Pericardial fat is associated with ventricular tachyarrhythmia andmortality in patients with systolic heart failure

Cho Kai Wu, Hao Yuan Tsai, Mao Yuan M. Su, Yi Fan Wu, Juey Jen Hwang, Wen Yih Tseng, Jiunn Lee Lin, Lian Yu Lin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: Pericardial fat (PF) has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity which might be associated with the presence of arrhythmia or even worse outcomes. The aims of this study was to characterize the relationship between PF and the prognosis in patients with systolic heart failure (HF). Methods: This is a retrospective cohort study of a cardiac magnetic resonance imaging (CMRI) database from 2004 to 2011. Fifty patients with systolic HF underwent CMRI examinations were included. We also enrolled twenty patients with HF as the control group. The cine imaging was analyzed to derive total PF volumes, left ventricular volumes and mass and left ventricular ejection fraction by using a previously validated technique. The outcomes, including ventricular tachycardia (VT), ventricular fibrillation (VF) and total mortality were obtained by reviewing medical records. Results: After a median follow-up of 694 days, patients with VT/VF had significant larger indexed PF volumes than those without [36.3 (32.8-43.1) ml/m2 vs. 24.1 (20.2-27.6) ml/m2, p=0.001]. The mortality group also had significant larger indexed PF volumes (PF/body surface area) than those without [31.3 (22.8-38.4) ml/m2 vs. 23.9 (19.8-27.3) ml/m2, p=0.010]. Indexed PF volumes were associated with the development of VT/VF (Hazard ratio, 7.510; 95% C.I, 0.901-62.582, p=0.062) and mortality (Hazard ratio, 3.998; 95% C.I, 1.077-14.845, p=0.038) by Cox's regression analyses. Conclusion: PF is associated with the development of VT/VF and long-term overall mortality in patients with systolic HF.

Original languageEnglish
Pages (from-to)607-614
Number of pages8
JournalAtherosclerosis
Volume241
Issue number2
DOIs
Publication statusPublished - Aug 1 2015
Externally publishedYes

Fingerprint

Systolic Heart Failure
Tachycardia
Fats
Ventricular Fibrillation
Ventricular Tachycardia
Mortality
Magnetic Resonance Imaging
Fat Body
Body Surface Area
Adiposity
Stroke Volume
Medical Records
Cardiac Arrhythmias
Cohort Studies
Heart Failure
Retrospective Studies
Regression Analysis
Databases
Control Groups

Keywords

  • Adipose tissue
  • Magnetic resonance imaging
  • Pericardial fat
  • Ventricular fibrillation
  • Ventricular tachycardia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pericardial fat is associated with ventricular tachyarrhythmia andmortality in patients with systolic heart failure. / Wu, Cho Kai; Tsai, Hao Yuan; Su, Mao Yuan M.; Wu, Yi Fan; Hwang, Juey Jen; Tseng, Wen Yih; Lin, Jiunn Lee; Lin, Lian Yu.

In: Atherosclerosis, Vol. 241, No. 2, 01.08.2015, p. 607-614.

Research output: Contribution to journalArticle

Wu, Cho Kai ; Tsai, Hao Yuan ; Su, Mao Yuan M. ; Wu, Yi Fan ; Hwang, Juey Jen ; Tseng, Wen Yih ; Lin, Jiunn Lee ; Lin, Lian Yu. / Pericardial fat is associated with ventricular tachyarrhythmia andmortality in patients with systolic heart failure. In: Atherosclerosis. 2015 ; Vol. 241, No. 2. pp. 607-614.
@article{7164679e4c504229999ccba627493838,
title = "Pericardial fat is associated with ventricular tachyarrhythmia andmortality in patients with systolic heart failure",
abstract = "Objective: Pericardial fat (PF) has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity which might be associated with the presence of arrhythmia or even worse outcomes. The aims of this study was to characterize the relationship between PF and the prognosis in patients with systolic heart failure (HF). Methods: This is a retrospective cohort study of a cardiac magnetic resonance imaging (CMRI) database from 2004 to 2011. Fifty patients with systolic HF underwent CMRI examinations were included. We also enrolled twenty patients with HF as the control group. The cine imaging was analyzed to derive total PF volumes, left ventricular volumes and mass and left ventricular ejection fraction by using a previously validated technique. The outcomes, including ventricular tachycardia (VT), ventricular fibrillation (VF) and total mortality were obtained by reviewing medical records. Results: After a median follow-up of 694 days, patients with VT/VF had significant larger indexed PF volumes than those without [36.3 (32.8-43.1) ml/m2 vs. 24.1 (20.2-27.6) ml/m2, p=0.001]. The mortality group also had significant larger indexed PF volumes (PF/body surface area) than those without [31.3 (22.8-38.4) ml/m2 vs. 23.9 (19.8-27.3) ml/m2, p=0.010]. Indexed PF volumes were associated with the development of VT/VF (Hazard ratio, 7.510; 95{\%} C.I, 0.901-62.582, p=0.062) and mortality (Hazard ratio, 3.998; 95{\%} C.I, 1.077-14.845, p=0.038) by Cox's regression analyses. Conclusion: PF is associated with the development of VT/VF and long-term overall mortality in patients with systolic HF.",
keywords = "Adipose tissue, Magnetic resonance imaging, Pericardial fat, Ventricular fibrillation, Ventricular tachycardia, Adipose tissue, Magnetic resonance imaging, Pericardial fat, Ventricular fibrillation, Ventricular tachycardia",
author = "Wu, {Cho Kai} and Tsai, {Hao Yuan} and Su, {Mao Yuan M.} and Wu, {Yi Fan} and Hwang, {Juey Jen} and Tseng, {Wen Yih} and Lin, {Jiunn Lee} and Lin, {Lian Yu}",
year = "2015",
month = "8",
day = "1",
doi = "10.1016/j.atherosclerosis.2015.05.025",
language = "English",
volume = "241",
pages = "607--614",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Pericardial fat is associated with ventricular tachyarrhythmia andmortality in patients with systolic heart failure

AU - Wu, Cho Kai

AU - Tsai, Hao Yuan

AU - Su, Mao Yuan M.

AU - Wu, Yi Fan

AU - Hwang, Juey Jen

AU - Tseng, Wen Yih

AU - Lin, Jiunn Lee

AU - Lin, Lian Yu

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Objective: Pericardial fat (PF) has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity which might be associated with the presence of arrhythmia or even worse outcomes. The aims of this study was to characterize the relationship between PF and the prognosis in patients with systolic heart failure (HF). Methods: This is a retrospective cohort study of a cardiac magnetic resonance imaging (CMRI) database from 2004 to 2011. Fifty patients with systolic HF underwent CMRI examinations were included. We also enrolled twenty patients with HF as the control group. The cine imaging was analyzed to derive total PF volumes, left ventricular volumes and mass and left ventricular ejection fraction by using a previously validated technique. The outcomes, including ventricular tachycardia (VT), ventricular fibrillation (VF) and total mortality were obtained by reviewing medical records. Results: After a median follow-up of 694 days, patients with VT/VF had significant larger indexed PF volumes than those without [36.3 (32.8-43.1) ml/m2 vs. 24.1 (20.2-27.6) ml/m2, p=0.001]. The mortality group also had significant larger indexed PF volumes (PF/body surface area) than those without [31.3 (22.8-38.4) ml/m2 vs. 23.9 (19.8-27.3) ml/m2, p=0.010]. Indexed PF volumes were associated with the development of VT/VF (Hazard ratio, 7.510; 95% C.I, 0.901-62.582, p=0.062) and mortality (Hazard ratio, 3.998; 95% C.I, 1.077-14.845, p=0.038) by Cox's regression analyses. Conclusion: PF is associated with the development of VT/VF and long-term overall mortality in patients with systolic HF.

AB - Objective: Pericardial fat (PF) has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity which might be associated with the presence of arrhythmia or even worse outcomes. The aims of this study was to characterize the relationship between PF and the prognosis in patients with systolic heart failure (HF). Methods: This is a retrospective cohort study of a cardiac magnetic resonance imaging (CMRI) database from 2004 to 2011. Fifty patients with systolic HF underwent CMRI examinations were included. We also enrolled twenty patients with HF as the control group. The cine imaging was analyzed to derive total PF volumes, left ventricular volumes and mass and left ventricular ejection fraction by using a previously validated technique. The outcomes, including ventricular tachycardia (VT), ventricular fibrillation (VF) and total mortality were obtained by reviewing medical records. Results: After a median follow-up of 694 days, patients with VT/VF had significant larger indexed PF volumes than those without [36.3 (32.8-43.1) ml/m2 vs. 24.1 (20.2-27.6) ml/m2, p=0.001]. The mortality group also had significant larger indexed PF volumes (PF/body surface area) than those without [31.3 (22.8-38.4) ml/m2 vs. 23.9 (19.8-27.3) ml/m2, p=0.010]. Indexed PF volumes were associated with the development of VT/VF (Hazard ratio, 7.510; 95% C.I, 0.901-62.582, p=0.062) and mortality (Hazard ratio, 3.998; 95% C.I, 1.077-14.845, p=0.038) by Cox's regression analyses. Conclusion: PF is associated with the development of VT/VF and long-term overall mortality in patients with systolic HF.

KW - Adipose tissue

KW - Magnetic resonance imaging

KW - Pericardial fat

KW - Ventricular fibrillation

KW - Ventricular tachycardia

KW - Adipose tissue

KW - Magnetic resonance imaging

KW - Pericardial fat

KW - Ventricular fibrillation

KW - Ventricular tachycardia

UR - http://www.scopus.com/inward/record.url?scp=84935029203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84935029203&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2015.05.025

DO - 10.1016/j.atherosclerosis.2015.05.025

M3 - Article

VL - 241

SP - 607

EP - 614

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -