Oxidative stress status in recently abstinent methamphetamine abusers

Ming Chyi Huang, Shih Ku Lin, Chun Hsin Chen, Chun Hung Pan, Chao Hui Lee, Hsing Cheng Liu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim Methamphetamine (METH) administration is associated with excessive oxidative stress. It is not known whether the systemic oxidative stress indices would alter during early abstinence in METH abusers with positive urine testing for recent METH exposure. Methods Sixty-four non-treatment-seeking METH abusers enrolled from a controlled environment and 60 healthy controls participated in the study. Fasting serum malondialdehyde (MDA) levels and anti-oxidant indices, including superoxide dismutase (SOD) and catalase (CAT) activity, and glutathione (GSH) levels, were measured at baseline and 2 weeks after the first measurement. We compared the differences of these oxidative stress indices between METH abusers and controls and examined the changes of the indices 2 weeks after baseline in the METH group. Results At baseline, the recently abstinent METH abusers had significantly higher MDA levels, lower SOD activity, and higher CAT activity and GSH levels compared to healthy controls. CAT and GSH values were positively correlated with MDA but negatively correlated with SOD. These oxidative stress indices did not significantly correlate with age, smoking amount, Alcohol Use Disorder Identification Test scores, or METH use variables. After 2 more weeks of abstinence, the indices did not alter nor normalize. Conclusion Compared to controls, we found that METH abusers have persistently higher systemic oxidative stress throughout early abstinence. The compromised SOD as well as elevated CAT activity and GSH levels may act together as a compensatory mechanism to counteract excessive oxidative stress induced by METH. Whether the oxidative stress could improve after a longer period of abstinence needs to be examined in future studies.

Original languageEnglish
Pages (from-to)92-100
Number of pages9
JournalPsychiatry and Clinical Neurosciences
Volume67
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Methamphetamine
Oxidative Stress
Catalase
Superoxide Dismutase
Malondialdehyde
Controlled Environment
Oxidants
Glutathione
Fasting
Smoking
Alcohols
Urine

Keywords

  • abstinence
  • anti-oxidant
  • malondialdehyde
  • methamphetamine
  • oxidative stress

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Psychiatry and Mental health
  • Neuroscience(all)

Cite this

Oxidative stress status in recently abstinent methamphetamine abusers. / Huang, Ming Chyi; Lin, Shih Ku; Chen, Chun Hsin; Pan, Chun Hung; Lee, Chao Hui; Liu, Hsing Cheng.

In: Psychiatry and Clinical Neurosciences, Vol. 67, No. 2, 02.2013, p. 92-100.

Research output: Contribution to journalArticle

Huang, Ming Chyi ; Lin, Shih Ku ; Chen, Chun Hsin ; Pan, Chun Hung ; Lee, Chao Hui ; Liu, Hsing Cheng. / Oxidative stress status in recently abstinent methamphetamine abusers. In: Psychiatry and Clinical Neurosciences. 2013 ; Vol. 67, No. 2. pp. 92-100.
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abstract = "Aim Methamphetamine (METH) administration is associated with excessive oxidative stress. It is not known whether the systemic oxidative stress indices would alter during early abstinence in METH abusers with positive urine testing for recent METH exposure. Methods Sixty-four non-treatment-seeking METH abusers enrolled from a controlled environment and 60 healthy controls participated in the study. Fasting serum malondialdehyde (MDA) levels and anti-oxidant indices, including superoxide dismutase (SOD) and catalase (CAT) activity, and glutathione (GSH) levels, were measured at baseline and 2 weeks after the first measurement. We compared the differences of these oxidative stress indices between METH abusers and controls and examined the changes of the indices 2 weeks after baseline in the METH group. Results At baseline, the recently abstinent METH abusers had significantly higher MDA levels, lower SOD activity, and higher CAT activity and GSH levels compared to healthy controls. CAT and GSH values were positively correlated with MDA but negatively correlated with SOD. These oxidative stress indices did not significantly correlate with age, smoking amount, Alcohol Use Disorder Identification Test scores, or METH use variables. After 2 more weeks of abstinence, the indices did not alter nor normalize. Conclusion Compared to controls, we found that METH abusers have persistently higher systemic oxidative stress throughout early abstinence. The compromised SOD as well as elevated CAT activity and GSH levels may act together as a compensatory mechanism to counteract excessive oxidative stress induced by METH. Whether the oxidative stress could improve after a longer period of abstinence needs to be examined in future studies.",
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