Parkinson's disease is related to an increased risk of ischemic stroke-a population-based propensity score-matched follow-up study

Ya-Ping Huang, Li-Sheng Chen, Ming-Fang Yen, Ching-Yuan Fann, Yueh-Hsia Chiu, Hsiu-Hsi Chen, Shin-Liang Pan

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: The risk of stroke in patients with Parkinson's disease (PD) remains controversial. The purpose of this population-based propensity score-matched longitudinal follow-up study was to determine whether there is an increased risk of ischemic stroke after PD.

METHODS: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 2204 patients with at least two ambulatory visits with the principal diagnosis of PD in 2001 was enrolled in the PD group. The non- PD group consisted of 2204, propensity score-matched subjects without PD. The ischemic stroke-free survival rates of the two groups were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched on propensity score was used to estimate the effect of PD on the occurrence of ischemic stroke.

RESULTS: During the three-year follow-up period, 328 subjects in the PD group and 156 subjects in the non-PD group developed ischemic stroke. The ischemic stroke-free survival rate of the PD group was significantly lower than that of the non-PD group (P<0.0001). The hazard ratio (HR) of stroke for the PD group was 2.37 (95% confidence interval [CI], 1.92 to 2.93, P<0.0001) compared to the non- PD group.

CONCLUSIONS: This study shows a significantly increased risk of ischemic stroke in PD patients. Further studies are required to investigate the underlying mechanism.

Original languageEnglish
Pages (from-to)e68314
JournalPLoS One
Volume8
Issue number9
DOIs
Publication statusPublished - 2013

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Propensity Score
Parkinson disease
stroke
Parkinson Disease
Stroke
Population
Survival Rate
survival rate
Logistic Models
Hazards
socioeconomic status
Social Class
Comorbidity
confidence interval
Logistics

Keywords

  • Aged
  • Aged, 80 and over
  • Female
  • Follow-Up Studies
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Parkinson Disease
  • Propensity Score
  • Prospective Studies
  • Stroke
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Parkinson's disease is related to an increased risk of ischemic stroke-a population-based propensity score-matched follow-up study. / Huang, Ya-Ping; Chen, Li-Sheng; Yen, Ming-Fang; Fann, Ching-Yuan; Chiu, Yueh-Hsia; Chen, Hsiu-Hsi; Pan, Shin-Liang.

In: PLoS One, Vol. 8, No. 9, 2013, p. e68314.

Research output: Contribution to journalArticle

Huang, Ya-Ping ; Chen, Li-Sheng ; Yen, Ming-Fang ; Fann, Ching-Yuan ; Chiu, Yueh-Hsia ; Chen, Hsiu-Hsi ; Pan, Shin-Liang. / Parkinson's disease is related to an increased risk of ischemic stroke-a population-based propensity score-matched follow-up study. In: PLoS One. 2013 ; Vol. 8, No. 9. pp. e68314.
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AU - Huang, Ya-Ping

AU - Chen, Li-Sheng

AU - Yen, Ming-Fang

AU - Fann, Ching-Yuan

AU - Chiu, Yueh-Hsia

AU - Chen, Hsiu-Hsi

AU - Pan, Shin-Liang

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N2 - OBJECTIVE: The risk of stroke in patients with Parkinson's disease (PD) remains controversial. The purpose of this population-based propensity score-matched longitudinal follow-up study was to determine whether there is an increased risk of ischemic stroke after PD.METHODS: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 2204 patients with at least two ambulatory visits with the principal diagnosis of PD in 2001 was enrolled in the PD group. The non- PD group consisted of 2204, propensity score-matched subjects without PD. The ischemic stroke-free survival rates of the two groups were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched on propensity score was used to estimate the effect of PD on the occurrence of ischemic stroke.RESULTS: During the three-year follow-up period, 328 subjects in the PD group and 156 subjects in the non-PD group developed ischemic stroke. The ischemic stroke-free survival rate of the PD group was significantly lower than that of the non-PD group (P<0.0001). The hazard ratio (HR) of stroke for the PD group was 2.37 (95% confidence interval [CI], 1.92 to 2.93, P<0.0001) compared to the non- PD group.CONCLUSIONS: This study shows a significantly increased risk of ischemic stroke in PD patients. Further studies are required to investigate the underlying mechanism.

AB - OBJECTIVE: The risk of stroke in patients with Parkinson's disease (PD) remains controversial. The purpose of this population-based propensity score-matched longitudinal follow-up study was to determine whether there is an increased risk of ischemic stroke after PD.METHODS: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 2204 patients with at least two ambulatory visits with the principal diagnosis of PD in 2001 was enrolled in the PD group. The non- PD group consisted of 2204, propensity score-matched subjects without PD. The ischemic stroke-free survival rates of the two groups were estimated using the Kaplan-Meier method. Stratified Cox proportional hazard regression with patients matched on propensity score was used to estimate the effect of PD on the occurrence of ischemic stroke.RESULTS: During the three-year follow-up period, 328 subjects in the PD group and 156 subjects in the non-PD group developed ischemic stroke. The ischemic stroke-free survival rate of the PD group was significantly lower than that of the non-PD group (P<0.0001). The hazard ratio (HR) of stroke for the PD group was 2.37 (95% confidence interval [CI], 1.92 to 2.93, P<0.0001) compared to the non- PD group.CONCLUSIONS: This study shows a significantly increased risk of ischemic stroke in PD patients. Further studies are required to investigate the underlying mechanism.

KW - Aged

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KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

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KW - Propensity Score

KW - Prospective Studies

KW - Stroke

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

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SN - 1932-6203

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ER -