Paradoxical cryptococcal immune reconstitution inflammatory syndrome in advanced chronic kidney disease

Chih Chin Kao, Vin Cent Wu, Hsin Yun Sun, Che Hsiung Wu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cryptococcal-related immune reconstitution inflammatory syndrome (IRIS) is frequently seen in immunocompromised patients. A 45-year-old man with advanced chronic kidney disease (CKD) received intensive antifungal treatment for pulmonary cryptococcosis. Despite negative pleural effusion cultures and declining serum cryptococcal antigen titers, the patient presented with progressive pulmonary infiltration, intermittent fever, and elevated C-reactive protein. Steroids were given for suspected IRIS, and the clinical condition improved dramatically. This is the first report on paradoxical cryptococcal IRIS in a patient with advanced CKD.

Original languageEnglish
Pages (from-to)1505-1509
Number of pages5
JournalInternational Urology and Nephrology
Volume45
Issue number5
DOIs
Publication statusPublished - Oct 1 2013
Externally publishedYes

Keywords

  • Chronic kidney disease
  • Cryptococcus
  • Immune reconstitution inflammatory syndrome

ASJC Scopus subject areas

  • Nephrology
  • Urology

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