Patient Characteristics and Treatment Discontinuation in a Taiwanese Cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) Study

Mong-Liang Lu, Chaucer Lin, Cheng Cheng Hsiao, Yu-Shu Huang, Shao-Chun Ree, Ruu Fen Tzang, Sy-Ueng Luu, Teena Maree West, Winston W. Shen

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Abstract

Objective: This report was to present the demographic and clinical outcomes of the Taiwanese cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study for the readership of Taiwanese psychiatrists. Methods: The IC-SOHO was a three-year, naturalistic, prospective, observational study which was designed to compare outcomes of outpatients with schizophrenia who had initiated or changed antipsychotic medications. They were divided into olanzapine and other non-olanzapine antipsychotic groups. Evaluations included clinical severity, social functioning, health-related quality of life, and medication tolerability. Time to treatment discontinuation was analyzed using the Kaplan-Meier method. Results: A total of 300 patients was enrolled in this Taiwanese cohort, and 81.6% (245 patients) of them received initial antipsychotic monotherapy. Despite the absence of randomization in this study, no signifi cant differences were found between the treatment cohorts in the socio-demographic and clinical characteristics at baseline of those two groups. The mean doses of treatments were increased in those two groups over the 36-month period and the uses of non-antipsychotic concomitant medications remained high throughout the study. Patients who remained at the end of the study showed a clinical response to treatment indicated by reductions in CGI-S scores in all domains, but these changes were not signifi cantly different between those two groups. The estimated time to medication discontinuation for 50% of patients was 36.3 (95% CI 31.2, 38.4) months for those in the olanzapine group and 18.0 (95% CI 11.3, 30.1) months for patients receiving other monotherapy; the hazard ratio was 0.65 (95% CI 0.43, 0.99). But their weight gain was signifi cantly greater for the olanzapine group over the fi rst 12 months of treatment. Conclusion: The results of this naturalistic, observational study offer an important description of the clinical characteristics and outcomes associated with the long-term use of antipsychotic treatment of schizophrenia in a cohort of Taiwanese patients.

Patient Characteristics and Treatment Discontinuation in a Taiwanese Cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) Study (PDF Download Available). Available from: https://www.researchgate.net/publication/259604009_Patient_Characteristics_and_Treatment_Discontinuation_in_a_Taiwanese_Cohort_of_the_Intercontinental_Schizophrenia_Outpatient_Health_Outcomes_IC-SOHO_Study [accessed Jul 24, 2017].
Original languageEnglish
Pages (from-to)110-121
Number of pages12
JournalTaiwanese Journal of Psychiatry (Taipei)
Volume24
Issue number2
Publication statusPublished - Jan 2010

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Schizophrenia
Outpatients
olanzapine
Outcome Assessment (Health Care)
Health
Antipsychotic Agents
Therapeutics
Observational Studies
Demography
Random Allocation
Weight Gain
Psychiatry
Publications
Quality of Life
Prospective Studies

Keywords

  • Schizophrenia
  • observational study
  • time to discontinuation
  • Olanzapine

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Patient Characteristics and Treatment Discontinuation in a Taiwanese Cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) Study. / Lu, Mong-Liang; Lin, Chaucer; Hsiao, Cheng Cheng; Huang, Yu-Shu; Ree, Shao-Chun; Tzang, Ruu Fen; Luu, Sy-Ueng ; West, Teena Maree ; Shen, Winston W.

In: Taiwanese Journal of Psychiatry (Taipei), Vol. 24, No. 2, 01.2010, p. 110-121.

Research output: Contribution to journalArticle

Lu, Mong-Liang ; Lin, Chaucer ; Hsiao, Cheng Cheng ; Huang, Yu-Shu ; Ree, Shao-Chun ; Tzang, Ruu Fen ; Luu, Sy-Ueng ; West, Teena Maree ; Shen, Winston W. / Patient Characteristics and Treatment Discontinuation in a Taiwanese Cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) Study. In: Taiwanese Journal of Psychiatry (Taipei). 2010 ; Vol. 24, No. 2. pp. 110-121.
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AU - Lu, Mong-Liang

AU - Lin, Chaucer

AU - Hsiao, Cheng Cheng

AU - Huang, Yu-Shu

AU - Ree, Shao-Chun

AU - Tzang, Ruu Fen

AU - Luu, Sy-Ueng

AU - West, Teena Maree

AU - Shen, Winston W.

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N2 - Objective: This report was to present the demographic and clinical outcomes of the Taiwanese cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study for the readership of Taiwanese psychiatrists. Methods: The IC-SOHO was a three-year, naturalistic, prospective, observational study which was designed to compare outcomes of outpatients with schizophrenia who had initiated or changed antipsychotic medications. They were divided into olanzapine and other non-olanzapine antipsychotic groups. Evaluations included clinical severity, social functioning, health-related quality of life, and medication tolerability. Time to treatment discontinuation was analyzed using the Kaplan-Meier method. Results: A total of 300 patients was enrolled in this Taiwanese cohort, and 81.6% (245 patients) of them received initial antipsychotic monotherapy. Despite the absence of randomization in this study, no signifi cant differences were found between the treatment cohorts in the socio-demographic and clinical characteristics at baseline of those two groups. The mean doses of treatments were increased in those two groups over the 36-month period and the uses of non-antipsychotic concomitant medications remained high throughout the study. Patients who remained at the end of the study showed a clinical response to treatment indicated by reductions in CGI-S scores in all domains, but these changes were not signifi cantly different between those two groups. The estimated time to medication discontinuation for 50% of patients was 36.3 (95% CI 31.2, 38.4) months for those in the olanzapine group and 18.0 (95% CI 11.3, 30.1) months for patients receiving other monotherapy; the hazard ratio was 0.65 (95% CI 0.43, 0.99). But their weight gain was signifi cantly greater for the olanzapine group over the fi rst 12 months of treatment. Conclusion: The results of this naturalistic, observational study offer an important description of the clinical characteristics and outcomes associated with the long-term use of antipsychotic treatment of schizophrenia in a cohort of Taiwanese patients. Patient Characteristics and Treatment Discontinuation in a Taiwanese Cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) Study (PDF Download Available). Available from: https://www.researchgate.net/publication/259604009_Patient_Characteristics_and_Treatment_Discontinuation_in_a_Taiwanese_Cohort_of_the_Intercontinental_Schizophrenia_Outpatient_Health_Outcomes_IC-SOHO_Study [accessed Jul 24, 2017].

AB - Objective: This report was to present the demographic and clinical outcomes of the Taiwanese cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study for the readership of Taiwanese psychiatrists. Methods: The IC-SOHO was a three-year, naturalistic, prospective, observational study which was designed to compare outcomes of outpatients with schizophrenia who had initiated or changed antipsychotic medications. They were divided into olanzapine and other non-olanzapine antipsychotic groups. Evaluations included clinical severity, social functioning, health-related quality of life, and medication tolerability. Time to treatment discontinuation was analyzed using the Kaplan-Meier method. Results: A total of 300 patients was enrolled in this Taiwanese cohort, and 81.6% (245 patients) of them received initial antipsychotic monotherapy. Despite the absence of randomization in this study, no signifi cant differences were found between the treatment cohorts in the socio-demographic and clinical characteristics at baseline of those two groups. The mean doses of treatments were increased in those two groups over the 36-month period and the uses of non-antipsychotic concomitant medications remained high throughout the study. Patients who remained at the end of the study showed a clinical response to treatment indicated by reductions in CGI-S scores in all domains, but these changes were not signifi cantly different between those two groups. The estimated time to medication discontinuation for 50% of patients was 36.3 (95% CI 31.2, 38.4) months for those in the olanzapine group and 18.0 (95% CI 11.3, 30.1) months for patients receiving other monotherapy; the hazard ratio was 0.65 (95% CI 0.43, 0.99). But their weight gain was signifi cantly greater for the olanzapine group over the fi rst 12 months of treatment. Conclusion: The results of this naturalistic, observational study offer an important description of the clinical characteristics and outcomes associated with the long-term use of antipsychotic treatment of schizophrenia in a cohort of Taiwanese patients. Patient Characteristics and Treatment Discontinuation in a Taiwanese Cohort of the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) Study (PDF Download Available). Available from: https://www.researchgate.net/publication/259604009_Patient_Characteristics_and_Treatment_Discontinuation_in_a_Taiwanese_Cohort_of_the_Intercontinental_Schizophrenia_Outpatient_Health_Outcomes_IC-SOHO_Study [accessed Jul 24, 2017].

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KW - time to discontinuation

KW - Olanzapine

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JO - Taiwanese Journal of Psychiatry (Taipei)

JF - Taiwanese Journal of Psychiatry (Taipei)

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