Patterns of microstructural white matter abnormalities and their impact on cognitive dysfunction in the various phases of type I bipolar disorder

Paola Magioncalda, Matteo Martino, Benedetta Conio, Niccolò Piaggio, Roxana Oana Teodorescu, Andrea Escelsior, Valentina Marozzi, Giulio Rocchi, Luca Roccatagliata, G. Northoff, Matilde Inglese, Mario Amore

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Abstract

Background In recent years, diffusion tensor imaging (DTI) studies have detected subtle microstructural abnormalities of white matter (WM) in type I bipolar disorder (BD). However, WM alterations in the different phases of BD remain to be explored. The aims of this study is to investigate the WM alterations in the various phases of illness and their correlations with clinical and neurocognitive features. Methods We investigated the DTI-derived fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) in patients with type I BD (n=61) subdivided in manic (n=21), depressive (n=20) and euthymic phases (n=20) vs. healthy controls (n=42), using a tract-based spatial statistics (TBSS) approach. Then, we investigated whether the subgroups of patients in the various phases of illness present different patterns of WM abnormalities. Finally we studied the correlations between WM alterations and clinical-cognitive parameters. Results We found a widespread alteration in WM microstructure (decrease in FA and increase in MD and RD) in BD when compared to controls. The various subgroups of BD showed different spatial patterns of WM alterations. A gradient of increasing WM abnormalities from the euthymic (low degree and localized WM alterations mainly in the midline structures) to the manic (more diffuse WM alterations affecting both midline and lateral structures) and, finally, to the depressive phase (high degree and widespread WM alterations), was found. Furthermore, the WM diffuse alterations correlated with cognitive deficits in BD, such as decreased fluency prompted by letter and decreased hits and increased omission errors at the continuous performance test. Limitations Patients under treatment. Conclusions The WM alterations in type I BD showed different spatial patterns in the various phases of illness, mainly affecting the active phases, and correlated with some cognitive deficits. This suggests a complex trait- and state-dependent pathogenesis of WM abnormalities in BD
Original languageEnglish
Pages (from-to)39-50
Number of pages12
JournalJournal of Affective Disorders
Volume193
DOIs
Publication statusPublished - 2016

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Bipolar Disorder
Diffusion Tensor Imaging
Anisotropy
White Matter
Cognitive Dysfunction

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Patterns of microstructural white matter abnormalities and their impact on cognitive dysfunction in the various phases of type I bipolar disorder. / Magioncalda, Paola; Martino, Matteo; Conio, Benedetta; Piaggio, Niccolò; Teodorescu, Roxana Oana; Escelsior, Andrea; Marozzi, Valentina; Rocchi, Giulio; Roccatagliata, Luca; Northoff, G.; Inglese, Matilde; Amore, Mario.

In: Journal of Affective Disorders, Vol. 193, 2016, p. 39-50.

Research output: Contribution to journalArticle

Magioncalda, P, Martino, M, Conio, B, Piaggio, N, Teodorescu, RO, Escelsior, A, Marozzi, V, Rocchi, G, Roccatagliata, L, Northoff, G, Inglese, M & Amore, M 2016, 'Patterns of microstructural white matter abnormalities and their impact on cognitive dysfunction in the various phases of type I bipolar disorder', Journal of Affective Disorders, vol. 193, pp. 39-50. https://doi.org/10.1016/j.jad.2015.12.050
Magioncalda, Paola ; Martino, Matteo ; Conio, Benedetta ; Piaggio, Niccolò ; Teodorescu, Roxana Oana ; Escelsior, Andrea ; Marozzi, Valentina ; Rocchi, Giulio ; Roccatagliata, Luca ; Northoff, G. ; Inglese, Matilde ; Amore, Mario. / Patterns of microstructural white matter abnormalities and their impact on cognitive dysfunction in the various phases of type I bipolar disorder. In: Journal of Affective Disorders. 2016 ; Vol. 193. pp. 39-50.
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T1 - Patterns of microstructural white matter abnormalities and their impact on cognitive dysfunction in the various phases of type I bipolar disorder

AU - Magioncalda, Paola

AU - Martino, Matteo

AU - Conio, Benedetta

AU - Piaggio, Niccolò

AU - Teodorescu, Roxana Oana

AU - Escelsior, Andrea

AU - Marozzi, Valentina

AU - Rocchi, Giulio

AU - Roccatagliata, Luca

AU - Northoff, G.

AU - Inglese, Matilde

AU - Amore, Mario

N1 - Export Date: 30 March 2016

PY - 2016

Y1 - 2016

N2 - Background In recent years, diffusion tensor imaging (DTI) studies have detected subtle microstructural abnormalities of white matter (WM) in type I bipolar disorder (BD). However, WM alterations in the different phases of BD remain to be explored. The aims of this study is to investigate the WM alterations in the various phases of illness and their correlations with clinical and neurocognitive features. Methods We investigated the DTI-derived fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) in patients with type I BD (n=61) subdivided in manic (n=21), depressive (n=20) and euthymic phases (n=20) vs. healthy controls (n=42), using a tract-based spatial statistics (TBSS) approach. Then, we investigated whether the subgroups of patients in the various phases of illness present different patterns of WM abnormalities. Finally we studied the correlations between WM alterations and clinical-cognitive parameters. Results We found a widespread alteration in WM microstructure (decrease in FA and increase in MD and RD) in BD when compared to controls. The various subgroups of BD showed different spatial patterns of WM alterations. A gradient of increasing WM abnormalities from the euthymic (low degree and localized WM alterations mainly in the midline structures) to the manic (more diffuse WM alterations affecting both midline and lateral structures) and, finally, to the depressive phase (high degree and widespread WM alterations), was found. Furthermore, the WM diffuse alterations correlated with cognitive deficits in BD, such as decreased fluency prompted by letter and decreased hits and increased omission errors at the continuous performance test. Limitations Patients under treatment. Conclusions The WM alterations in type I BD showed different spatial patterns in the various phases of illness, mainly affecting the active phases, and correlated with some cognitive deficits. This suggests a complex trait- and state-dependent pathogenesis of WM abnormalities in BD

AB - Background In recent years, diffusion tensor imaging (DTI) studies have detected subtle microstructural abnormalities of white matter (WM) in type I bipolar disorder (BD). However, WM alterations in the different phases of BD remain to be explored. The aims of this study is to investigate the WM alterations in the various phases of illness and their correlations with clinical and neurocognitive features. Methods We investigated the DTI-derived fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) in patients with type I BD (n=61) subdivided in manic (n=21), depressive (n=20) and euthymic phases (n=20) vs. healthy controls (n=42), using a tract-based spatial statistics (TBSS) approach. Then, we investigated whether the subgroups of patients in the various phases of illness present different patterns of WM abnormalities. Finally we studied the correlations between WM alterations and clinical-cognitive parameters. Results We found a widespread alteration in WM microstructure (decrease in FA and increase in MD and RD) in BD when compared to controls. The various subgroups of BD showed different spatial patterns of WM alterations. A gradient of increasing WM abnormalities from the euthymic (low degree and localized WM alterations mainly in the midline structures) to the manic (more diffuse WM alterations affecting both midline and lateral structures) and, finally, to the depressive phase (high degree and widespread WM alterations), was found. Furthermore, the WM diffuse alterations correlated with cognitive deficits in BD, such as decreased fluency prompted by letter and decreased hits and increased omission errors at the continuous performance test. Limitations Patients under treatment. Conclusions The WM alterations in type I BD showed different spatial patterns in the various phases of illness, mainly affecting the active phases, and correlated with some cognitive deficits. This suggests a complex trait- and state-dependent pathogenesis of WM abnormalities in BD

U2 - 10.1016/j.jad.2015.12.050

DO - 10.1016/j.jad.2015.12.050

M3 - Article

VL - 193

SP - 39

EP - 50

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -