Oxytocin in schizophrenia: Pathophysiology and implications for future treatment

Kah Kheng Goh, Chun Hsin Chen, Hsien Yuan Lane

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)


Schizophrenia is a form of mental disorder that is behaviorally characterized by abnormal behavior, such as social function deficits or other behaviors that are disconnected from reality. Dysregulation of oxytocin may play a role in regulating the expression of schizophrenia. Given ox-ytocin’s role in social cognition and behavior, a variety of studies have examined the potential clinical benefits of oxytocin in improving the psychopathology of patients with schizophrenia. In this review, we highlight the evidence for the role of endogenous oxytocin in schizophrenia, from animal models to human studies. We further discuss the potential of oxytocin as a therapeutic agent for schizophrenia and its implication in future treatment.

Original languageEnglish
Article number2146
Pages (from-to)1-26
Number of pages26
JournalInternational journal of molecular sciences
Issue number4
Publication statusPublished - Feb 2 2021


  • Oxytocin
  • Psychopathology
  • Schizophrenia
  • Social cognition

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry


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