3 Citations (Scopus)

Abstract

Background: Pericardial fat is correlated with the occurrence of atrial fibrillation or coronary atherosclerosis. However, the role of pericardial fat in ventricular arrhythmia remains unclear. Methods and Results: Patients who had undergone dual-source computed tomography and 24-h Holter ECG were retrospectively enrolled. Quantification of the volume of pericardial fat surrounding the ventricles was analyzed using threshold attenuation of dual-source CT. The volume of pericardial fat was significantly different among those without ventricular premature beats (VPBs) in 24 h (n=28), those with occasional VPBs (n=54) and those with frequent VPBs (n=34) (12.5±6.1 cm3 vs. 14±8.9 cm3 vs. 29.9±17.3 cm3, P<0.001). In addition, the number of VPBs strongly correlated with the volume of total pericardial fat (R=0.501, P<0.001), right ventricular (RV) pericardial fat (R=0.539, P<0.001), and left ventricular pericardial fat (R=0.376, P<0.001). Multivariate logistic regression analysis showed that quartiles of RV localized pericardial fat significantly increased the risk of frequent VPBs (OR=3.2, P=0.047). Moreover, the number of VPBs in 24 h was significantly different among the patients with a fat volume within the 25th percentile, 25–75th percentile and 75th percentile. Conclusions: Pericardial fat (especially RV pericardial fat) was associated with the frequency of VPBs, which suggests the arrhythmogenic potential of ventricular pericardial fat.

Original languageEnglish
Pages (from-to)1726-1733
Number of pages8
JournalCirculation Journal
Volume80
Issue number8
DOIs
Publication statusPublished - 2016

Fingerprint

Cardiac Arrhythmias
Fats
Ventricular Premature Complexes
Atrial Fibrillation
Coronary Artery Disease
Electrocardiography
Logistic Models
Tomography
Regression Analysis

Keywords

  • Dual-source computed tomography
  • Pericardial fat
  • Ventricular arrhythmia

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pericardial fat is associated with the risk of ventricular arrhythmia in asian patients. / Tam, Weng Chio; Lin, Yung Kuo; Chan, Wing Pong; Huang, Jen Hung; Hsieh, Ming Hsiung; Chen, Shih Ann; Chen, Yi Jen.

In: Circulation Journal, Vol. 80, No. 8, 2016, p. 1726-1733.

Research output: Contribution to journalArticle

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title = "Pericardial fat is associated with the risk of ventricular arrhythmia in asian patients",
abstract = "Background: Pericardial fat is correlated with the occurrence of atrial fibrillation or coronary atherosclerosis. However, the role of pericardial fat in ventricular arrhythmia remains unclear. Methods and Results: Patients who had undergone dual-source computed tomography and 24-h Holter ECG were retrospectively enrolled. Quantification of the volume of pericardial fat surrounding the ventricles was analyzed using threshold attenuation of dual-source CT. The volume of pericardial fat was significantly different among those without ventricular premature beats (VPBs) in 24 h (n=28), those with occasional VPBs (n=54) and those with frequent VPBs (n=34) (12.5±6.1 cm3 vs. 14±8.9 cm3 vs. 29.9±17.3 cm3, P<0.001). In addition, the number of VPBs strongly correlated with the volume of total pericardial fat (R=0.501, P<0.001), right ventricular (RV) pericardial fat (R=0.539, P<0.001), and left ventricular pericardial fat (R=0.376, P<0.001). Multivariate logistic regression analysis showed that quartiles of RV localized pericardial fat significantly increased the risk of frequent VPBs (OR=3.2, P=0.047). Moreover, the number of VPBs in 24 h was significantly different among the patients with a fat volume within the 25th percentile, 25–75th percentile and 75th percentile. Conclusions: Pericardial fat (especially RV pericardial fat) was associated with the frequency of VPBs, which suggests the arrhythmogenic potential of ventricular pericardial fat.",
keywords = "Dual-source computed tomography, Pericardial fat, Ventricular arrhythmia",
author = "Tam, {Weng Chio} and Lin, {Yung Kuo} and Chan, {Wing Pong} and Huang, {Jen Hung} and Hsieh, {Ming Hsiung} and Chen, {Shih Ann} and Chen, {Yi Jen}",
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T1 - Pericardial fat is associated with the risk of ventricular arrhythmia in asian patients

AU - Tam, Weng Chio

AU - Lin, Yung Kuo

AU - Chan, Wing Pong

AU - Huang, Jen Hung

AU - Hsieh, Ming Hsiung

AU - Chen, Shih Ann

AU - Chen, Yi Jen

PY - 2016

Y1 - 2016

N2 - Background: Pericardial fat is correlated with the occurrence of atrial fibrillation or coronary atherosclerosis. However, the role of pericardial fat in ventricular arrhythmia remains unclear. Methods and Results: Patients who had undergone dual-source computed tomography and 24-h Holter ECG were retrospectively enrolled. Quantification of the volume of pericardial fat surrounding the ventricles was analyzed using threshold attenuation of dual-source CT. The volume of pericardial fat was significantly different among those without ventricular premature beats (VPBs) in 24 h (n=28), those with occasional VPBs (n=54) and those with frequent VPBs (n=34) (12.5±6.1 cm3 vs. 14±8.9 cm3 vs. 29.9±17.3 cm3, P<0.001). In addition, the number of VPBs strongly correlated with the volume of total pericardial fat (R=0.501, P<0.001), right ventricular (RV) pericardial fat (R=0.539, P<0.001), and left ventricular pericardial fat (R=0.376, P<0.001). Multivariate logistic regression analysis showed that quartiles of RV localized pericardial fat significantly increased the risk of frequent VPBs (OR=3.2, P=0.047). Moreover, the number of VPBs in 24 h was significantly different among the patients with a fat volume within the 25th percentile, 25–75th percentile and 75th percentile. Conclusions: Pericardial fat (especially RV pericardial fat) was associated with the frequency of VPBs, which suggests the arrhythmogenic potential of ventricular pericardial fat.

AB - Background: Pericardial fat is correlated with the occurrence of atrial fibrillation or coronary atherosclerosis. However, the role of pericardial fat in ventricular arrhythmia remains unclear. Methods and Results: Patients who had undergone dual-source computed tomography and 24-h Holter ECG were retrospectively enrolled. Quantification of the volume of pericardial fat surrounding the ventricles was analyzed using threshold attenuation of dual-source CT. The volume of pericardial fat was significantly different among those without ventricular premature beats (VPBs) in 24 h (n=28), those with occasional VPBs (n=54) and those with frequent VPBs (n=34) (12.5±6.1 cm3 vs. 14±8.9 cm3 vs. 29.9±17.3 cm3, P<0.001). In addition, the number of VPBs strongly correlated with the volume of total pericardial fat (R=0.501, P<0.001), right ventricular (RV) pericardial fat (R=0.539, P<0.001), and left ventricular pericardial fat (R=0.376, P<0.001). Multivariate logistic regression analysis showed that quartiles of RV localized pericardial fat significantly increased the risk of frequent VPBs (OR=3.2, P=0.047). Moreover, the number of VPBs in 24 h was significantly different among the patients with a fat volume within the 25th percentile, 25–75th percentile and 75th percentile. Conclusions: Pericardial fat (especially RV pericardial fat) was associated with the frequency of VPBs, which suggests the arrhythmogenic potential of ventricular pericardial fat.

KW - Dual-source computed tomography

KW - Pericardial fat

KW - Ventricular arrhythmia

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U2 - 10.1253/circj.CJ-16-0047

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JO - Circulation Journal

JF - Circulation Journal

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