Oxidative stress on pulmonary vein and left atrium arrhythmogenesis

Yung Kuo Lin, Feng Zhi Lin, Yao Chang Chen, Chen Chuan Cheng, Cheng I. Lin, Yi Jen Chen, Shih Ann Chen

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background: Oxidative stress and pulmonary veins (PVs) play critical roles in the pathophysiology of atrial fibrillation. The purpose of the present study was to investigate whether oxidative stress and antioxidant agents can change the electrophysiological characteristics of the left atrium (LA) and PVs.&Methods and Results: Conventional microelectrodes were used to record the action potentials (APs) in isolated rabbit PV and LA specimens before and after H2O2 administration with or without ascorbic acid or N-mercaptopro-pionylglycine (N-MPG, a free radical ·OH scavenger). H2O2 (0.02 and 0.2mmol/L) decreased the PV spontaneous rates from 2.0±0.1 Hz to 1.6±0.1 Hz, and 1.7±0.1 Hz (n=10, P

Original languageEnglish
Pages (from-to)1547-1556
Number of pages10
JournalCirculation Journal
Volume74
Issue number8
DOIs
Publication statusPublished - 2010

Fingerprint

Pulmonary Veins
Heart Atria
Oxidative Stress
Free Radical Scavengers
Microelectrodes
Atrial Fibrillation
Action Potentials
Ascorbic Acid
Antioxidants
Rabbits

Keywords

  • Antioxidant
  • Atrial fibrillation
  • Hydrogen peroxide
  • Pulmonary vein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Oxidative stress on pulmonary vein and left atrium arrhythmogenesis. / Lin, Yung Kuo; Lin, Feng Zhi; Chen, Yao Chang; Cheng, Chen Chuan; Lin, Cheng I.; Chen, Yi Jen; Chen, Shih Ann.

In: Circulation Journal, Vol. 74, No. 8, 2010, p. 1547-1556.

Research output: Contribution to journalArticle

Lin, Yung Kuo ; Lin, Feng Zhi ; Chen, Yao Chang ; Cheng, Chen Chuan ; Lin, Cheng I. ; Chen, Yi Jen ; Chen, Shih Ann. / Oxidative stress on pulmonary vein and left atrium arrhythmogenesis. In: Circulation Journal. 2010 ; Vol. 74, No. 8. pp. 1547-1556.
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AU - Chen, Yi Jen

AU - Chen, Shih Ann

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