Paclitaxel and carboplatin-induced complete remission in peritoneal carcinomatosis of unknown origin: A report of two cases and review of the literature

Yi Ying Wu, Jang Yang Chang, Tsu Yi Chao

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Peritoneal carcinomatosis is a common evolution of digestive-tract cancer with a poor prognosis.However, a small subgroup unrelated to the digestive tract or any other primary cancer has a relatively better prognosis, especially in women. There are no published data to recommend a treatment regimen for this distinct group. Here we present two women with peritoneal carcinomatosis of unknown origin, who responded to chemotherapy with paclitaxel plus carboplatin. One underwent an exploratory laparotomy and was confirmed to have no residual tumor. The other had complete resolution of ascites and omentum lesions confirmed by radiological examination. Fromthis experience we propose that paclitaxel plus carboplatin is an effective combination regimen for this unique subset of patients. Further prospective trials should be conducted to substantiate this proposal in a larger patient cohort.

Original languageEnglish
Pages (from-to)336-339
Number of pages4
JournalTumori
Volume96
Issue number2
Publication statusPublished - Mar 2010
Externally publishedYes

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Keywords

  • Carboplatin
  • Metastasis of unknown origin
  • Paclitaxel
  • Peritoneal carcinomatosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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