Oxidative stress in patients with Graves' ophthalmopathy: Relationship between oxidative DNA damage and clinical evolution

C. C. Tsai, C. Y. Cheng, C. Y. Liu, S. C. Kao, H. C. Kau, W. M. Hsu, Y. H. Wei

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

Purpose: To evaluate the relationship between oxidative stress and clinical evolution in patients with Graves' ophthalmopathy (GO). Methods: Thirty-one euthyroid GO patients and 25 healthy subjects participated in this study. Oxidative DNA damage was assessed by determination of the 8-hydroxy-2′- deoxyguanosine (8-OHdG) level in urine by ELISA. The relationship of oxidative DNA damage to the clinical evolutions of GO, especially the smoking status, clinical activity scores (CAS), and ophthalmopathy index was examined. Results: The mean 8-OHdG was significantly higher in GO patients than that of normal controls (12.6 ± 5.7 vs 6.7 ± 2.5 ng/mg creatinine, P3) had higher 8-OHdG than did the patients with CAS≤3 (16.3 ± 4.9 vs 8.6 ± 3.0 ng/mg creatinine). Conclusions: Our findings suggest that urinary 8-OHdG is increased in GO patients and is correlated with the disease activity. Smoking had a higher impact on the increased 8-OHdG among GO patients.

Original languageEnglish
Pages (from-to)1725-1730
Number of pages6
JournalEye
Volume23
Issue number8
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Graves' ophthalmopathy
  • Oxidative DNA damage
  • Oxidative stress

ASJC Scopus subject areas

  • Ophthalmology

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