P53 methylation: The Arg-ument is clear

Stephen T. Durant, Er Chieh Cho, Nicholas B. La Thangue

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

p53 activity is of critical importance in suppressing human cancer formation, highlighted by the fact that the majority of human tumors have defective or inactive p53. In normal cells, p53 is held at low levels in a latent form and, following DNA damage, is stabilized which usually results in apoptosis or cell cycle arrest. Most functions of p53 can be ascribed to its role as a sequence specific transcription factor, and an extensive repertoire of downstream responsive genes have been identified. p53 activity is influenced by post-translational modifications, including phosphorylation and lysine methylation. Most recently, arginine methylation mediated by PRMT5, has been identified as an additional and important p53 modification. DNA damage induced p53 arginine methylation impacts on the biochemical properties and functional outcome of the p53 response.

Original languageEnglish
Pages (from-to)801-802
Number of pages2
JournalCell Cycle
Volume8
Issue number6
Publication statusPublished - Mar 15 2009
Externally publishedYes

Keywords

  • Arginine methylation
  • Co-activator
  • DNA damage
  • P53
  • PRMT5

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

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  • Cite this

    Durant, S. T., Cho, E. C., & La Thangue, N. B. (2009). P53 methylation: The Arg-ument is clear. Cell Cycle, 8(6), 801-802.