Patency rates of cuffed and noncuffed extended polytetrafluoroethylene grafts in dialysis access

A prospective, randomized study

Po J. Ko, Yun H. Liu, Yen N. Hung, Hung Chang Hsieh

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Although autogenous arteriovenous fistulae are the optimal route for dialysis access, extended polytetrafluoroethylene (ePTFE) grafts continue to be the preferred access for patients without suitable superficial veins. Among the common complications related to dialysis grafts, thrombosis due to graft outlet stenosis is the most frequently encountered clinical problem. A cuffed graft was designed to eliminate the outflow turbulence to reduce outlet stenosis and to enhance the clinical patency of ePTFE grafts. We conducted a prospective, randomized study to compare the clinical outcomes of cuffed ePTFE grafts and noncuffed grafts in dialysis access. Methods: Between November 2004 and October 2005, 89 ePTFE grafts were implanted for hemodialysis access in the upper extremities of end-stage renal patients. Graft selection was randomized, with patients receiving a cuffed graft (Venaflo) or a regular noncuffed graft (Stretch Gore-Tex). All patients were monitored for signs of thrombosis or other complications. Primary and secondary graft patency was analyzed by using a life-table analysis, and the log-rank test was applied to compare graft patencies. Results: Demographic data for both groups were similar without statistical difference. The primary patency rates and secondary patency rates at 12 months after implantation were 56% and 91% for cuffed grafts, and 41% and 78% for noncuffed grafts, respectively. The cuffed group outperforms the noncuffed group regarding primary and secondary patencies statistically. However, the incidence of other complications that required further surgery was similar in both groups. Conclusions: This investigation revealed that the cuffed ePTFE graft, which was designed to decrease graft outlet stenosis, may enhance the clinical patency rates of dialysis grafts.

Original languageEnglish
Pages (from-to)846-851
Number of pages6
JournalWorld Journal of Surgery
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

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Polytetrafluoroethylene
Dialysis
Prospective Studies
Transplants
Pathologic Constriction
Thrombosis
Life Tables
Arteriovenous Fistula

ASJC Scopus subject areas

  • Surgery

Cite this

Patency rates of cuffed and noncuffed extended polytetrafluoroethylene grafts in dialysis access : A prospective, randomized study. / Ko, Po J.; Liu, Yun H.; Hung, Yen N.; Hsieh, Hung Chang.

In: World Journal of Surgery, Vol. 33, No. 4, 04.2009, p. 846-851.

Research output: Contribution to journalArticle

Ko, Po J. ; Liu, Yun H. ; Hung, Yen N. ; Hsieh, Hung Chang. / Patency rates of cuffed and noncuffed extended polytetrafluoroethylene grafts in dialysis access : A prospective, randomized study. In: World Journal of Surgery. 2009 ; Vol. 33, No. 4. pp. 846-851.
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abstract = "Background: Although autogenous arteriovenous fistulae are the optimal route for dialysis access, extended polytetrafluoroethylene (ePTFE) grafts continue to be the preferred access for patients without suitable superficial veins. Among the common complications related to dialysis grafts, thrombosis due to graft outlet stenosis is the most frequently encountered clinical problem. A cuffed graft was designed to eliminate the outflow turbulence to reduce outlet stenosis and to enhance the clinical patency of ePTFE grafts. We conducted a prospective, randomized study to compare the clinical outcomes of cuffed ePTFE grafts and noncuffed grafts in dialysis access. Methods: Between November 2004 and October 2005, 89 ePTFE grafts were implanted for hemodialysis access in the upper extremities of end-stage renal patients. Graft selection was randomized, with patients receiving a cuffed graft (Venaflo) or a regular noncuffed graft (Stretch Gore-Tex). All patients were monitored for signs of thrombosis or other complications. Primary and secondary graft patency was analyzed by using a life-table analysis, and the log-rank test was applied to compare graft patencies. Results: Demographic data for both groups were similar without statistical difference. The primary patency rates and secondary patency rates at 12 months after implantation were 56{\%} and 91{\%} for cuffed grafts, and 41{\%} and 78{\%} for noncuffed grafts, respectively. The cuffed group outperforms the noncuffed group regarding primary and secondary patencies statistically. However, the incidence of other complications that required further surgery was similar in both groups. Conclusions: This investigation revealed that the cuffed ePTFE graft, which was designed to decrease graft outlet stenosis, may enhance the clinical patency rates of dialysis grafts.",
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