Abstract

Androgen deprivation therapy (ADT) results in testosterone suppression, a hypothesized mechanism linking ADT to depressive symptoms. This study investigated the relationship between ADT and the risk of subsequently being diagnosed with depressive disorder (DD) during a 3-year follow-up period. The patient sample for this population-based, retrospective cohort study was retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We included all 1714 patients aged over 40 years with a first-time diagnosis of prostate cancer (PC) during 2001 to 2010 who did not have an orchiectomy. Among them, we defined 868 patients who received ADT during the 3-year follow-up period as the study group, and 846 patients who did not receive ADT as the comparison group. The incidence rates of DD per 1000 person-years were 13.9 (95% confidence interval (CI): 9.5∼19.6) and 6.7 (95% CI: 3.7∼11.0), respectively. Cox proportional hazard regressions showed that the adjusted hazard ratio for DD for ADT recipients was 1.93 (95% CI: 1.03∼3.62) relative to the comparison group. This study presents epidemiological evidence of an association between ADT and a subsequent DD diagnosis.

Original languageEnglish
Article numbere0173266
JournalPLoS One
Volume12
Issue number3
DOIs
Publication statusPublished - Mar 1 2017

Fingerprint

prostatic neoplasms
Depressive Disorder
androgens
Androgens
Prostatic Neoplasms
therapeutics
confidence interval
Confidence Intervals
Therapeutics
Hazards
Health insurance
health insurance
Orchiectomy
castration
Health Insurance
cohort studies
Taiwan
epidemiological studies
signs and symptoms (animals and humans)
testosterone

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Patients receiving androgen deprivation therapy for prostate cancer have an increased risk of depressive disorder. / Chung, Shiu Dong; Kao, Li Ting; Lin, Herng Ching; Xirasagar, Sudha; Huang, Chung Chien; Lee, Hsin Chien.

In: PLoS One, Vol. 12, No. 3, e0173266, 01.03.2017.

Research output: Contribution to journalArticle

@article{aeea63756b5145a6a5c9bcb2af2ac6c2,
title = "Patients receiving androgen deprivation therapy for prostate cancer have an increased risk of depressive disorder",
abstract = "Androgen deprivation therapy (ADT) results in testosterone suppression, a hypothesized mechanism linking ADT to depressive symptoms. This study investigated the relationship between ADT and the risk of subsequently being diagnosed with depressive disorder (DD) during a 3-year follow-up period. The patient sample for this population-based, retrospective cohort study was retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We included all 1714 patients aged over 40 years with a first-time diagnosis of prostate cancer (PC) during 2001 to 2010 who did not have an orchiectomy. Among them, we defined 868 patients who received ADT during the 3-year follow-up period as the study group, and 846 patients who did not receive ADT as the comparison group. The incidence rates of DD per 1000 person-years were 13.9 (95{\%} confidence interval (CI): 9.5∼19.6) and 6.7 (95{\%} CI: 3.7∼11.0), respectively. Cox proportional hazard regressions showed that the adjusted hazard ratio for DD for ADT recipients was 1.93 (95{\%} CI: 1.03∼3.62) relative to the comparison group. This study presents epidemiological evidence of an association between ADT and a subsequent DD diagnosis.",
author = "Chung, {Shiu Dong} and Kao, {Li Ting} and Lin, {Herng Ching} and Sudha Xirasagar and Huang, {Chung Chien} and Lee, {Hsin Chien}",
year = "2017",
month = "3",
day = "1",
doi = "10.1371/journal.pone.0173266",
language = "English",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

TY - JOUR

T1 - Patients receiving androgen deprivation therapy for prostate cancer have an increased risk of depressive disorder

AU - Chung, Shiu Dong

AU - Kao, Li Ting

AU - Lin, Herng Ching

AU - Xirasagar, Sudha

AU - Huang, Chung Chien

AU - Lee, Hsin Chien

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Androgen deprivation therapy (ADT) results in testosterone suppression, a hypothesized mechanism linking ADT to depressive symptoms. This study investigated the relationship between ADT and the risk of subsequently being diagnosed with depressive disorder (DD) during a 3-year follow-up period. The patient sample for this population-based, retrospective cohort study was retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We included all 1714 patients aged over 40 years with a first-time diagnosis of prostate cancer (PC) during 2001 to 2010 who did not have an orchiectomy. Among them, we defined 868 patients who received ADT during the 3-year follow-up period as the study group, and 846 patients who did not receive ADT as the comparison group. The incidence rates of DD per 1000 person-years were 13.9 (95% confidence interval (CI): 9.5∼19.6) and 6.7 (95% CI: 3.7∼11.0), respectively. Cox proportional hazard regressions showed that the adjusted hazard ratio for DD for ADT recipients was 1.93 (95% CI: 1.03∼3.62) relative to the comparison group. This study presents epidemiological evidence of an association between ADT and a subsequent DD diagnosis.

AB - Androgen deprivation therapy (ADT) results in testosterone suppression, a hypothesized mechanism linking ADT to depressive symptoms. This study investigated the relationship between ADT and the risk of subsequently being diagnosed with depressive disorder (DD) during a 3-year follow-up period. The patient sample for this population-based, retrospective cohort study was retrieved from the Taiwan Longitudinal Health Insurance Database 2005. We included all 1714 patients aged over 40 years with a first-time diagnosis of prostate cancer (PC) during 2001 to 2010 who did not have an orchiectomy. Among them, we defined 868 patients who received ADT during the 3-year follow-up period as the study group, and 846 patients who did not receive ADT as the comparison group. The incidence rates of DD per 1000 person-years were 13.9 (95% confidence interval (CI): 9.5∼19.6) and 6.7 (95% CI: 3.7∼11.0), respectively. Cox proportional hazard regressions showed that the adjusted hazard ratio for DD for ADT recipients was 1.93 (95% CI: 1.03∼3.62) relative to the comparison group. This study presents epidemiological evidence of an association between ADT and a subsequent DD diagnosis.

UR - http://www.scopus.com/inward/record.url?scp=85014380561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85014380561&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0173266

DO - 10.1371/journal.pone.0173266

M3 - Article

C2 - 28253340

AN - SCOPUS:85014380561

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 3

M1 - e0173266

ER -