Abstract

Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged

Original languageEnglish
Pages (from-to)800-808
Number of pages9
JournalBipolar Disorders
Volume16
Issue number8
DOIs
Publication statusPublished - Dec 1 2014

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Leptin
Bipolar Disorder
Insulin
Depression
Inflammation
Immunomodulation
Weight Gain
Insulin Resistance

Keywords

  • Bipolar depression
  • High-sensitivity C-reactive protein (hs-CRP)
  • Inflammation
  • Interleukin-1 receptor antagonist (IL-1Ra)
  • sIL-6R
  • Soluble interleukin-2 receptor (sIL-2R)
  • Soluble tumor necrosis factor receptor 1 (sTNF-R1)

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

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title = "Persistent inflammation and its relationship to leptin and insulin in phases of bipolar disorder from acute depression to full remission",
abstract = "Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged",
keywords = "Bipolar depression, High-sensitivity C-reactive protein (hs-CRP), Inflammation, Interleukin-1 receptor antagonist (IL-1Ra), sIL-6R, Soluble interleukin-2 receptor (sIL-2R), Soluble tumor necrosis factor receptor 1 (sTNF-R1)",
author = "Tsai, {Shang Ying} and Chung, {Kuo Hsuan} and Shou-Hung Huang and Chen, {Pao Huan} and Lee, {Hsin Chien} and Kuo, {Chian Jue}",
year = "2014",
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T1 - Persistent inflammation and its relationship to leptin and insulin in phases of bipolar disorder from acute depression to full remission

AU - Tsai, Shang Ying

AU - Chung, Kuo Hsuan

AU - Huang, Shou-Hung

AU - Chen, Pao Huan

AU - Lee, Hsin Chien

AU - Kuo, Chian Jue

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged

AB - Objective: A proinflammatory phase with various immunomodulatory mechanisms has been noted in bipolar mania and major depression. Weight gain and increased production of leptin may be associated with immunomodulation and insulin resistance in bipolar disorder. However, immunomodulation and its linkage with leptin and insulin in the depressive episode of bipolar disorder remain unclear. We investigated alterations in inflammatory markers and their relationship with leptin and insulin levels in patients with phases of bipolar disorder from acute depression to full remission. Methods: Thirty-two physically healthy bipolar I depressed patients aged

KW - Bipolar depression

KW - High-sensitivity C-reactive protein (hs-CRP)

KW - Inflammation

KW - Interleukin-1 receptor antagonist (IL-1Ra)

KW - sIL-6R

KW - Soluble interleukin-2 receptor (sIL-2R)

KW - Soluble tumor necrosis factor receptor 1 (sTNF-R1)

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