Pedophilia is Linked to Reduced Activation in Hypothalamus and Lateral Prefrontal Cortex During Visual Erotic Stimulation

Martin Walter, Joachim Witzel, Christine Wiebking, Udo Gubka, Michael Rotte, Kolja Schiltz, Felix Bermpohl, Claus Tempelmann, Bernhard Bogerts, Hans Jochen Heinze, Georg Northoff

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Background: Although pedophilia is of high public concern, little is known about underlying neural mechanisms. Although pedophilic patients are sexually attracted to prepubescent children, they show no sexual interest toward adults. This study aimed to investigate the neural correlates of deficits of sexual and emotional arousal in pedophiles. Methods: Thirteen pedophilic patients and 14 healthy control subjects were tested for differential neural activity during visual stimulation with emotional and erotic pictures with functional magnetic resonance imaging. Results: Regions showing differential activations during the erotic condition comprised the hypothalamus, the periaqueductal gray, and dorsolateral prefrontal cortex, the latter correlating with a clinical measure. Alterations of emotional processing concerned the amygdala-hippocampus and dorsomedial prefrontal cortex. Conclusions: Hypothesized regions relevant for processing of erotic stimuli in healthy individuals showed reduced activations during visual erotic stimulation in pedophilic patients. This suggests an impaired recruitment of key structures that might contribute to an altered sexual interest of these patients toward adults.

Original languageEnglish
Pages (from-to)698-701
Number of pages4
JournalBiological Psychiatry
Volume62
Issue number6
DOIs
Publication statusPublished - Sep 15 2007

Keywords

  • Dorsolateral prefrontal cortex
  • fMRI
  • hypothalamus
  • neural mechanism
  • pedophilia
  • periaqueductal gray

ASJC Scopus subject areas

  • Biological Psychiatry

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    Walter, M., Witzel, J., Wiebking, C., Gubka, U., Rotte, M., Schiltz, K., Bermpohl, F., Tempelmann, C., Bogerts, B., Heinze, H. J., & Northoff, G. (2007). Pedophilia is Linked to Reduced Activation in Hypothalamus and Lateral Prefrontal Cortex During Visual Erotic Stimulation. Biological Psychiatry, 62(6), 698-701. https://doi.org/10.1016/j.biopsych.2006.10.018