Overlapping nongenomic and genomic actions of thyroid hormone and steroids

Paul J. Davis, Hung Yun Lin, Shaker A. Mousa, Mary K. Luidens, Aleck A. Hercbergs, Martin Wehling, Faith B. Davis

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Nuclear receptors for thyroid hormone and steroids are members of a receptor superfamily with similar molecular organization, but discrete transcriptional functions that define genomic actions of these nonpeptide hormones. Nongenomic actions of thyroid hormone and estrogens and androgens are initiated outside the nucleus, at receptors in the plasma membrane or in cytoplasm; these actions are largely regarded to be unique to the respective hormones. However, there is an increasing number of descriptions of overlapping nongenomic and genomic effects of thyroid hormone and estrogens and testosterone. These effects are concentrated in tumor cells, where, for example, estrogens and thyroid hormone have similar mitogen-activate protein kinase (MAPK)-dependent proliferative actions on ERα-positive human breast cancer cells, and where dihydrotestosterone also can stimulate proliferation. Steroids and thyroid hormone have similar anti-apoptotic effects in certain tumors. But thyroid hormone and steroids also have overlapping or interacting nongenomic and genomic actions in heart and brain cells. These various effects of thyroid hormone and estrogens and androgens are reviewed here and their possible clinical consequences are enumerated.

Original languageEnglish
Pages (from-to)829-833
Number of pages5
JournalSteroids
Volume76
Issue number9
DOIs
Publication statusPublished - Aug 2011
Externally publishedYes

Fingerprint

Thyroid Hormones
Steroids
Estrogens
Androgens
Tumors
Steroid hormones
Cells
Hormones
Dihydrotestosterone
Cell membranes
Cytoplasmic and Nuclear Receptors
Mitogens
Protein Kinases
Testosterone
Brain
Neoplasms
Cytoplasm
Cell Membrane
Breast Neoplasms

Keywords

  • 3,5,3′-Triiodo-L-thyronine
  • Estrogens
  • Testosterone
  • Thyroxine

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Molecular Biology
  • Organic Chemistry
  • Pharmacology

Cite this

Davis, P. J., Lin, H. Y., Mousa, S. A., Luidens, M. K., Hercbergs, A. A., Wehling, M., & Davis, F. B. (2011). Overlapping nongenomic and genomic actions of thyroid hormone and steroids. Steroids, 76(9), 829-833. https://doi.org/10.1016/j.steroids.2011.02.012

Overlapping nongenomic and genomic actions of thyroid hormone and steroids. / Davis, Paul J.; Lin, Hung Yun; Mousa, Shaker A.; Luidens, Mary K.; Hercbergs, Aleck A.; Wehling, Martin; Davis, Faith B.

In: Steroids, Vol. 76, No. 9, 08.2011, p. 829-833.

Research output: Contribution to journalReview article

Davis, PJ, Lin, HY, Mousa, SA, Luidens, MK, Hercbergs, AA, Wehling, M & Davis, FB 2011, 'Overlapping nongenomic and genomic actions of thyroid hormone and steroids', Steroids, vol. 76, no. 9, pp. 829-833. https://doi.org/10.1016/j.steroids.2011.02.012
Davis PJ, Lin HY, Mousa SA, Luidens MK, Hercbergs AA, Wehling M et al. Overlapping nongenomic and genomic actions of thyroid hormone and steroids. Steroids. 2011 Aug;76(9):829-833. https://doi.org/10.1016/j.steroids.2011.02.012
Davis, Paul J. ; Lin, Hung Yun ; Mousa, Shaker A. ; Luidens, Mary K. ; Hercbergs, Aleck A. ; Wehling, Martin ; Davis, Faith B. / Overlapping nongenomic and genomic actions of thyroid hormone and steroids. In: Steroids. 2011 ; Vol. 76, No. 9. pp. 829-833.
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