Oxidative stress on pulmonary vein and left atrium arrhythmogenesis

Yung Kuo Lin, Feng Zhi Lin, Yao Chang Chen, Chen Chuan Cheng, Cheng I. Lin, Yi Jen Chen, Shih Ann Chen

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35 Citations (Scopus)

Abstract

Background: Oxidative stress and pulmonary veins (PVs) play critical roles in the pathophysiology of atrial fibrillation. The purpose of the present study was to investigate whether oxidative stress and antioxidant agents can change the electrophysiological characteristics of the left atrium (LA) and PVs.&Methods and Results: Conventional microelectrodes were used to record the action potentials (APs) in isolated rabbit PV and LA specimens before and after H2O2 administration with or without ascorbic acid or N-mercaptopro-pionylglycine (N-MPG, a free radical ·OH scavenger). H2O2 (0.02 and 0.2mmol/L) decreased the PV spontaneous rates from 2.0±0.1 Hz to 1.6±0.1 Hz, and 1.7±0.1 Hz (n=10, P

Original languageEnglish
Pages (from-to)1547-1556
Number of pages10
JournalCirculation Journal
Volume74
Issue number8
DOIs
Publication statusPublished - 2010

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Keywords

  • Antioxidant
  • Atrial fibrillation
  • Hydrogen peroxide
  • Pulmonary vein

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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