p27 expression as a prognostic factor of breast cancer in Taiwan

Jan Show Chu, Chiun Sheng Huang, King Jen Chang

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

p27(Kip1) is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. It binds to a variety of cyclin/CDK complexes, inhibits kinase activity, and blocks the cell cycle. Absent or reduced p27 expression has been shown to be a significant predictor of poor survival in breast, colorectal, prostate, non-small cell lung and esophagus carcinomas. An immunohistochemical assay was performed on 169 patients with primary breast cancers to evaluate the biologic significance of p27 expression. Decreased p27 expression was significantly associated with high grade (P=0.00025), negative estrogen receptor (P=0.00004), and negative progesterone receptor (P=0.0038) breast cancers. Univariate analysis reveals that p27 expression inversely correlated significantly with overall survival (P=0.0001). By multivariate analysis, p27 predicted the overall survival independently (P=0.0096). Our study indicates that p27 expression is an independent prognostic marker of breast cancer in Taiwan. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalCancer Letters
Volume141
Issue number1-2
DOIs
Publication statusPublished - Jul 1 1999

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Taiwan
Breast Neoplasms
Survival
Cyclins
Cyclin-Dependent Kinases
Progesterone Receptors
Non-Small Cell Lung Carcinoma
Estrogen Receptors
Esophagus
Prostate
Cell Cycle
Breast
Phosphotransferases
Multivariate Analysis

Keywords

  • Breast cancer
  • Immunohistochemistry
  • p27
  • Proliferating cell neuclear antigen

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

p27 expression as a prognostic factor of breast cancer in Taiwan. / Chu, Jan Show; Huang, Chiun Sheng; Chang, King Jen.

In: Cancer Letters, Vol. 141, No. 1-2, 01.07.1999, p. 123-130.

Research output: Contribution to journalArticle

Chu, Jan Show ; Huang, Chiun Sheng ; Chang, King Jen. / p27 expression as a prognostic factor of breast cancer in Taiwan. In: Cancer Letters. 1999 ; Vol. 141, No. 1-2. pp. 123-130.
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