Perspectives on the role of isoliquiritigenin in cancer

Kai Lee Wang, Ying Chun Yu, Shih Min Hsia

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)

Abstract

Isoliquiritigenin (20,40,4-trihydroxychalcone, ISL), one of the most important bioactive compounds with a chalcone structure, is derived from licorice root. Licorice is commonly known as Glycyrrhiza, including Glycyrrhiza uralensis, Glycyrrhiza radix, and Glycyrrhiza glabra, which are generally available in common foods and Chinese herbal medicines based on a wide variety of biological functions and pharmacological effects, and its derivative (ISL) is utilized as a food additive and adjunct disease treatment. In this review, we summarized the progress over the last 10 years in the targeted pathways and molecular mechanisms of ISL that are involved in the regulation of the onset and progression of different types of cancers.

Original languageEnglish
Article number115
Pages (from-to)1-37
Number of pages37
JournalCancers
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 1 2021

Keywords

  • Apoptosis
  • Cancer
  • Cell signaling
  • Isoliquiritigenin

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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