Abstract

Background and aim Mild traumatic brain injury (mTBI) causes transient sleep disorders and circadian dysrhythmia. One of the clock genes, PERIOD3 (PER3), regulates the circadian rhythm and contains a genetic polymorphism, namely a variable-number tandem repeat in the coding area with either four or five repeats. PER35 carriers are inclined to have a morning preference and associated with higher risk of bipolar disorder and diabetes. This study investigated the effects of PER3 polymorphism on sleep quality changes after mTBI. Materials and methods From May 2012 to May 2014, a total of 96 mTBI patients completed the baseline (1 week after mTBI) and follow-up (6 weeks after mTBI) assessments, including the Pittsburgh Sleep Quality Index (PSQI) and anxiety and depression questionnaires. Statistics were analyzed using the Mann-Whitney U test, Wilcox signed-rank test or chi-squared test. Results Among the 96 patients, 24 were heterozygous PER35 carriers (PER34/5), and the rest of 72 were PER35 noncarriers (PER34/4). The subscale of PSQI questionnaire results indicated that the PER35 allele was associated with significant sleep duration shortening, but improvement in overall sleep quality. Furthermore, analyzing patients with sleep disturbance at the baseline (PSQI > 5) revealed that only the PER35 noncarriers exhibited a significant improvement in overall PSQI scores. Conclusion PER35 carriers exhibited sleep duration shortening and improved daytime function 6 weeks after mTBI compared with the baseline values. On the other hand, among poor sleepers, PER35 carriers did not embrace a significant improvement of overall PSQI scores as noncarriers. The underlying mechanisms and clinical significances must be investigated further.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
JournalJournal of the Neurological Sciences
Volume358
Issue number1-2
DOIs
Publication statusPublished - Aug 5 2015

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Brain Concussion
Sleep
Minisatellite Repeats
Genetic Polymorphisms
Nonparametric Statistics
Circadian Rhythm
Bipolar Disorder
Anxiety
Alleles

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

PERIOD3 polymorphism is associated with sleep quality recovery after a mild traumatic brain injury. / Hung, Chien-Tai; Wong, Chung Shun; Ma, Hon Ping; Wu, Dean; Huang, Yao Hsien; Wu, Chung-Che; Lin, Chien Min; Su, Yu Kai; Liao, Kuo Hsing; Ou, Ju Chi; Hu, Chaur Jong.

In: Journal of the Neurological Sciences, Vol. 358, No. 1-2, 05.08.2015, p. 385-389.

Research output: Contribution to journalArticle

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title = "PERIOD3 polymorphism is associated with sleep quality recovery after a mild traumatic brain injury",
abstract = "Background and aim Mild traumatic brain injury (mTBI) causes transient sleep disorders and circadian dysrhythmia. One of the clock genes, PERIOD3 (PER3), regulates the circadian rhythm and contains a genetic polymorphism, namely a variable-number tandem repeat in the coding area with either four or five repeats. PER35 carriers are inclined to have a morning preference and associated with higher risk of bipolar disorder and diabetes. This study investigated the effects of PER3 polymorphism on sleep quality changes after mTBI. Materials and methods From May 2012 to May 2014, a total of 96 mTBI patients completed the baseline (1 week after mTBI) and follow-up (6 weeks after mTBI) assessments, including the Pittsburgh Sleep Quality Index (PSQI) and anxiety and depression questionnaires. Statistics were analyzed using the Mann-Whitney U test, Wilcox signed-rank test or chi-squared test. Results Among the 96 patients, 24 were heterozygous PER35 carriers (PER34/5), and the rest of 72 were PER35 noncarriers (PER34/4). The subscale of PSQI questionnaire results indicated that the PER35 allele was associated with significant sleep duration shortening, but improvement in overall sleep quality. Furthermore, analyzing patients with sleep disturbance at the baseline (PSQI > 5) revealed that only the PER35 noncarriers exhibited a significant improvement in overall PSQI scores. Conclusion PER35 carriers exhibited sleep duration shortening and improved daytime function 6 weeks after mTBI compared with the baseline values. On the other hand, among poor sleepers, PER35 carriers did not embrace a significant improvement of overall PSQI scores as noncarriers. The underlying mechanisms and clinical significances must be investigated further.",
author = "Chien-Tai Hung and Wong, {Chung Shun} and Ma, {Hon Ping} and Dean Wu and Huang, {Yao Hsien} and Chung-Che Wu and Lin, {Chien Min} and Su, {Yu Kai} and Liao, {Kuo Hsing} and Ou, {Ju Chi} and Hu, {Chaur Jong}",
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T1 - PERIOD3 polymorphism is associated with sleep quality recovery after a mild traumatic brain injury

AU - Hung, Chien-Tai

AU - Wong, Chung Shun

AU - Ma, Hon Ping

AU - Wu, Dean

AU - Huang, Yao Hsien

AU - Wu, Chung-Che

AU - Lin, Chien Min

AU - Su, Yu Kai

AU - Liao, Kuo Hsing

AU - Ou, Ju Chi

AU - Hu, Chaur Jong

PY - 2015/8/5

Y1 - 2015/8/5

N2 - Background and aim Mild traumatic brain injury (mTBI) causes transient sleep disorders and circadian dysrhythmia. One of the clock genes, PERIOD3 (PER3), regulates the circadian rhythm and contains a genetic polymorphism, namely a variable-number tandem repeat in the coding area with either four or five repeats. PER35 carriers are inclined to have a morning preference and associated with higher risk of bipolar disorder and diabetes. This study investigated the effects of PER3 polymorphism on sleep quality changes after mTBI. Materials and methods From May 2012 to May 2014, a total of 96 mTBI patients completed the baseline (1 week after mTBI) and follow-up (6 weeks after mTBI) assessments, including the Pittsburgh Sleep Quality Index (PSQI) and anxiety and depression questionnaires. Statistics were analyzed using the Mann-Whitney U test, Wilcox signed-rank test or chi-squared test. Results Among the 96 patients, 24 were heterozygous PER35 carriers (PER34/5), and the rest of 72 were PER35 noncarriers (PER34/4). The subscale of PSQI questionnaire results indicated that the PER35 allele was associated with significant sleep duration shortening, but improvement in overall sleep quality. Furthermore, analyzing patients with sleep disturbance at the baseline (PSQI > 5) revealed that only the PER35 noncarriers exhibited a significant improvement in overall PSQI scores. Conclusion PER35 carriers exhibited sleep duration shortening and improved daytime function 6 weeks after mTBI compared with the baseline values. On the other hand, among poor sleepers, PER35 carriers did not embrace a significant improvement of overall PSQI scores as noncarriers. The underlying mechanisms and clinical significances must be investigated further.

AB - Background and aim Mild traumatic brain injury (mTBI) causes transient sleep disorders and circadian dysrhythmia. One of the clock genes, PERIOD3 (PER3), regulates the circadian rhythm and contains a genetic polymorphism, namely a variable-number tandem repeat in the coding area with either four or five repeats. PER35 carriers are inclined to have a morning preference and associated with higher risk of bipolar disorder and diabetes. This study investigated the effects of PER3 polymorphism on sleep quality changes after mTBI. Materials and methods From May 2012 to May 2014, a total of 96 mTBI patients completed the baseline (1 week after mTBI) and follow-up (6 weeks after mTBI) assessments, including the Pittsburgh Sleep Quality Index (PSQI) and anxiety and depression questionnaires. Statistics were analyzed using the Mann-Whitney U test, Wilcox signed-rank test or chi-squared test. Results Among the 96 patients, 24 were heterozygous PER35 carriers (PER34/5), and the rest of 72 were PER35 noncarriers (PER34/4). The subscale of PSQI questionnaire results indicated that the PER35 allele was associated with significant sleep duration shortening, but improvement in overall sleep quality. Furthermore, analyzing patients with sleep disturbance at the baseline (PSQI > 5) revealed that only the PER35 noncarriers exhibited a significant improvement in overall PSQI scores. Conclusion PER35 carriers exhibited sleep duration shortening and improved daytime function 6 weeks after mTBI compared with the baseline values. On the other hand, among poor sleepers, PER35 carriers did not embrace a significant improvement of overall PSQI scores as noncarriers. The underlying mechanisms and clinical significances must be investigated further.

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DO - 10.1016/j.jns.2015.09.376

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JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

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