Overexpression of JAK2

A predictor of unfavorable prognosis for nasopharyngeal carcinoma

Hong Lin He, Ying En Lee, Peir In Liang, Sung Wei Lee, Tzu Ju Chen, Ti Chun Chan, Chung Hsi Hsing, I. Wei Chang, Yow Ling Shiue, Chien Feng Li

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.

Original languageEnglish
Pages (from-to)1887-1896
Number of pages10
JournalFuture Oncology
Volume12
Issue number16
DOIs
Publication statusPublished - Aug 1 2016
Externally publishedYes

Fingerprint

Mutation
Neoplasm Staging
Transcriptome
Neoplasm Metastasis
Recurrence
Polymerase Chain Reaction
Neoplasms
Proteins
Nasopharyngeal carcinoma
Therapeutics

Keywords

  • JAK2
  • Janus kinase
  • nasopharyngeal carcinoma
  • prognosis
  • transcriptome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

He, H. L., Lee, Y. E., Liang, P. I., Lee, S. W., Chen, T. J., Chan, T. C., ... Li, C. F. (2016). Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma. Future Oncology, 12(16), 1887-1896. https://doi.org/10.2217/fon-2016-0025

Overexpression of JAK2 : A predictor of unfavorable prognosis for nasopharyngeal carcinoma. / He, Hong Lin; Lee, Ying En; Liang, Peir In; Lee, Sung Wei; Chen, Tzu Ju; Chan, Ti Chun; Hsing, Chung Hsi; Chang, I. Wei; Shiue, Yow Ling; Li, Chien Feng.

In: Future Oncology, Vol. 12, No. 16, 01.08.2016, p. 1887-1896.

Research output: Contribution to journalArticle

He, HL, Lee, YE, Liang, PI, Lee, SW, Chen, TJ, Chan, TC, Hsing, CH, Chang, IW, Shiue, YL & Li, CF 2016, 'Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma', Future Oncology, vol. 12, no. 16, pp. 1887-1896. https://doi.org/10.2217/fon-2016-0025
He, Hong Lin ; Lee, Ying En ; Liang, Peir In ; Lee, Sung Wei ; Chen, Tzu Ju ; Chan, Ti Chun ; Hsing, Chung Hsi ; Chang, I. Wei ; Shiue, Yow Ling ; Li, Chien Feng. / Overexpression of JAK2 : A predictor of unfavorable prognosis for nasopharyngeal carcinoma. In: Future Oncology. 2016 ; Vol. 12, No. 16. pp. 1887-1896.
@article{63b217c88fb14b999f1663f6a5f4aed5,
title = "Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma",
abstract = "Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.",
keywords = "JAK2, Janus kinase, nasopharyngeal carcinoma, prognosis, transcriptome",
author = "He, {Hong Lin} and Lee, {Ying En} and Liang, {Peir In} and Lee, {Sung Wei} and Chen, {Tzu Ju} and Chan, {Ti Chun} and Hsing, {Chung Hsi} and Chang, {I. Wei} and Shiue, {Yow Ling} and Li, {Chien Feng}",
year = "2016",
month = "8",
day = "1",
doi = "10.2217/fon-2016-0025",
language = "English",
volume = "12",
pages = "1887--1896",
journal = "Future Science OA",
issn = "1479-6694",
publisher = "Future Medicine Ltd.",
number = "16",

}

TY - JOUR

T1 - Overexpression of JAK2

T2 - A predictor of unfavorable prognosis for nasopharyngeal carcinoma

AU - He, Hong Lin

AU - Lee, Ying En

AU - Liang, Peir In

AU - Lee, Sung Wei

AU - Chen, Tzu Ju

AU - Chan, Ti Chun

AU - Hsing, Chung Hsi

AU - Chang, I. Wei

AU - Shiue, Yow Ling

AU - Li, Chien Feng

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.

AB - Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.

KW - JAK2

KW - Janus kinase

KW - nasopharyngeal carcinoma

KW - prognosis

KW - transcriptome

UR - http://www.scopus.com/inward/record.url?scp=84979508776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84979508776&partnerID=8YFLogxK

U2 - 10.2217/fon-2016-0025

DO - 10.2217/fon-2016-0025

M3 - Article

VL - 12

SP - 1887

EP - 1896

JO - Future Science OA

JF - Future Science OA

SN - 1479-6694

IS - 16

ER -