大豆煮汁的胃蛋白酶水解物中具有抑制血管收縮素轉換酵素之勝肽

Translated title of the contribution: Peptides with angiotensin I converting enzyme inhibitory activity in pepsin-digests of soybean broth

J. R. Chen, S. C. Yang, Y. L. Liu, K. Suetsuna, M. J. Shieh

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Eight inhibitory peptides of angiotensin I converting enzyme (ACE) were isolated from the hydrolysate of soybean broth. The amino acid sequences of these peptides identified by Edman procedure were: Val-Thr-Val-Pro-Gln, Val- Val-Phe-Asp, Gly-Glu-Leu-Phe-Glu, Ile-Thr-Pro-Leu, Gln-Val-Val-Phe, Val-Gln- Val-Val-Phe, Ile-Val-Phe-Asp-Ala and Gly-Asp-Ala-Pro-Asn. The IC50 value of these peptides for ACE from bovine lung were: 6.3, 3.9, 2.3, 5.2, 4.6, 3.4, 4.1 and 2.8 x 10-5 M, respectively. These peptides contained hydrophobic and aromatic amino acids. This characteristic, was considered to be highly related to their inhibitory effect on ACE activity.

Translated title of the contributionPeptides with angiotensin I converting enzyme inhibitory activity in pepsin-digests of soybean broth
Original languageChinese (Traditional)
Pages (from-to)435-444
Number of pages10
JournalNutritional Sciences Journal
Volume22
Issue number4
Publication statusPublished - 1997

Keywords

  • Angiotensin I converting enzyme
  • Peptide
  • Soybean
  • Soybean protein

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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