Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome

Yi Ju Tsai, Kannan Ramar, Yao Jen Liang, Po Han Chiu, Nelson Powell, Chao Yun Chi, Tzu Chen Lung, Wesley Wen-Yang Lin, Po Jung Tseng, Ming Ying Wu, Kuan Chiao Chien, Edward M. Weaver, Fei Peng Lee, Chia Mo Lin, Kuang Chao Chen, Rayleigh Ping Ying Chiang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that leads to significant morbidity and mortality without adequate treatment. Though much emphasis on the pathogenesis of OSAS has been placed on a narrow upper airway space and associated muscular factors, possible neuropathy of the upper airway has not been fully elucidated. Increasing peer reviewed evidence suggests involvement of neurologic lesions of the upper airway in OSAS patients.In this article, we review the etiology and pathophysiology of OSAS, the evidence and possible mechanisms leading to upper airway neuropathy, and the relationship between upper airway neuropathy and OSAS. Further studies should focus on the long term effects of the upper airway neuropathy as related to the duration and severity of snoring and or apnea, and also on the potential methods of prevention and management of the neuropathy in sleep disordered breathing.

Original languageEnglish
Pages (from-to)161-168
Number of pages8
JournalSleep Medicine Reviews
Volume17
Issue number2
DOIs
Publication statusPublished - Apr 2013

Fingerprint

Obstructive Sleep Apnea
Snoring
Sleep Apnea Syndromes
Apnea
Nervous System
Neuropathology
Morbidity
Mortality

Keywords

  • Hypoxia
  • Inflammation
  • Neuropathology
  • Obstructive sleep apnea syndrome
  • Upper airway surgery
  • Vibration trauma

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)
  • Pulmonary and Respiratory Medicine
  • Neurology

Cite this

Tsai, Y. J., Ramar, K., Liang, Y. J., Chiu, P. H., Powell, N., Chi, C. Y., ... Chiang, R. P. Y. (2013). Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome. Sleep Medicine Reviews, 17(2), 161-168. https://doi.org/10.1016/j.smrv.2012.05.005

Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome. / Tsai, Yi Ju; Ramar, Kannan; Liang, Yao Jen; Chiu, Po Han; Powell, Nelson; Chi, Chao Yun; Lung, Tzu Chen; Wen-Yang Lin, Wesley; Tseng, Po Jung; Wu, Ming Ying; Chien, Kuan Chiao; Weaver, Edward M.; Lee, Fei Peng; Lin, Chia Mo; Chen, Kuang Chao; Chiang, Rayleigh Ping Ying.

In: Sleep Medicine Reviews, Vol. 17, No. 2, 04.2013, p. 161-168.

Research output: Contribution to journalArticle

Tsai, YJ, Ramar, K, Liang, YJ, Chiu, PH, Powell, N, Chi, CY, Lung, TC, Wen-Yang Lin, W, Tseng, PJ, Wu, MY, Chien, KC, Weaver, EM, Lee, FP, Lin, CM, Chen, KC & Chiang, RPY 2013, 'Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome', Sleep Medicine Reviews, vol. 17, no. 2, pp. 161-168. https://doi.org/10.1016/j.smrv.2012.05.005
Tsai, Yi Ju ; Ramar, Kannan ; Liang, Yao Jen ; Chiu, Po Han ; Powell, Nelson ; Chi, Chao Yun ; Lung, Tzu Chen ; Wen-Yang Lin, Wesley ; Tseng, Po Jung ; Wu, Ming Ying ; Chien, Kuan Chiao ; Weaver, Edward M. ; Lee, Fei Peng ; Lin, Chia Mo ; Chen, Kuang Chao ; Chiang, Rayleigh Ping Ying. / Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome. In: Sleep Medicine Reviews. 2013 ; Vol. 17, No. 2. pp. 161-168.
@article{3fd56a9af64b425980b93cd5ab64ac78,
title = "Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome",
abstract = "Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that leads to significant morbidity and mortality without adequate treatment. Though much emphasis on the pathogenesis of OSAS has been placed on a narrow upper airway space and associated muscular factors, possible neuropathy of the upper airway has not been fully elucidated. Increasing peer reviewed evidence suggests involvement of neurologic lesions of the upper airway in OSAS patients.In this article, we review the etiology and pathophysiology of OSAS, the evidence and possible mechanisms leading to upper airway neuropathy, and the relationship between upper airway neuropathy and OSAS. Further studies should focus on the long term effects of the upper airway neuropathy as related to the duration and severity of snoring and or apnea, and also on the potential methods of prevention and management of the neuropathy in sleep disordered breathing.",
keywords = "Hypoxia, Inflammation, Neuropathology, Obstructive sleep apnea syndrome, Upper airway surgery, Vibration trauma",
author = "Tsai, {Yi Ju} and Kannan Ramar and Liang, {Yao Jen} and Chiu, {Po Han} and Nelson Powell and Chi, {Chao Yun} and Lung, {Tzu Chen} and {Wen-Yang Lin}, Wesley and Tseng, {Po Jung} and Wu, {Ming Ying} and Chien, {Kuan Chiao} and Weaver, {Edward M.} and Lee, {Fei Peng} and Lin, {Chia Mo} and Chen, {Kuang Chao} and Chiang, {Rayleigh Ping Ying}",
year = "2013",
month = "4",
doi = "10.1016/j.smrv.2012.05.005",
language = "English",
volume = "17",
pages = "161--168",
journal = "Sleep Medicine Reviews",
issn = "1087-0792",
publisher = "W.B. Saunders Ltd",
number = "2",

}

TY - JOUR

T1 - Peripheral neuropathology of the upper airway in obstructive sleep apnea syndrome

AU - Tsai, Yi Ju

AU - Ramar, Kannan

AU - Liang, Yao Jen

AU - Chiu, Po Han

AU - Powell, Nelson

AU - Chi, Chao Yun

AU - Lung, Tzu Chen

AU - Wen-Yang Lin, Wesley

AU - Tseng, Po Jung

AU - Wu, Ming Ying

AU - Chien, Kuan Chiao

AU - Weaver, Edward M.

AU - Lee, Fei Peng

AU - Lin, Chia Mo

AU - Chen, Kuang Chao

AU - Chiang, Rayleigh Ping Ying

PY - 2013/4

Y1 - 2013/4

N2 - Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that leads to significant morbidity and mortality without adequate treatment. Though much emphasis on the pathogenesis of OSAS has been placed on a narrow upper airway space and associated muscular factors, possible neuropathy of the upper airway has not been fully elucidated. Increasing peer reviewed evidence suggests involvement of neurologic lesions of the upper airway in OSAS patients.In this article, we review the etiology and pathophysiology of OSAS, the evidence and possible mechanisms leading to upper airway neuropathy, and the relationship between upper airway neuropathy and OSAS. Further studies should focus on the long term effects of the upper airway neuropathy as related to the duration and severity of snoring and or apnea, and also on the potential methods of prevention and management of the neuropathy in sleep disordered breathing.

AB - Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that leads to significant morbidity and mortality without adequate treatment. Though much emphasis on the pathogenesis of OSAS has been placed on a narrow upper airway space and associated muscular factors, possible neuropathy of the upper airway has not been fully elucidated. Increasing peer reviewed evidence suggests involvement of neurologic lesions of the upper airway in OSAS patients.In this article, we review the etiology and pathophysiology of OSAS, the evidence and possible mechanisms leading to upper airway neuropathy, and the relationship between upper airway neuropathy and OSAS. Further studies should focus on the long term effects of the upper airway neuropathy as related to the duration and severity of snoring and or apnea, and also on the potential methods of prevention and management of the neuropathy in sleep disordered breathing.

KW - Hypoxia

KW - Inflammation

KW - Neuropathology

KW - Obstructive sleep apnea syndrome

KW - Upper airway surgery

KW - Vibration trauma

UR - http://www.scopus.com/inward/record.url?scp=84873441372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873441372&partnerID=8YFLogxK

U2 - 10.1016/j.smrv.2012.05.005

DO - 10.1016/j.smrv.2012.05.005

M3 - Article

C2 - 22902356

AN - SCOPUS:84873441372

VL - 17

SP - 161

EP - 168

JO - Sleep Medicine Reviews

JF - Sleep Medicine Reviews

SN - 1087-0792

IS - 2

ER -