10 Citations (Scopus)

Abstract

In this study, the permeation of two biological compounds through a novel porous poly(l-lactic acid) (PLLA) microtube array membrane (MTAM) were investigated. Glucose and bovine serum albumin (BSA) were permeated through PLLA MTAMs to simulate the transportation of biological compounds during nerve regeneration. PLLA MTAMs with various porous wall structures were prepared by the addition of porogen. Electrospinning process was conducted to produce solid MTAMs. Porous MTAMs were obtained by washing off the porogen. Permeation of BSA and glucose were investigated by utilizing a home-made permeation unit at 37 °C for both inflow and outflow. The permeation rate increased with the porosity of the MTAM; with the inflow rate faster than the outflow rate for both compounds suggesting a diffusive permeation. The rate of BSA permeation was faster than that of glucose. Fourier transfer infra-red (FTIR) spectra of the two compounds permeated through PLLA membranes were obtained to elucidate this phenomena.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalEuropean Polymer Journal
Volume67
DOIs
Publication statusPublished - Jun 1 2015

Fingerprint

lactic acid
Lactic acid
Permeation
Lactic Acid
membranes
Membranes
Bovine Serum Albumin
albumins
glucose
serums
Glucose
porous walls
washing
Electrospinning
nerves
regeneration
Washing
infrared spectra
Porosity
Infrared radiation

Keywords

  • Electrospinning
  • Nerve guide conduit (NGC)
  • Nerve regeneration
  • Permeation
  • PLLA
  • Poly(l-lactic acid)
  • Porous microtube array membrane (p-MTAM)

ASJC Scopus subject areas

  • Polymers and Plastics
  • Physics and Astronomy(all)
  • Organic Chemistry

Cite this

Permeation of biological compounds through porous poly(l-lactic acid) (PLLA) microtube array membranes (MTAMs). / Hung, Wei Chiang; Lin, Lin Hong; Tsen, Wen Chin; Shie, Han Shian; Chiu, Hsien Lung; Yang, Thomas C K; Chen, Chien Chung.

In: European Polymer Journal, Vol. 67, 01.06.2015, p. 166-173.

Research output: Contribution to journalArticle

Hung, Wei Chiang ; Lin, Lin Hong ; Tsen, Wen Chin ; Shie, Han Shian ; Chiu, Hsien Lung ; Yang, Thomas C K ; Chen, Chien Chung. / Permeation of biological compounds through porous poly(l-lactic acid) (PLLA) microtube array membranes (MTAMs). In: European Polymer Journal. 2015 ; Vol. 67. pp. 166-173.
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AU - Hung, Wei Chiang

AU - Lin, Lin Hong

AU - Tsen, Wen Chin

AU - Shie, Han Shian

AU - Chiu, Hsien Lung

AU - Yang, Thomas C K

AU - Chen, Chien Chung

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KW - Nerve guide conduit (NGC)

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KW - Permeation

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KW - Poly(l-lactic acid)

KW - Porous microtube array membrane (p-MTAM)

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