Perioperative alterations of the thromboelastography in patients receiving one-stage bilateral total knee arthroplasty

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Abstract

Background : Total knee arthroplasty is associated with activation of coagulation and fibrinolytic system in the perioperative period. The coagulation and fibrinolytic activation in one-stage bilateral total knee arthroplasty has not been described before. Thromboelastography is a real-time aid in the monitoring of coagulation and is clinically valuable in the evaluation of whole blood hemostasis. We evaluated the coagulation and fibrinolysis system activation during and after one-stage bilateral total knee arthroplasty by thromboelastography. Methods : Twenty patients, ASA class I-II, undergoing one-stage bilateral total knee arthroplasty were included in this study. All patients received continuous spinal anesthesia with isobaric 0.2% bupivacaine. Arterial blood samples were obtained for thromboelastography in the following sequences: (1) after induction of anesthesia (baseline), (2) 20 min after releasing tourniquet of the first leg, (3) 20 min after releasing tourniquet of the second leg, (4) 2 h postoperatively, (5) 24 h postoperatively. Results : There was a significant shortening of reaction time (R value) after deflation of the first leg tourniquet, and a further decrease of R value after deflation of the second leg tourniquet and two hours postoperatively. The perioperative change of coagulation time was similar to that of R value. The maximum amplitude decreased after releasing tourniquet of the second leg and two hours postoperatively. Conclusion : The activation of coagulation, as monitored by thromboelastography, is predominant in one-stage bilateral total knee arthroplasty after releasing tourniquet of the second leg and returns to baseline 24 h postoperatively.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalActa Anaesthesiologica Sinica
Volume34
Issue number3
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Thrombelastography
Tourniquets
Knee Replacement Arthroplasties
Leg
Perioperative Period
Spinal Anesthesia
Bupivacaine
Fibrinolysis
Hemostasis
Anesthesia

Keywords

  • Blood coagulation tests: Thromboelastography
  • Blood coagulation: Fibrinolysis
  • Orthopedics, arthroplasty: Knee prosthesis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

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title = "Perioperative alterations of the thromboelastography in patients receiving one-stage bilateral total knee arthroplasty",
abstract = "Background : Total knee arthroplasty is associated with activation of coagulation and fibrinolytic system in the perioperative period. The coagulation and fibrinolytic activation in one-stage bilateral total knee arthroplasty has not been described before. Thromboelastography is a real-time aid in the monitoring of coagulation and is clinically valuable in the evaluation of whole blood hemostasis. We evaluated the coagulation and fibrinolysis system activation during and after one-stage bilateral total knee arthroplasty by thromboelastography. Methods : Twenty patients, ASA class I-II, undergoing one-stage bilateral total knee arthroplasty were included in this study. All patients received continuous spinal anesthesia with isobaric 0.2{\%} bupivacaine. Arterial blood samples were obtained for thromboelastography in the following sequences: (1) after induction of anesthesia (baseline), (2) 20 min after releasing tourniquet of the first leg, (3) 20 min after releasing tourniquet of the second leg, (4) 2 h postoperatively, (5) 24 h postoperatively. Results : There was a significant shortening of reaction time (R value) after deflation of the first leg tourniquet, and a further decrease of R value after deflation of the second leg tourniquet and two hours postoperatively. The perioperative change of coagulation time was similar to that of R value. The maximum amplitude decreased after releasing tourniquet of the second leg and two hours postoperatively. Conclusion : The activation of coagulation, as monitored by thromboelastography, is predominant in one-stage bilateral total knee arthroplasty after releasing tourniquet of the second leg and returns to baseline 24 h postoperatively.",
keywords = "Blood coagulation tests: Thromboelastography, Blood coagulation: Fibrinolysis, Orthopedics, arthroplasty: Knee prosthesis",
author = "Ta-Liang Chen",
year = "1996",
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pages = "129--134",
journal = "Asian Journal of Anesthesiology",
issn = "2468-824X",
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TY - JOUR

T1 - Perioperative alterations of the thromboelastography in patients receiving one-stage bilateral total knee arthroplasty

AU - Chen, Ta-Liang

PY - 1996

Y1 - 1996

N2 - Background : Total knee arthroplasty is associated with activation of coagulation and fibrinolytic system in the perioperative period. The coagulation and fibrinolytic activation in one-stage bilateral total knee arthroplasty has not been described before. Thromboelastography is a real-time aid in the monitoring of coagulation and is clinically valuable in the evaluation of whole blood hemostasis. We evaluated the coagulation and fibrinolysis system activation during and after one-stage bilateral total knee arthroplasty by thromboelastography. Methods : Twenty patients, ASA class I-II, undergoing one-stage bilateral total knee arthroplasty were included in this study. All patients received continuous spinal anesthesia with isobaric 0.2% bupivacaine. Arterial blood samples were obtained for thromboelastography in the following sequences: (1) after induction of anesthesia (baseline), (2) 20 min after releasing tourniquet of the first leg, (3) 20 min after releasing tourniquet of the second leg, (4) 2 h postoperatively, (5) 24 h postoperatively. Results : There was a significant shortening of reaction time (R value) after deflation of the first leg tourniquet, and a further decrease of R value after deflation of the second leg tourniquet and two hours postoperatively. The perioperative change of coagulation time was similar to that of R value. The maximum amplitude decreased after releasing tourniquet of the second leg and two hours postoperatively. Conclusion : The activation of coagulation, as monitored by thromboelastography, is predominant in one-stage bilateral total knee arthroplasty after releasing tourniquet of the second leg and returns to baseline 24 h postoperatively.

AB - Background : Total knee arthroplasty is associated with activation of coagulation and fibrinolytic system in the perioperative period. The coagulation and fibrinolytic activation in one-stage bilateral total knee arthroplasty has not been described before. Thromboelastography is a real-time aid in the monitoring of coagulation and is clinically valuable in the evaluation of whole blood hemostasis. We evaluated the coagulation and fibrinolysis system activation during and after one-stage bilateral total knee arthroplasty by thromboelastography. Methods : Twenty patients, ASA class I-II, undergoing one-stage bilateral total knee arthroplasty were included in this study. All patients received continuous spinal anesthesia with isobaric 0.2% bupivacaine. Arterial blood samples were obtained for thromboelastography in the following sequences: (1) after induction of anesthesia (baseline), (2) 20 min after releasing tourniquet of the first leg, (3) 20 min after releasing tourniquet of the second leg, (4) 2 h postoperatively, (5) 24 h postoperatively. Results : There was a significant shortening of reaction time (R value) after deflation of the first leg tourniquet, and a further decrease of R value after deflation of the second leg tourniquet and two hours postoperatively. The perioperative change of coagulation time was similar to that of R value. The maximum amplitude decreased after releasing tourniquet of the second leg and two hours postoperatively. Conclusion : The activation of coagulation, as monitored by thromboelastography, is predominant in one-stage bilateral total knee arthroplasty after releasing tourniquet of the second leg and returns to baseline 24 h postoperatively.

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KW - Blood coagulation: Fibrinolysis

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