Parasympathetic activity correlates with early outcome in patients with large artery atherosclerotic stroke

Po Lin Chen, Terry B J Kuo, Cheryl C H Yang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

To evaluate the associations between autonomic function and early stroke outcome in different subtypes of cerebral infarct, 24 patients with acute large artery atherosclerotic infarction (LAA), 26 patients with acute lacunar infarction (LAC), and 19 control subjects were prospectively recruited. Stroke outcome by the National Institute of Health Stroke Score (NIHSS) and heart rate variability (HRV) by power spectral analysis were recorded. The LAA group had lower high-frequency power (HF, P = 0.017), lower normalized HF (P = 0.002), higher normalized low-frequency power (LF%, P = 0.016), and higher ratio of LF to HF (P = 0.003) than both the LAC and control groups. Multivariate regression analysis in the LAA group showed that HF significantly correlated with early outcome (standardized coefficient = - 0.486, P = 0.016), and HF less than 3.9 [ln(ms 2)] was an independent risk factor for NIHSS ≥ 4 at seventh day after admission (odd ratio = 6.00, 95% confidence interval 1.02-35.37, P = 0.048). There was no significant correlation between any HRV parameter and early stroke outcome in the LAC group. There were different autonomic function properties between LAA and LAC groups, and depressed parasympathetic modulation was associated with worse early outcome in patients with LAA.

Original languageEnglish
Pages (from-to)57-61
Number of pages5
JournalJournal of the Neurological Sciences
Volume314
Issue number1-2
DOIs
Publication statusPublished - Mar 15 2012
Externally publishedYes

Fingerprint

Lacunar Stroke
Infarction
Arteries
Stroke
National Institutes of Health (U.S.)
Heart Rate
Multivariate Analysis
Odds Ratio
Regression Analysis
Confidence Intervals
Control Groups

Keywords

  • Acute ischemic stroke
  • Autonomic function
  • Early outcome
  • Lacunar infarction
  • Large artery atherosclerotic infarction
  • Parasympathetic function

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Parasympathetic activity correlates with early outcome in patients with large artery atherosclerotic stroke. / Chen, Po Lin; Kuo, Terry B J; Yang, Cheryl C H.

In: Journal of the Neurological Sciences, Vol. 314, No. 1-2, 15.03.2012, p. 57-61.

Research output: Contribution to journalArticle

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