Panencephalitic Creutzfeldt-Jakob disease unusual presentation of magnetic resonance imaging and proton magnetic resonance spectroscopy

Woei Cherng Shyu, Chau Chin Lee, Yaw Don Hsu, Jiann Chyun Lin, Jiunn Tay Lee, Wei Hwa Lee, Wen Long Tsao

Research output: Contribution to journalArticle

19 Citations (Scopus)


We present serial magnetic resonance imaging (MRI) scans on a biopsy-verified case of Creutzfeldt-Jakob disease (CJD). The initial MRI scan demonstrated increased T2 signal-intensity within the basal ganglia and thalami. Subsequent MRI scans demonstrated a thin cortex, increased T2 signals diffusely within the white matter including U-fibers, and hypointense T2 signals within the basal ganglia, and thalami. Proton magnetic resonance spectroscopy (1H-MRS) study showed an absence of creatine, choline and N-acetylaspartate signals. By these characteristic findings, serial MRI and MRS studies may be helpful in differentiating CJD from other dementing illnesses.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - Jun 1996
Externally publishedYes



  • Basal ganglion
  • Creutzfeldt-Jakob disease
  • Dementia
  • MRI
  • MRS
  • Spongiform encephalopathy

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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