Abstract

Objectives: To determine whether periodontitis is a modifiable risk factor for dementia. Design: Prospective cohort study. Setting: National Health Insurance Research Database in Taiwan. Participants: Individuals aged 65 and older with periodontitis (n = 3,028) and an age- and sex-matched control group (n = 3,028). Measurements: Individuals with periodontitis were compared age- and sex-matched controls with for incidence density and hazard ratio (HR) of new-onset dementia. Periodontitis was defined according to International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 523.3–5 diagnosed by dentists. To ensure diagnostic validity, only those who had concurrently received antibiotic therapies, periodontal treatment other than scaling, or scaling more than twice per year performed by certified dentists were included. Dementia was defined according to ICD-9-CM codes 290.0–290.4, 294.1, 331.0–331.2. Results: After adjustment for confounding factors, the risk of developing dementia was calculated to be higher for participants with periodontitis (HR = 1.16, 95% confidence interval = 1.01–1.32, P =.03) than for those without. Conclusion: Periodontitis is associated with greater risk of developing dementia. Periodontal infection is treatable, so it might be a modifiable risk factor for dementia. Clinicians must devote greater attention to this potential association in an effort to develop new preventive and therapeutic strategies for dementia.

Original languageEnglish
Pages (from-to)301-305
Number of pages5
JournalJournal of the American Geriatrics Society
Volume65
Issue number2
DOIs
Publication statusPublished - Feb 1 2017

Fingerprint

Periodontitis
Dementia
Cohort Studies
International Classification of Diseases
Population
Dentists
National Health Programs
Taiwan
Research Design
Therapeutics
Databases
Prospective Studies
Confidence Intervals
Anti-Bacterial Agents
Control Groups
Incidence
Infection
Research

Keywords

  • dementia
  • modifiable risk factor
  • nationwide cohort study
  • periodontitis

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

@article{21706ad866f64aadba55b828f5726156,
title = "Periodontitis as a Modifiable Risk Factor for Dementia: A Nationwide Population-Based Cohort Study",
abstract = "Objectives: To determine whether periodontitis is a modifiable risk factor for dementia. Design: Prospective cohort study. Setting: National Health Insurance Research Database in Taiwan. Participants: Individuals aged 65 and older with periodontitis (n = 3,028) and an age- and sex-matched control group (n = 3,028). Measurements: Individuals with periodontitis were compared age- and sex-matched controls with for incidence density and hazard ratio (HR) of new-onset dementia. Periodontitis was defined according to International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 523.3–5 diagnosed by dentists. To ensure diagnostic validity, only those who had concurrently received antibiotic therapies, periodontal treatment other than scaling, or scaling more than twice per year performed by certified dentists were included. Dementia was defined according to ICD-9-CM codes 290.0–290.4, 294.1, 331.0–331.2. Results: After adjustment for confounding factors, the risk of developing dementia was calculated to be higher for participants with periodontitis (HR = 1.16, 95{\%} confidence interval = 1.01–1.32, P =.03) than for those without. Conclusion: Periodontitis is associated with greater risk of developing dementia. Periodontal infection is treatable, so it might be a modifiable risk factor for dementia. Clinicians must devote greater attention to this potential association in an effort to develop new preventive and therapeutic strategies for dementia.",
keywords = "dementia, modifiable risk factor, nationwide cohort study, periodontitis",
author = "Lee, {Yao Tung} and Lee, {Hsin Chien} and Hu, {Chaur Jongh} and Huang, {Li Kai} and Chao, {Shu Ping} and Lin, {Chia Pei} and Su, {Emily Chia Yu} and Lee, {Yi Chen} and Chen, {Chu Chieh}",
year = "2017",
month = "2",
day = "1",
doi = "10.1111/jgs.14449",
language = "English",
volume = "65",
pages = "301--305",
journal = "Journal of the American Geriatrics Society",
issn = "0002-8614",
publisher = "John Wiley & Sons, Ltd (10.1111)",
number = "2",

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T1 - Periodontitis as a Modifiable Risk Factor for Dementia

T2 - A Nationwide Population-Based Cohort Study

AU - Lee, Yao Tung

AU - Lee, Hsin Chien

AU - Hu, Chaur Jongh

AU - Huang, Li Kai

AU - Chao, Shu Ping

AU - Lin, Chia Pei

AU - Su, Emily Chia Yu

AU - Lee, Yi Chen

AU - Chen, Chu Chieh

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Objectives: To determine whether periodontitis is a modifiable risk factor for dementia. Design: Prospective cohort study. Setting: National Health Insurance Research Database in Taiwan. Participants: Individuals aged 65 and older with periodontitis (n = 3,028) and an age- and sex-matched control group (n = 3,028). Measurements: Individuals with periodontitis were compared age- and sex-matched controls with for incidence density and hazard ratio (HR) of new-onset dementia. Periodontitis was defined according to International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 523.3–5 diagnosed by dentists. To ensure diagnostic validity, only those who had concurrently received antibiotic therapies, periodontal treatment other than scaling, or scaling more than twice per year performed by certified dentists were included. Dementia was defined according to ICD-9-CM codes 290.0–290.4, 294.1, 331.0–331.2. Results: After adjustment for confounding factors, the risk of developing dementia was calculated to be higher for participants with periodontitis (HR = 1.16, 95% confidence interval = 1.01–1.32, P =.03) than for those without. Conclusion: Periodontitis is associated with greater risk of developing dementia. Periodontal infection is treatable, so it might be a modifiable risk factor for dementia. Clinicians must devote greater attention to this potential association in an effort to develop new preventive and therapeutic strategies for dementia.

AB - Objectives: To determine whether periodontitis is a modifiable risk factor for dementia. Design: Prospective cohort study. Setting: National Health Insurance Research Database in Taiwan. Participants: Individuals aged 65 and older with periodontitis (n = 3,028) and an age- and sex-matched control group (n = 3,028). Measurements: Individuals with periodontitis were compared age- and sex-matched controls with for incidence density and hazard ratio (HR) of new-onset dementia. Periodontitis was defined according to International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes 523.3–5 diagnosed by dentists. To ensure diagnostic validity, only those who had concurrently received antibiotic therapies, periodontal treatment other than scaling, or scaling more than twice per year performed by certified dentists were included. Dementia was defined according to ICD-9-CM codes 290.0–290.4, 294.1, 331.0–331.2. Results: After adjustment for confounding factors, the risk of developing dementia was calculated to be higher for participants with periodontitis (HR = 1.16, 95% confidence interval = 1.01–1.32, P =.03) than for those without. Conclusion: Periodontitis is associated with greater risk of developing dementia. Periodontal infection is treatable, so it might be a modifiable risk factor for dementia. Clinicians must devote greater attention to this potential association in an effort to develop new preventive and therapeutic strategies for dementia.

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