Peritoneal cellular immunity and endometriosis

Hong Nerng Ho, W. U. Ming-Yih, Y. U.Shih Yang

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

PROBLEM: An immunologic basis has long been considered to be very important in the pathogenesis of endometriosis. Interactions of the peritoneal cells, which comprise macrophages, B cells, T cells, natural killer (NK) cells, and retrograde endometrial cells, are critical, but remain controversial, for exploring the pathogenesis of endometriosis. METHOD OF STUDY: Accumulated data from the literature were reviewed, and our data were analyzed. RESULTS: The data show that peritoneal macrophages are activated by the recurrent reflux of menstrual shedding. Humoral and local endometrial autoantibodies are detected in patients with endometriosis, but B cells are not quantitatively increased. There is decreased NK cell activity in the peritoneal cavity and peripheral blood, and this decreased activity may be related to the failure to clear out the ectopic endometrial tissue. Peritoneal T cells are predominant by Th1 inflammatory cells, and these cells are impaired because of a decrease in activation (especially HLA-DR+CD4+CD3+ population) and in the production of interleukin-2. Inflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor-α are elevated in the peritoneal fluid of women with endometriosis. CONCLUSIONS: The peritoneal NK and T lymphocytes are suppressed in women with endometriosis, but whether these immunologic deviations are the cause or the result of endometriosis is still unclear. Further studies are required to determine what role immunologic factors play in the pathophysiology of endometriosis.

Original languageEnglish
Pages (from-to)400-412
Number of pages13
JournalAmerican Journal of Reproductive Immunology
Volume38
Issue number6
DOIs
Publication statusPublished - Jan 1 1997
Externally publishedYes

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Endometriosis
Cellular Immunity
Natural Killer Cells
Macrophages
Cytokines
T-Lymphocytes
B-Lymphocytes
Choristoma
Th1 Cells
Ascitic Fluid
Peritoneal Cavity
Immunologic Factors
Peritoneal Macrophages
HLA-DR Antigens
Interleukin-1
Cell Communication
Autoantibodies
Interleukin-2
Interleukin-6
Tumor Necrosis Factor-alpha

Keywords

  • Cytokine
  • Endometriosis
  • Macrophage
  • NK cells
  • T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Peritoneal cellular immunity and endometriosis. / Ho, Hong Nerng; Ming-Yih, W. U.; Yang, Y. U.Shih.

In: American Journal of Reproductive Immunology, Vol. 38, No. 6, 01.01.1997, p. 400-412.

Research output: Contribution to journalArticle

Ho, Hong Nerng ; Ming-Yih, W. U. ; Yang, Y. U.Shih. / Peritoneal cellular immunity and endometriosis. In: American Journal of Reproductive Immunology. 1997 ; Vol. 38, No. 6. pp. 400-412.
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