record.url?scp=42749097642&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42749097642&partnerID=8YFLogxK

U2 - 10.1016/j.jep.2008.02.013

DO - 10.1016/j.jep.2008.02.013

M3 - Article

C2 - 18400431

AN - SCOPUS:42749097642

VL - 117

SP - 403

EP - 407

JO - Journal of Ethnopharmacology

JF - Journal of Ethnopharmacology

SN - 0378-8741

IS - 3

ER -