Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy: Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging

Cheng Chieh Cheng, Su Chin Chiu, Yee Min Jen, Hing Chiu Chang, Hsiao Wen Chung, Yi Jui Liu, Hui Chu Chiu, Cheng Yu Chen, Guo Shu Huang, Chun Jung Juan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: To investigate parotid perfusion in early-to-intermediate stage after parotid-sparing radiation dose using fat-saturated DCE-MRI, and to verify whether the perfusion alteration was related to radiation dose and the PSV. Methods and Materials: Thirty-two parotid glands from 16 consecutive patients with pathologically proven nasopharyngeal carcinoma treated by IMRT were examined. The parotid glands received a radiation dose of 28.9. ±. 3.9. Gy with a PSV of 43.1%. ±. 13.9%. Perfusion parameters were calculated using time-shifted Brix model from fat-saturated DCE-MRI data before (pre-RT) and in early-to-intermediate stage after (post-RT) IMRT. Paired t-test was used to evaluate perfusion changes, while Pearson's correlation test was used to examine perfusion dependency on radiation dose and PSV. For multiple comparisons Bonferroni correction was applied. Results: Successful fat saturation was achieved in 29 of 32 parotid glands. Compared with pre-RT, the post-RT parotid glands showed significantly higher A, peak enhancement, and wash-in slope, plus a lower Kel, suggesting a mixed effect of increased vascular permeability and acinar loss. Linear regression showed that peak enhancement was positively associated with radiation dose in post-RT parotid glands. Kel and slope were negatively associated with PSV, while time-to-peak was positively associated with PSV significantly. Conclusions: Our results suggest that time-shifted Brix model is feasible for quantifying parotid perfusion using DCE-MRI. The perfusion alterations in early-to-intermediate stage after IMRT might be related to a mixed effect of increased vascular permeability and acinar loss with dose and PSV dependencies.

Original languageEnglish
Pages (from-to)1278-1284
Number of pages7
JournalMagnetic Resonance Imaging
Volume31
Issue number8
DOIs
Publication statusPublished - Oct 2013
Externally publishedYes

Fingerprint

Intensity-Modulated Radiotherapy
Radiotherapy
Magnetic resonance
Oils and fats
Dosimetry
Parotid Gland
Perfusion
Fats
Magnetic Resonance Imaging
Imaging techniques
Magnetic resonance imaging
Radiation
Capillary Permeability
Linear regression
Nasopharyngeal carcinoma
Linear Models

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

Cite this

Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy : Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging. / Cheng, Cheng Chieh; Chiu, Su Chin; Jen, Yee Min; Chang, Hing Chiu; Chung, Hsiao Wen; Liu, Yi Jui; Chiu, Hui Chu; Chen, Cheng Yu; Huang, Guo Shu; Juan, Chun Jung.

In: Magnetic Resonance Imaging, Vol. 31, No. 8, 10.2013, p. 1278-1284.

Research output: Contribution to journalArticle

Cheng, Cheng Chieh ; Chiu, Su Chin ; Jen, Yee Min ; Chang, Hing Chiu ; Chung, Hsiao Wen ; Liu, Yi Jui ; Chiu, Hui Chu ; Chen, Cheng Yu ; Huang, Guo Shu ; Juan, Chun Jung. / Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy : Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging. In: Magnetic Resonance Imaging. 2013 ; Vol. 31, No. 8. pp. 1278-1284.
@article{3b2505844ca840e594a3f4c30d2202f0,
title = "Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy: Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging",
abstract = "Purpose: To investigate parotid perfusion in early-to-intermediate stage after parotid-sparing radiation dose using fat-saturated DCE-MRI, and to verify whether the perfusion alteration was related to radiation dose and the PSV. Methods and Materials: Thirty-two parotid glands from 16 consecutive patients with pathologically proven nasopharyngeal carcinoma treated by IMRT were examined. The parotid glands received a radiation dose of 28.9. ±. 3.9. Gy with a PSV of 43.1{\%}. ±. 13.9{\%}. Perfusion parameters were calculated using time-shifted Brix model from fat-saturated DCE-MRI data before (pre-RT) and in early-to-intermediate stage after (post-RT) IMRT. Paired t-test was used to evaluate perfusion changes, while Pearson's correlation test was used to examine perfusion dependency on radiation dose and PSV. For multiple comparisons Bonferroni correction was applied. Results: Successful fat saturation was achieved in 29 of 32 parotid glands. Compared with pre-RT, the post-RT parotid glands showed significantly higher A, peak enhancement, and wash-in slope, plus a lower Kel, suggesting a mixed effect of increased vascular permeability and acinar loss. Linear regression showed that peak enhancement was positively associated with radiation dose in post-RT parotid glands. Kel and slope were negatively associated with PSV, while time-to-peak was positively associated with PSV significantly. Conclusions: Our results suggest that time-shifted Brix model is feasible for quantifying parotid perfusion using DCE-MRI. The perfusion alterations in early-to-intermediate stage after IMRT might be related to a mixed effect of increased vascular permeability and acinar loss with dose and PSV dependencies.",
author = "Cheng, {Cheng Chieh} and Chiu, {Su Chin} and Jen, {Yee Min} and Chang, {Hing Chiu} and Chung, {Hsiao Wen} and Liu, {Yi Jui} and Chiu, {Hui Chu} and Chen, {Cheng Yu} and Huang, {Guo Shu} and Juan, {Chun Jung}",
year = "2013",
month = "10",
doi = "10.1016/j.mri.2013.03.018",
language = "English",
volume = "31",
pages = "1278--1284",
journal = "Magnetic Resonance Imaging",
issn = "0730-725X",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Parotid perfusion in nasopharyngeal carcinoma patients in early-to-intermediate stage after low-dose intensity-modulated radiotherapy

T2 - Evaluated by fat-saturated dynamic contrast-enhanced magnetic resonance imaging

AU - Cheng, Cheng Chieh

AU - Chiu, Su Chin

AU - Jen, Yee Min

AU - Chang, Hing Chiu

AU - Chung, Hsiao Wen

AU - Liu, Yi Jui

AU - Chiu, Hui Chu

AU - Chen, Cheng Yu

AU - Huang, Guo Shu

AU - Juan, Chun Jung

PY - 2013/10

Y1 - 2013/10

N2 - Purpose: To investigate parotid perfusion in early-to-intermediate stage after parotid-sparing radiation dose using fat-saturated DCE-MRI, and to verify whether the perfusion alteration was related to radiation dose and the PSV. Methods and Materials: Thirty-two parotid glands from 16 consecutive patients with pathologically proven nasopharyngeal carcinoma treated by IMRT were examined. The parotid glands received a radiation dose of 28.9. ±. 3.9. Gy with a PSV of 43.1%. ±. 13.9%. Perfusion parameters were calculated using time-shifted Brix model from fat-saturated DCE-MRI data before (pre-RT) and in early-to-intermediate stage after (post-RT) IMRT. Paired t-test was used to evaluate perfusion changes, while Pearson's correlation test was used to examine perfusion dependency on radiation dose and PSV. For multiple comparisons Bonferroni correction was applied. Results: Successful fat saturation was achieved in 29 of 32 parotid glands. Compared with pre-RT, the post-RT parotid glands showed significantly higher A, peak enhancement, and wash-in slope, plus a lower Kel, suggesting a mixed effect of increased vascular permeability and acinar loss. Linear regression showed that peak enhancement was positively associated with radiation dose in post-RT parotid glands. Kel and slope were negatively associated with PSV, while time-to-peak was positively associated with PSV significantly. Conclusions: Our results suggest that time-shifted Brix model is feasible for quantifying parotid perfusion using DCE-MRI. The perfusion alterations in early-to-intermediate stage after IMRT might be related to a mixed effect of increased vascular permeability and acinar loss with dose and PSV dependencies.

AB - Purpose: To investigate parotid perfusion in early-to-intermediate stage after parotid-sparing radiation dose using fat-saturated DCE-MRI, and to verify whether the perfusion alteration was related to radiation dose and the PSV. Methods and Materials: Thirty-two parotid glands from 16 consecutive patients with pathologically proven nasopharyngeal carcinoma treated by IMRT were examined. The parotid glands received a radiation dose of 28.9. ±. 3.9. Gy with a PSV of 43.1%. ±. 13.9%. Perfusion parameters were calculated using time-shifted Brix model from fat-saturated DCE-MRI data before (pre-RT) and in early-to-intermediate stage after (post-RT) IMRT. Paired t-test was used to evaluate perfusion changes, while Pearson's correlation test was used to examine perfusion dependency on radiation dose and PSV. For multiple comparisons Bonferroni correction was applied. Results: Successful fat saturation was achieved in 29 of 32 parotid glands. Compared with pre-RT, the post-RT parotid glands showed significantly higher A, peak enhancement, and wash-in slope, plus a lower Kel, suggesting a mixed effect of increased vascular permeability and acinar loss. Linear regression showed that peak enhancement was positively associated with radiation dose in post-RT parotid glands. Kel and slope were negatively associated with PSV, while time-to-peak was positively associated with PSV significantly. Conclusions: Our results suggest that time-shifted Brix model is feasible for quantifying parotid perfusion using DCE-MRI. The perfusion alterations in early-to-intermediate stage after IMRT might be related to a mixed effect of increased vascular permeability and acinar loss with dose and PSV dependencies.

UR - http://www.scopus.com/inward/record.url?scp=84883740913&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883740913&partnerID=8YFLogxK

U2 - 10.1016/j.mri.2013.03.018

DO - 10.1016/j.mri.2013.03.018

M3 - Article

C2 - 23664679

AN - SCOPUS:84883740913

VL - 31

SP - 1278

EP - 1284

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

SN - 0730-725X

IS - 8

ER -