Pediatric intracranial germinoma treated with chemotherapy alone

Kuo Tarng Farng, Kai Ping Chang, Tai-Tong Wong, Wan Yuo Guo, Donald M. Ho, Wen Long Hu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background. Pediatric intracranial germinoma treated with radiotherapy is considered a standard treatment, but may cause significant delayed damage to the central nervous system. Chemotherapy has been shown to be effective for the treatment of an intracranial germinoma. In the past 10 years, we treated 11 cases of primary intracranial germinoma with chemotherapy alone. The purpose of this retrospective study is to review the clinical outcome of these patients. Methods. Eleven children with newly diagnosed, previously untreated primary intracranial germinomas were treated with six courses of chemotherapy (vinblastine bleomycin, cisplatin and etoposide, VBPE). The response to chemotherapy, relapses and outcomes are reviewed and evaluated. Results. All 11 assessable children achieved a complete response and are alive, with a median follow-up of 61 months. Five patients with tumors located in the midline position of the brain, including pineal, sellar, suprasellar and hypothalamic areas, had no relapse. Six patients had relapses, and all of them achieved a second complete remission after salvage focal radiotherapy. The time of onset of relapse was from nine to 24 months after chemotherapy, with an average of 16.8 months. Conclusions. VBPE chemotherapy was effective for treating newly diagnosed intracranial germinomas. Although a high rate of relapse (6/11) was observed, all of these patients survived with first or second complete remissions. It was beneficial for five children that focal radiation was eliminated and delayed post- irradiation neurologic sequelae were avoided.

Original languageEnglish
Pages (from-to)859-866
Number of pages8
JournalChinese Medical Journal (Taipei)
Volume62
Issue number12
Publication statusPublished - Dec 1 1999
Externally publishedYes

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Germinoma
Pediatrics
Drug Therapy
Recurrence
Vinblastine
Bleomycin
Etoposide
Cisplatin
Radiotherapy
Nervous System
Central Nervous System
Retrospective Studies
Radiation
Brain
Therapeutics

Keywords

  • Chemotherapy
  • Germ cell tumor
  • Intracranial
  • Intracranial germinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Farng, K. T., Chang, K. P., Wong, T-T., Guo, W. Y., Ho, D. M., & Hu, W. L. (1999). Pediatric intracranial germinoma treated with chemotherapy alone. Chinese Medical Journal (Taipei), 62(12), 859-866.

Pediatric intracranial germinoma treated with chemotherapy alone. / Farng, Kuo Tarng; Chang, Kai Ping; Wong, Tai-Tong; Guo, Wan Yuo; Ho, Donald M.; Hu, Wen Long.

In: Chinese Medical Journal (Taipei), Vol. 62, No. 12, 01.12.1999, p. 859-866.

Research output: Contribution to journalArticle

Farng, KT, Chang, KP, Wong, T-T, Guo, WY, Ho, DM & Hu, WL 1999, 'Pediatric intracranial germinoma treated with chemotherapy alone', Chinese Medical Journal (Taipei), vol. 62, no. 12, pp. 859-866.
Farng KT, Chang KP, Wong T-T, Guo WY, Ho DM, Hu WL. Pediatric intracranial germinoma treated with chemotherapy alone. Chinese Medical Journal (Taipei). 1999 Dec 1;62(12):859-866.
Farng, Kuo Tarng ; Chang, Kai Ping ; Wong, Tai-Tong ; Guo, Wan Yuo ; Ho, Donald M. ; Hu, Wen Long. / Pediatric intracranial germinoma treated with chemotherapy alone. In: Chinese Medical Journal (Taipei). 1999 ; Vol. 62, No. 12. pp. 859-866.
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abstract = "Background. Pediatric intracranial germinoma treated with radiotherapy is considered a standard treatment, but may cause significant delayed damage to the central nervous system. Chemotherapy has been shown to be effective for the treatment of an intracranial germinoma. In the past 10 years, we treated 11 cases of primary intracranial germinoma with chemotherapy alone. The purpose of this retrospective study is to review the clinical outcome of these patients. Methods. Eleven children with newly diagnosed, previously untreated primary intracranial germinomas were treated with six courses of chemotherapy (vinblastine bleomycin, cisplatin and etoposide, VBPE). The response to chemotherapy, relapses and outcomes are reviewed and evaluated. Results. All 11 assessable children achieved a complete response and are alive, with a median follow-up of 61 months. Five patients with tumors located in the midline position of the brain, including pineal, sellar, suprasellar and hypothalamic areas, had no relapse. Six patients had relapses, and all of them achieved a second complete remission after salvage focal radiotherapy. The time of onset of relapse was from nine to 24 months after chemotherapy, with an average of 16.8 months. Conclusions. VBPE chemotherapy was effective for treating newly diagnosed intracranial germinomas. Although a high rate of relapse (6/11) was observed, all of these patients survived with first or second complete remissions. It was beneficial for five children that focal radiation was eliminated and delayed post- irradiation neurologic sequelae were avoided.",
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AU - Hu, Wen Long

PY - 1999/12/1

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