Paw pressure test in the rabbit: A new animal model for the study of pain

Oliver Yoa Pu Hu

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Background: In order to develope an animal model which is suitable for the pharmacokinetic (PK) and pharmacodynamic (PD) studies of analgesics in the field of pain assessment, we examined a new animal model, the paw pressure test (PPT), in rabbits for the study of pain. Methods : The sensitivity of the model was tested with a broad range of drugs, including mu-opioid agonist (morphine), kappa-opioid agonist (nalbuphine), three non-opioid analgesics (acetaminophen, ketoprofen and indomethacin) and two non-analgesics (droperidol and diazepam). Furthermore, PK and PD studies of nalbuphine (chosen as an example of analgesics) were performed. Results : The authors found that the PPT in rabbits recognized the antinociceptive activities of both opioid and non-opioid analgesics with no positive response to non-analgesics. AD50s determined by the PPT in rabbits for morphine and nalbuphine were 3.1 and 8.4 mg/kg, respectively. In the PK and PD studies, the plasma concentration time profiles of nalbuphine were well fitted to a linear two-compartment open model, and the correlation between pharmacokinetics and pharmacodynamics was significant (p < 0.05). Conclusions : These results suggest that the PPT in rabbits can be used extensively to explore the analgesic effects (PD) of a broad range of analgesics. Also, with this model, PK and PD studies of analgesics can be easily performed.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalActa Anaesthesiologica Sinica
Volume34
Issue number1
Publication statusPublished - Dec 1 1996
Externally publishedYes

Keywords

  • Biopharmaceutics: Pharmacokinetics
  • Disease model: Animal
  • Measurement of pain: Paw pressure test (PPT)
  • Opioid
  • Pain
  • Pharmacology: Pharmacodynamics

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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