Overexpression of the PSAT1 gene in nasopharyngeal carcinoma is an indicator of poor prognosis

Kuang Ming Liao, Tung Bo Chao, Yu Feng Tian, Ching Yih Lin, Sung Wei Lee, Hua Ying Chuang, Ti Chun Chan, Tzu Ju Chen, Chung Hsi Hsing, Ming Jen Sheu, Chien Feng Li

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16 Citations (Scopus)

Abstract

Purpose: Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and Southeast Asia, but risk stratification and treatment outcome in NPC patients remain suboptimal. Our study identified and validated metabolic drivers that are relevant to the pathogenesis of NPC using a published transcriptome. Phosphoserine aminotransferase 1 (PSAT1) is an enzyme that is involved in serine biosynthesis, and its overexpression is associated with colon cancer, non-small cell lung cancer and breast cancer. However, its expression has not been systemically evaluated in patients with NPC. Materials and Methods: We evaluated two public transcriptomes of NPC tissues and benign nasopharyngeal mucosal epithelial tissues that deposited in the NIH Gene Expression Omnibus database under accession number GSE34574 and GSE12452. We also performed immunohistochemical staining and assessment of PSAT1 in a total of 124 NPC patients received radiotherapy and were regularly followed-up until death or loss. The endpoints analyzed were local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), disease-specific survival (DSS), and overall survival (OS). Results: We retrospectively evaluated 124 patients with NPC and found that high PSAT1 expression was associated with poor prognosis of NPC and indicator of advanced tumor stage. High PSAT1 expression also correlated with an aggressive clinical course, with significantly shorter DSS (HR= 2.856, 95% CI 1.599 to 5.101), DMFS (HR= 3.305, 95% CI 1.720 to 6.347), LRFS (HR= 2.834, 95% CI 1.376 to 5.835), and OS HR= 2.935, 95% CI 1.646-5.234) in multivariate analyses. Conclusions: Our study showed that PSAT1 is a potential prognostic biomarker and higher expression of PSAT1 is associated with a poor prognosis in NPC.

Original languageEnglish
Pages (from-to)1088-1094
Number of pages7
JournalJournal of Cancer
Volume7
Issue number9
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Nasopharyngeal carcinoma
  • Prognosis
  • PSAT1

ASJC Scopus subject areas

  • Oncology

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    Liao, K. M., Chao, T. B., Tian, Y. F., Lin, C. Y., Lee, S. W., Chuang, H. Y., Chan, T. C., Chen, T. J., Hsing, C. H., Sheu, M. J., & Li, C. F. (2016). Overexpression of the PSAT1 gene in nasopharyngeal carcinoma is an indicator of poor prognosis. Journal of Cancer, 7(9), 1088-1094. https://doi.org/10.7150/jca.15258