Personal exposure to particulate matter and inflammation among patients with periodontal disease

Tsung Han Yang, Shin Ichi Masumi, Shao Ping Weng, Hua Wei Chen, Hsiao Chi Chuang, Kai Jen Chuang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The association between particulate air pollution and high-sensitivity C-reactive protein (hs-CRP) has been well documented in epidemiological studies. Periodontitis has been linked to elevated hs-CRP levels in recent studies. It is still unknown whether patients with periodontal infections are more susceptible to particulate air pollution. The aim of this study was to investigate whether particles with aerodynamic diameters of less than 2.5μm (PM2.5) had greater effects on increasing hs-CRP among patients with periodontal infections compared to periodontally healthy individuals. We conducted a cross-sectional study on two panels of adult subjects, 100 adult patients with chronic periodontitis and 100 periodontally healthy adults, in order to evaluate the association between particulate matter (PM) and hs-CRP. We collected blood samples from each subject, measured hs-CRP and monitored average exposure to PM2.5 over 24h four times during 2010 to 2012. We used mixed-effects models to estimate the association between PM2.5 and hs-CRP and adjusted for cardiovascular risk factors. We found that a 10μg/m3 increase in PM2.5 was associated with a 3.22% (95% confidence interval, CI: 1.21, 5.23; p2.5 in patients was significantly higher than the effect in healthy participants. In the healthy adult panel, a 10μg/m3 increase in PM2.5 was associated with a 1.17% (95% CI: 0.54, 1.80; p3 increase in PM2.5 was associated with a 9.62% (95% CI: 7.05, 12.19; p2.5 was associated with increases in hs-CRP among adult subjects. The presence of periodontal disease led to a considerably increased effect magnitude by more than eight fold.

Original languageEnglish
Pages (from-to)585-589
Number of pages5
JournalScience of the Total Environment
Volume502
DOIs
Publication statusPublished - Jan 1 2015

Fingerprint

Particulate Matter
Periodontal Diseases
C-Reactive Protein
particulate matter
Inflammation
Proteins
protein
Air Pollution
Air pollution
atmospheric pollution
Chronic Periodontitis
Periodontitis
Infection
exposure
risk factor
confidence interval
aerodynamics
Epidemiologic Studies
Aerodynamics
Healthy Volunteers

Keywords

  • Air pollution
  • Epidemiology
  • Inflammation
  • Particulate matter
  • Periodontitis

ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution
  • Waste Management and Disposal
  • Environmental Engineering
  • Medicine(all)

Cite this

Personal exposure to particulate matter and inflammation among patients with periodontal disease. / Yang, Tsung Han; Masumi, Shin Ichi; Weng, Shao Ping; Chen, Hua Wei; Chuang, Hsiao Chi; Chuang, Kai Jen.

In: Science of the Total Environment, Vol. 502, 01.01.2015, p. 585-589.

Research output: Contribution to journalArticle

@article{8554d205a3614b8591a3d3625f597643,
title = "Personal exposure to particulate matter and inflammation among patients with periodontal disease",
abstract = "The association between particulate air pollution and high-sensitivity C-reactive protein (hs-CRP) has been well documented in epidemiological studies. Periodontitis has been linked to elevated hs-CRP levels in recent studies. It is still unknown whether patients with periodontal infections are more susceptible to particulate air pollution. The aim of this study was to investigate whether particles with aerodynamic diameters of less than 2.5μm (PM2.5) had greater effects on increasing hs-CRP among patients with periodontal infections compared to periodontally healthy individuals. We conducted a cross-sectional study on two panels of adult subjects, 100 adult patients with chronic periodontitis and 100 periodontally healthy adults, in order to evaluate the association between particulate matter (PM) and hs-CRP. We collected blood samples from each subject, measured hs-CRP and monitored average exposure to PM2.5 over 24h four times during 2010 to 2012. We used mixed-effects models to estimate the association between PM2.5 and hs-CRP and adjusted for cardiovascular risk factors. We found that a 10μg/m3 increase in PM2.5 was associated with a 3.22{\%} (95{\%} confidence interval, CI: 1.21, 5.23; p2.5 in patients was significantly higher than the effect in healthy participants. In the healthy adult panel, a 10μg/m3 increase in PM2.5 was associated with a 1.17{\%} (95{\%} CI: 0.54, 1.80; p3 increase in PM2.5 was associated with a 9.62{\%} (95{\%} CI: 7.05, 12.19; p2.5 was associated with increases in hs-CRP among adult subjects. The presence of periodontal disease led to a considerably increased effect magnitude by more than eight fold.",
keywords = "Air pollution, Epidemiology, Inflammation, Particulate matter, Periodontitis",
author = "Yang, {Tsung Han} and Masumi, {Shin Ichi} and Weng, {Shao Ping} and Chen, {Hua Wei} and Chuang, {Hsiao Chi} and Chuang, {Kai Jen}",
year = "2015",
month = "1",
day = "1",
doi = "10.1016/j.scitotenv.2014.09.081",
language = "English",
volume = "502",
pages = "585--589",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

TY - JOUR

T1 - Personal exposure to particulate matter and inflammation among patients with periodontal disease

AU - Yang, Tsung Han

AU - Masumi, Shin Ichi

AU - Weng, Shao Ping

AU - Chen, Hua Wei

AU - Chuang, Hsiao Chi

AU - Chuang, Kai Jen

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The association between particulate air pollution and high-sensitivity C-reactive protein (hs-CRP) has been well documented in epidemiological studies. Periodontitis has been linked to elevated hs-CRP levels in recent studies. It is still unknown whether patients with periodontal infections are more susceptible to particulate air pollution. The aim of this study was to investigate whether particles with aerodynamic diameters of less than 2.5μm (PM2.5) had greater effects on increasing hs-CRP among patients with periodontal infections compared to periodontally healthy individuals. We conducted a cross-sectional study on two panels of adult subjects, 100 adult patients with chronic periodontitis and 100 periodontally healthy adults, in order to evaluate the association between particulate matter (PM) and hs-CRP. We collected blood samples from each subject, measured hs-CRP and monitored average exposure to PM2.5 over 24h four times during 2010 to 2012. We used mixed-effects models to estimate the association between PM2.5 and hs-CRP and adjusted for cardiovascular risk factors. We found that a 10μg/m3 increase in PM2.5 was associated with a 3.22% (95% confidence interval, CI: 1.21, 5.23; p2.5 in patients was significantly higher than the effect in healthy participants. In the healthy adult panel, a 10μg/m3 increase in PM2.5 was associated with a 1.17% (95% CI: 0.54, 1.80; p3 increase in PM2.5 was associated with a 9.62% (95% CI: 7.05, 12.19; p2.5 was associated with increases in hs-CRP among adult subjects. The presence of periodontal disease led to a considerably increased effect magnitude by more than eight fold.

AB - The association between particulate air pollution and high-sensitivity C-reactive protein (hs-CRP) has been well documented in epidemiological studies. Periodontitis has been linked to elevated hs-CRP levels in recent studies. It is still unknown whether patients with periodontal infections are more susceptible to particulate air pollution. The aim of this study was to investigate whether particles with aerodynamic diameters of less than 2.5μm (PM2.5) had greater effects on increasing hs-CRP among patients with periodontal infections compared to periodontally healthy individuals. We conducted a cross-sectional study on two panels of adult subjects, 100 adult patients with chronic periodontitis and 100 periodontally healthy adults, in order to evaluate the association between particulate matter (PM) and hs-CRP. We collected blood samples from each subject, measured hs-CRP and monitored average exposure to PM2.5 over 24h four times during 2010 to 2012. We used mixed-effects models to estimate the association between PM2.5 and hs-CRP and adjusted for cardiovascular risk factors. We found that a 10μg/m3 increase in PM2.5 was associated with a 3.22% (95% confidence interval, CI: 1.21, 5.23; p2.5 in patients was significantly higher than the effect in healthy participants. In the healthy adult panel, a 10μg/m3 increase in PM2.5 was associated with a 1.17% (95% CI: 0.54, 1.80; p3 increase in PM2.5 was associated with a 9.62% (95% CI: 7.05, 12.19; p2.5 was associated with increases in hs-CRP among adult subjects. The presence of periodontal disease led to a considerably increased effect magnitude by more than eight fold.

KW - Air pollution

KW - Epidemiology

KW - Inflammation

KW - Particulate matter

KW - Periodontitis

UR - http://www.scopus.com/inward/record.url?scp=84907965031&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907965031&partnerID=8YFLogxK

U2 - 10.1016/j.scitotenv.2014.09.081

DO - 10.1016/j.scitotenv.2014.09.081

M3 - Article

C2 - 25302445

AN - SCOPUS:84907965031

VL - 502

SP - 585

EP - 589

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -