PDD-5S: A useful screening tool for Parkinson's disease dementia

Wei Ju Lee, Shey Lin Wu, Jie Yuan Li, Chih-Chung Chen, Juei Jueng Lin, Giia Sheun Peng, Tsu Kung Lin, Shuu Jiun Wang, Rou Shayn Chen, Yuan Han Yang, Chon Haw Tsai, Jung Lung Hsu, Yi Chu Liao, Shih Pin Chen, Jong Ling Fuh

Research output: Contribution to journalArticle

Abstract

Introduction Parkinson's disease dementia (PDD) contributes to poor quality of life and increases the mortality risk. Early detection and diagnosis of PDD are essential for clinical care. Methods We recruited patients with idiopathic Parkinson's disease (PD), who underwent clinical assessments and neuropsychological tests, at 12 teaching hospitals in Taiwan. Probable PDD was diagnosed according to the Movement Disorder Society Task Force clinical criteria. Using binary logistic regression, we selected significant items from an original 30-item informant questionnaire. We utilized these items, along with a simple cognitive test, to discriminate between PDD and nondemented PD (PD-ND). Results Among the 265 PD patients (156 men, 109 women, mean age 71.9 ± 9.1 years), 102 and 163 patients were diagnosed with probable PDD and PD-ND, respectively. The mean education of participants was 8.8 ± 5.3 years, and the mean disease duration was 5.5 ± 5.4 years. When the patients fulfilled either of the following criteria: (1) a score ≥ 3 for the five endorsed screening questions, (2) a score of 1–2 for the five above screening questions combined with a score ≤ 10 items for category verbal fluency, the sensitivity and specificity of the PDD screening tool were 80.4% and 80.4%, respectively. The area under the receiver operating characteristic curve (AUC) was 0.804. We tested this screening tool in another 137 unrelated PD patients and the sensitivity, specificity, and AUC were 77.4%, 96.4%, and 0.869, respectively. Conclusion The “PDD-5S” is a brief and useful screening tool for PDD.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalParkinsonism and Related Disorders
Volume25
DOIs
Publication statusPublished - Apr 1 2016

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Parkinson Disease
Dementia
Area Under Curve
Sensitivity and Specificity
Neuropsychological Tests
Advisory Committees
Taiwan
ROC Curve
Teaching Hospitals
Early Diagnosis
Logistic Models
Quality of Life
Education
Mortality

Keywords

  • Parkinson's disease with dementia
  • Screening

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

PDD-5S : A useful screening tool for Parkinson's disease dementia. / Lee, Wei Ju; Wu, Shey Lin; Li, Jie Yuan; Chen, Chih-Chung; Lin, Juei Jueng; Peng, Giia Sheun; Lin, Tsu Kung; Wang, Shuu Jiun; Chen, Rou Shayn; Yang, Yuan Han; Tsai, Chon Haw; Hsu, Jung Lung; Liao, Yi Chu; Chen, Shih Pin; Fuh, Jong Ling.

In: Parkinsonism and Related Disorders, Vol. 25, 01.04.2016, p. 85-90.

Research output: Contribution to journalArticle

Lee, WJ, Wu, SL, Li, JY, Chen, C-C, Lin, JJ, Peng, GS, Lin, TK, Wang, SJ, Chen, RS, Yang, YH, Tsai, CH, Hsu, JL, Liao, YC, Chen, SP & Fuh, JL 2016, 'PDD-5S: A useful screening tool for Parkinson's disease dementia', Parkinsonism and Related Disorders, vol. 25, pp. 85-90. https://doi.org/10.1016/j.parkreldis.2016.02.001
Lee, Wei Ju ; Wu, Shey Lin ; Li, Jie Yuan ; Chen, Chih-Chung ; Lin, Juei Jueng ; Peng, Giia Sheun ; Lin, Tsu Kung ; Wang, Shuu Jiun ; Chen, Rou Shayn ; Yang, Yuan Han ; Tsai, Chon Haw ; Hsu, Jung Lung ; Liao, Yi Chu ; Chen, Shih Pin ; Fuh, Jong Ling. / PDD-5S : A useful screening tool for Parkinson's disease dementia. In: Parkinsonism and Related Disorders. 2016 ; Vol. 25. pp. 85-90.
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abstract = "Introduction Parkinson's disease dementia (PDD) contributes to poor quality of life and increases the mortality risk. Early detection and diagnosis of PDD are essential for clinical care. Methods We recruited patients with idiopathic Parkinson's disease (PD), who underwent clinical assessments and neuropsychological tests, at 12 teaching hospitals in Taiwan. Probable PDD was diagnosed according to the Movement Disorder Society Task Force clinical criteria. Using binary logistic regression, we selected significant items from an original 30-item informant questionnaire. We utilized these items, along with a simple cognitive test, to discriminate between PDD and nondemented PD (PD-ND). Results Among the 265 PD patients (156 men, 109 women, mean age 71.9 ± 9.1 years), 102 and 163 patients were diagnosed with probable PDD and PD-ND, respectively. The mean education of participants was 8.8 ± 5.3 years, and the mean disease duration was 5.5 ± 5.4 years. When the patients fulfilled either of the following criteria: (1) a score ≥ 3 for the five endorsed screening questions, (2) a score of 1–2 for the five above screening questions combined with a score ≤ 10 items for category verbal fluency, the sensitivity and specificity of the PDD screening tool were 80.4{\%} and 80.4{\%}, respectively. The area under the receiver operating characteristic curve (AUC) was 0.804. We tested this screening tool in another 137 unrelated PD patients and the sensitivity, specificity, and AUC were 77.4{\%}, 96.4{\%}, and 0.869, respectively. Conclusion The “PDD-5S” is a brief and useful screening tool for PDD.",
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AU - Wu, Shey Lin

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AU - Chen, Chih-Chung

AU - Lin, Juei Jueng

AU - Peng, Giia Sheun

AU - Lin, Tsu Kung

AU - Wang, Shuu Jiun

AU - Chen, Rou Shayn

AU - Yang, Yuan Han

AU - Tsai, Chon Haw

AU - Hsu, Jung Lung

AU - Liao, Yi Chu

AU - Chen, Shih Pin

AU - Fuh, Jong Ling

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N2 - Introduction Parkinson's disease dementia (PDD) contributes to poor quality of life and increases the mortality risk. Early detection and diagnosis of PDD are essential for clinical care. Methods We recruited patients with idiopathic Parkinson's disease (PD), who underwent clinical assessments and neuropsychological tests, at 12 teaching hospitals in Taiwan. Probable PDD was diagnosed according to the Movement Disorder Society Task Force clinical criteria. Using binary logistic regression, we selected significant items from an original 30-item informant questionnaire. We utilized these items, along with a simple cognitive test, to discriminate between PDD and nondemented PD (PD-ND). Results Among the 265 PD patients (156 men, 109 women, mean age 71.9 ± 9.1 years), 102 and 163 patients were diagnosed with probable PDD and PD-ND, respectively. The mean education of participants was 8.8 ± 5.3 years, and the mean disease duration was 5.5 ± 5.4 years. When the patients fulfilled either of the following criteria: (1) a score ≥ 3 for the five endorsed screening questions, (2) a score of 1–2 for the five above screening questions combined with a score ≤ 10 items for category verbal fluency, the sensitivity and specificity of the PDD screening tool were 80.4% and 80.4%, respectively. The area under the receiver operating characteristic curve (AUC) was 0.804. We tested this screening tool in another 137 unrelated PD patients and the sensitivity, specificity, and AUC were 77.4%, 96.4%, and 0.869, respectively. Conclusion The “PDD-5S” is a brief and useful screening tool for PDD.

AB - Introduction Parkinson's disease dementia (PDD) contributes to poor quality of life and increases the mortality risk. Early detection and diagnosis of PDD are essential for clinical care. Methods We recruited patients with idiopathic Parkinson's disease (PD), who underwent clinical assessments and neuropsychological tests, at 12 teaching hospitals in Taiwan. Probable PDD was diagnosed according to the Movement Disorder Society Task Force clinical criteria. Using binary logistic regression, we selected significant items from an original 30-item informant questionnaire. We utilized these items, along with a simple cognitive test, to discriminate between PDD and nondemented PD (PD-ND). Results Among the 265 PD patients (156 men, 109 women, mean age 71.9 ± 9.1 years), 102 and 163 patients were diagnosed with probable PDD and PD-ND, respectively. The mean education of participants was 8.8 ± 5.3 years, and the mean disease duration was 5.5 ± 5.4 years. When the patients fulfilled either of the following criteria: (1) a score ≥ 3 for the five endorsed screening questions, (2) a score of 1–2 for the five above screening questions combined with a score ≤ 10 items for category verbal fluency, the sensitivity and specificity of the PDD screening tool were 80.4% and 80.4%, respectively. The area under the receiver operating characteristic curve (AUC) was 0.804. We tested this screening tool in another 137 unrelated PD patients and the sensitivity, specificity, and AUC were 77.4%, 96.4%, and 0.869, respectively. Conclusion The “PDD-5S” is a brief and useful screening tool for PDD.

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