Oxytocin in schizophrenia: Pathophysiology and implications for future treatment

Kah Kheng Goh; Chun Hsin Chen; Hsien Yuan Lane

doi:10.3390/ijms22042146

Oxytocin in schizophrenia: Pathophysiology and implications for future treatment

Kah Kheng Goh, Chun Hsin Chen, Hsien Yuan Lane

Research output: Contribution to journal › Review article › peer-review

16 Citations (Scopus)

Abstract

Schizophrenia is a form of mental disorder that is behaviorally characterized by abnormal behavior, such as social function deficits or other behaviors that are disconnected from reality. Dysregulation of oxytocin may play a role in regulating the expression of schizophrenia. Given ox-ytocin’s role in social cognition and behavior, a variety of studies have examined the potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. In this review, we highlight the evidence for the role of endogenous oxytocin in schizophrenia, from animal models to human studies. We further discuss the potential of oxytocin as a therapeutic agent for schizophrenia and its implication in future treatment.

Original language	English
Article number	2146
Pages (from-to)	1-26
Number of pages	26
Journal	International journal of molecular sciences
Volume	22
Issue number	4
DOIs	https://doi.org/10.3390/ijms22042146
Publication status	Published - Feb 2 2021

Keywords

Oxytocin
Psychopathology
Schizophrenia
Social cognition

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms22042146

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abstract = "Schizophrenia is a form of mental disorder that is behaviorally characterized by abnormal behavior, such as social function deficits or other behaviors that are disconnected from reality. Dysregulation of oxytocin may play a role in regulating the expression of schizophrenia. Given ox-ytocin{\textquoteright}s role in social cognition and behavior, a variety of studies have examined the potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. In this review, we highlight the evidence for the role of endogenous oxytocin in schizophrenia, from animal models to human studies. We further discuss the potential of oxytocin as a therapeutic agent for schizophrenia and its implication in future treatment.",

keywords = "Oxytocin, Psychopathology, Schizophrenia, Social cognition",

author = "Goh, {Kah Kheng} and Chen, {Chun Hsin} and Lane, {Hsien Yuan}",

note = "Funding Information: Funding: The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: this study was supported by the Wan-Fang Hospital, Taipei Medical University (110-eva-13); the Higher Education Sprout Project by the Ministry of Education; the Ministry of Science and Technology (MOST108-2314-B-038-077, MOST109-2314-B-038-084, MOST109-2314-B-038-023-MY2), Taiwan; China Medical University (CMU109-MOST-03). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

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N1 - Funding Information: Funding: The authors disclose receipt of the following financial support for the research, authorship, and/or publication of this article: this study was supported by the Wan-Fang Hospital, Taipei Medical University (110-eva-13); the Higher Education Sprout Project by the Ministry of Education; the Ministry of Science and Technology (MOST108-2314-B-038-077, MOST109-2314-B-038-084, MOST109-2314-B-038-023-MY2), Taiwan; China Medical University (CMU109-MOST-03). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - Schizophrenia is a form of mental disorder that is behaviorally characterized by abnormal behavior, such as social function deficits or other behaviors that are disconnected from reality. Dysregulation of oxytocin may play a role in regulating the expression of schizophrenia. Given ox-ytocin’s role in social cognition and behavior, a variety of studies have examined the potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. In this review, we highlight the evidence for the role of endogenous oxytocin in schizophrenia, from animal models to human studies. We further discuss the potential of oxytocin as a therapeutic agent for schizophrenia and its implication in future treatment.

AB - Schizophrenia is a form of mental disorder that is behaviorally characterized by abnormal behavior, such as social function deficits or other behaviors that are disconnected from reality. Dysregulation of oxytocin may play a role in regulating the expression of schizophrenia. Given ox-ytocin’s role in social cognition and behavior, a variety of studies have examined the potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. In this review, we highlight the evidence for the role of endogenous oxytocin in schizophrenia, from animal models to human studies. We further discuss the potential of oxytocin as a therapeutic agent for schizophrenia and its implication in future treatment.

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KW - Psychopathology

KW - Schizophrenia

KW - Social cognition

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Oxytocin in schizophrenia: Pathophysiology and implications for future treatment

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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