Abstract

Background and Purpose-Previous studies have identified an array of morbidities following traumatic bran injury (TBI), including certain neurological disorders. However, no direct evidence has been reported on the link between TBI and stroke. This population-based study was designed to estimate the risk of stroke during a period of 5 years following a TBI, compared with individuals who did not suffer TBI during the same period. Methods-Data were obtained from the Longitudinal Health Insurance Database 2000 (LHID 2000). A total of 23 199 patients receiving ambulatory or hospitalization care with a diagnosis of TBI were included, together with 69 597 non-TBI patients as our comparison group, matched by sex, age, and year of index use of health care. Each individual was followed for 5 years to identify subsequent occurrence of stroke. Cox proportional hazard regressions were performed for analysis. RESULTS-: During the 3-month follow-up period, 675 strokes (2.91%) occurred in TBI patients and in 207 patients (0.30%) in the non-TBI comparison cohort. A diagnosis of TBI was independently associated with a 10.21 (95% CI, 8.71-11.96), 4.61 (95% CI, 4.16-5.11), and 2.32 (95% CI, 2.17-2.47) times greater risk of stroke during 3-month, 1-year, and 5-year follow-up, respectively, after adjusting for sociodemographic characteristics and selected comorbidities. The risk of intracerebral hemorrhage was more noticeable among patients with TBI compared with those without a TBI. Conclusions-This is the first report showing an increased risk of stroke among individuals who have sustained a TBI. We suggest a need for more intensive medical monitoring and health education following TBI, especially during the first few months and years.

Original languageEnglish
Pages (from-to)2733-2739
Number of pages7
JournalStroke
Volume42
Issue number10
DOIs
Publication statusPublished - Oct 2011

Fingerprint

Stroke
Wounds and Injuries
Population
Traumatic Brain Injury
Cerebral Hemorrhage
Health Insurance
Medical Education
Nervous System Diseases
Health Education
Comorbidity
Hospitalization
Research Design
Databases
Morbidity
Delivery of Health Care

Keywords

  • epidemiology
  • stroke
  • Traumatic brain injury

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialised Nursing

Cite this

Patients with traumatic brain injury : Population-based study suggests increased risk of stroke. / Chen, Yi Hua; Kang, Jiunn Horng; Lin, Herng Ching.

In: Stroke, Vol. 42, No. 10, 10.2011, p. 2733-2739.

Research output: Contribution to journalArticle

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abstract = "Background and Purpose-Previous studies have identified an array of morbidities following traumatic bran injury (TBI), including certain neurological disorders. However, no direct evidence has been reported on the link between TBI and stroke. This population-based study was designed to estimate the risk of stroke during a period of 5 years following a TBI, compared with individuals who did not suffer TBI during the same period. Methods-Data were obtained from the Longitudinal Health Insurance Database 2000 (LHID 2000). A total of 23 199 patients receiving ambulatory or hospitalization care with a diagnosis of TBI were included, together with 69 597 non-TBI patients as our comparison group, matched by sex, age, and year of index use of health care. Each individual was followed for 5 years to identify subsequent occurrence of stroke. Cox proportional hazard regressions were performed for analysis. RESULTS-: During the 3-month follow-up period, 675 strokes (2.91{\%}) occurred in TBI patients and in 207 patients (0.30{\%}) in the non-TBI comparison cohort. A diagnosis of TBI was independently associated with a 10.21 (95{\%} CI, 8.71-11.96), 4.61 (95{\%} CI, 4.16-5.11), and 2.32 (95{\%} CI, 2.17-2.47) times greater risk of stroke during 3-month, 1-year, and 5-year follow-up, respectively, after adjusting for sociodemographic characteristics and selected comorbidities. The risk of intracerebral hemorrhage was more noticeable among patients with TBI compared with those without a TBI. Conclusions-This is the first report showing an increased risk of stroke among individuals who have sustained a TBI. We suggest a need for more intensive medical monitoring and health education following TBI, especially during the first few months and years.",
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