PEGylated silica nanoparticles encapsulating multiple magnetite nanocrystals for high-performance microscopic magnetic resonance angiography

Si Han Wu, Chien Yuan Lin, Yann Hung, Wei Chen, Chen Chang, Chung Yuan Mou

Research output: Contribution to journalArticle

22 Citations (Scopus)


A novel magnetic resonance (MR) angiographic method, 3DΔR2-mMRA (three dimensional and ΔR2 based microscopy magnetic resonance angiography), is developed as a clinical diagnosis for depicting the function and structure of cerebral small vessels. However, the visibility of microvasculatures and the precision of cerebral blood volume calculation greatly rely on the transverse relaxivity and intravascular half-life of contrast agent, respectively. In this work, we report a blood pool contrast agent named H-Fe 3O 4@SiO 2-PEG where multiple Fe 3O 4 nanocrystals are encapsulated in a thin silica shell to enhance the T 2-relaxivity (r 2 = 342.8 mM -1 s -1) and poly(ethylene glycol) (PEG) is employed to reduce opsonization and prolong circulation time of nanoparticles. Utilization of the newly developed H-Fe 3O 4@SiO 2-PEG with a novel MR angiographic methodology, a high-resolution MR image of rat cerebral microvasculatures is successfully obtained.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume99 B
Issue number1
Publication statusPublished - Oct 2011
Externally publishedYes



  • contrast agents
  • Fe O
  • MRI
  • polyethylene glycol
  • silica

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

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