Pathogen survival in the external environment and the evolution of virulence

Bruno A. Walther, Paul W. Ewald

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Recent studies have provided evolutionary explanations for much of the variation in mortality among human infectious diseases. One gap in this knowledge concerns respiratory tract pathogens transmitted from person to person by direct contact or through environmental contamination. The sit-and-wait hypothesis predicts that virulence should be positively correlated with durability in the external environment because high durability reduces the dependence of transmission on host mobility. Reviewing the epidemiological and medical literature, we confirm this prediction for respiratory tract pathogens of humans. Our results clearly distinguish a high-virulence high-survival group of variola (smallpox) virus, Mycobacterium tuberculosis, Corynebacterium diphtheriae, Bordetella pertussis, Streptococcus pneumoniae, and influenza virus (where all pathogens have a mean percent mortality ≥ 0.01% and mean survival time > 10 days) from a low-virulence low-survival group containing ten other pathogens. The correlation between virulence and durability explains three to four times of magnitude of difference in mean percent mortality and mean survival time, using both across-species and phylogenetically controlled analyses. Our findings bear on several areas of active research and public health policy. (1) many pathogens used in the biological control of insects are potential sit-and-wait pathogens as they combine three attributes that are advantageous for pest control: high virulence, long durability after application, and host specificity; (2) emerging pathogens such as the 'hospital superbug' methicillin-resistant Staphylococcus aureus (MRSA) and potential bio-weapons pathogens such as smallpox virus and anthrax that are particularly dangerous can be discerned by quantifying their durability: (3) hospital settings and the AIDS pandemic may provide footholds for emerging sit-and-wait pathogens; and (4) studies on food-borne and insect pathogens point to future research considering the potential evolutionary trade-offs and genetic linkages between virulence and durability.

Original languageEnglish
Pages (from-to)849-869
Number of pages21
JournalBiological Reviews of the Cambridge Philosophical Society
Volume79
Issue number4
DOIs
Publication statusPublished - Nov 2004
Externally publishedYes

Fingerprint

pathogen survival
Pathogens
Virulence
virulence
Variola virus
durability
Survival
pathogens
Durability
Respiratory System
Viruses
Mortality
Survival Rate
Corynebacterium diphtheriae
Insect Control
respiratory system
Bordetella pertussis
Anthrax
Pest Control
Genetic Linkage

Keywords

  • Durability
  • Evolution
  • Infectious disease
  • Mortality
  • Sit-and-wait pathogens
  • Transmission
  • Virulence

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)

Cite this

Pathogen survival in the external environment and the evolution of virulence. / Walther, Bruno A.; Ewald, Paul W.

In: Biological Reviews of the Cambridge Philosophical Society, Vol. 79, No. 4, 11.2004, p. 849-869.

Research output: Contribution to journalArticle

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