Patients with chronic periodontitis are more likely to develop upper urinary tract stone

A nation-wide populationbased eight-year follow up study

I. Shen Huang, Sung En Huang, Wei Tang Kao, Cheng Yen Chiang, To Chang, Cheng I. Lin, Alex T. Lin, Chih Chieh Lin, Yu Hua Fan, Hsiao Jen Chung

Research output: Contribution to journalArticle

Abstract

Background. The purpose of this study was to investigate the relationship between chronic periodontitis (CP) and upper urinary tract stone (UUTS) in Taiwan by using a population-based data set. Methods. A total of 16,292 CP patients and 48,876 randomly-selected controls without chronic periodontitis were selected from the National research database and studied retrospectively. Subjects selected have not been diagnosed with UUTS previously. These subjects were prospectively followed for at least eight years. Cox regression models were used to explore the connection between risk factors and the development of UUTS. Results. The CP patients have a greater chance of developing UUTS compared to controls (1761/16292, 10.8% vs. 4775/48876, 9.8%, p-values < 0.001). Conditioned logistic regression suggested CP increases the risk of UUTS development (HR 1.14, 95% CI [1.08-1.20], p < 0.001). After respective adjustment for age, gender, hypertension and diabetes, results showed that CP still increases the risk of developing UUTS (HR 1.14, 95% CI [1.08-1.20], p < 0.001). Conclusion. By using a population-based database with a minimum eight 8 follow-up of CP in Taiwan, we discovered patients with CP are more likely to develop UUTS.

Original languageEnglish
Article numbere5287
JournalPeerJ
Volume2018
Issue number7
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

urinary calculi
Chronic Periodontitis
Urinary Calculi
Medical problems
Logistics
Taiwan
Databases
periodontitis
Proportional Hazards Models
Population
hypertension
diabetes
risk factors
Logistic Models
Hypertension
gender

Keywords

  • Chronic periodontitis
  • Upper urinary tract stone
  • Urolithiasis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Patients with chronic periodontitis are more likely to develop upper urinary tract stone : A nation-wide populationbased eight-year follow up study. / Huang, I. Shen; Huang, Sung En; Kao, Wei Tang; Chiang, Cheng Yen; Chang, To; Lin, Cheng I.; Lin, Alex T.; Lin, Chih Chieh; Fan, Yu Hua; Chung, Hsiao Jen.

In: PeerJ, Vol. 2018, No. 7, e5287, 01.01.2018.

Research output: Contribution to journalArticle

Huang, I. Shen ; Huang, Sung En ; Kao, Wei Tang ; Chiang, Cheng Yen ; Chang, To ; Lin, Cheng I. ; Lin, Alex T. ; Lin, Chih Chieh ; Fan, Yu Hua ; Chung, Hsiao Jen. / Patients with chronic periodontitis are more likely to develop upper urinary tract stone : A nation-wide populationbased eight-year follow up study. In: PeerJ. 2018 ; Vol. 2018, No. 7.
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