Abstract
Background. Gastric carcinoma is one of the most common malignancies in the world, yet little is known about the molecular process of its development and progression. The aims of this study are to correlate the expression of nuclear protein kinase CK2β subunit (CK2β) with clinicopathologic parameters and patient survival. Methods. Expression levels of nuclear CK2β were analyzed in 104 gastric tissues from patients with gastric carcinoma by immunohistochemistry. A paired t test was used to analyze the differences in nuclear CK2β expression between tumor and nontumor tissues in the same patient. A two-tailed v2 test was performed to determine the significance of the difference between nuclear CK2β expression and clinicopathologic parameters. All time-to-event endpoints according to various clinicopathologic parameters were plotted by Kaplan-Meier method, and significance was then determined by univariate log-rank test. Cox proportional-hazards model was used for multivariate analysis to determine the independence of prognostic impact of nuclear CK2β expression. Results. Overexpression of nuclear CK2β was significantly correlated with depth of invasion (P = 0.042). Patients with high expression levels of nuclear CK2β had a significantly poorer overall survival rate compared with patients with low expression levels of nuclear CK2β (P = 0.0006). On multivariate Cox regression analysis, overexpression of nuclear CK2β and stage were proven to be independent prognostic markers for gastric carcinoma (P = 0.0036 and 0.0005, respectively). Conclusions. Overexpression of nuclear CK2β can be a useful marker for predicting the outcome of patients with gastric carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 1695-1702 |
| Number of pages | 8 |
| Journal | Annals of Surgical Oncology |
| Volume | 17 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2010 |
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ASJC Scopus subject areas
- Surgery
- Oncology
Cite this
Overexpression of nuclear protein kinase CK2 β subunit and prognosis in human gastric carcinoma. / Lin, Kai Yuan; Fang, Chia Lang; Chen, Yi; Li, Chien Feng; Chen, Sheng-Hsuan; Kuo, Chen Yi; Tai, Chein; Uen, Yih Huei.
In: Annals of Surgical Oncology, Vol. 17, No. 6, 06.2010, p. 1695-1702.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Overexpression of nuclear protein kinase CK2 β subunit and prognosis in human gastric carcinoma
AU - Lin, Kai Yuan
AU - Fang, Chia Lang
AU - Chen, Yi
AU - Li, Chien Feng
AU - Chen, Sheng-Hsuan
AU - Kuo, Chen Yi
AU - Tai, Chein
AU - Uen, Yih Huei
PY - 2010/6
Y1 - 2010/6
N2 - Background. Gastric carcinoma is one of the most common malignancies in the world, yet little is known about the molecular process of its development and progression. The aims of this study are to correlate the expression of nuclear protein kinase CK2β subunit (CK2β) with clinicopathologic parameters and patient survival. Methods. Expression levels of nuclear CK2β were analyzed in 104 gastric tissues from patients with gastric carcinoma by immunohistochemistry. A paired t test was used to analyze the differences in nuclear CK2β expression between tumor and nontumor tissues in the same patient. A two-tailed v2 test was performed to determine the significance of the difference between nuclear CK2β expression and clinicopathologic parameters. All time-to-event endpoints according to various clinicopathologic parameters were plotted by Kaplan-Meier method, and significance was then determined by univariate log-rank test. Cox proportional-hazards model was used for multivariate analysis to determine the independence of prognostic impact of nuclear CK2β expression. Results. Overexpression of nuclear CK2β was significantly correlated with depth of invasion (P = 0.042). Patients with high expression levels of nuclear CK2β had a significantly poorer overall survival rate compared with patients with low expression levels of nuclear CK2β (P = 0.0006). On multivariate Cox regression analysis, overexpression of nuclear CK2β and stage were proven to be independent prognostic markers for gastric carcinoma (P = 0.0036 and 0.0005, respectively). Conclusions. Overexpression of nuclear CK2β can be a useful marker for predicting the outcome of patients with gastric carcinoma.
AB - Background. Gastric carcinoma is one of the most common malignancies in the world, yet little is known about the molecular process of its development and progression. The aims of this study are to correlate the expression of nuclear protein kinase CK2β subunit (CK2β) with clinicopathologic parameters and patient survival. Methods. Expression levels of nuclear CK2β were analyzed in 104 gastric tissues from patients with gastric carcinoma by immunohistochemistry. A paired t test was used to analyze the differences in nuclear CK2β expression between tumor and nontumor tissues in the same patient. A two-tailed v2 test was performed to determine the significance of the difference between nuclear CK2β expression and clinicopathologic parameters. All time-to-event endpoints according to various clinicopathologic parameters were plotted by Kaplan-Meier method, and significance was then determined by univariate log-rank test. Cox proportional-hazards model was used for multivariate analysis to determine the independence of prognostic impact of nuclear CK2β expression. Results. Overexpression of nuclear CK2β was significantly correlated with depth of invasion (P = 0.042). Patients with high expression levels of nuclear CK2β had a significantly poorer overall survival rate compared with patients with low expression levels of nuclear CK2β (P = 0.0006). On multivariate Cox regression analysis, overexpression of nuclear CK2β and stage were proven to be independent prognostic markers for gastric carcinoma (P = 0.0036 and 0.0005, respectively). Conclusions. Overexpression of nuclear CK2β can be a useful marker for predicting the outcome of patients with gastric carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=77954818595&partnerID=8YFLogxK
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U2 - 10.1245/s10434-010-0911-9
DO - 10.1245/s10434-010-0911-9
M3 - Article
C2 - 20087779
AN - SCOPUS:77954818595
VL - 17
SP - 1695
EP - 1702
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
SN - 1068-9265
IS - 6
ER -