Overexpression of JAK2: A predictor of unfavorable prognosis for nasopharyngeal carcinoma

Hong Lin He, Ying En Lee, Peir In Liang, Sung Wei Lee, Tzu Ju Chen, Ti Chun Chan, Chung Hsi Hsing, I. Wei Chang, Yow Ling Shiue, Chien Feng Li

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: Analysis of the nasopharyngeal carcinoma public transcriptome revealed JAK2 was significantly upregulated in tumors, which encouraged us to investigate its prognostic significance and mutational status. Materials & methods: We assessed the immune-expression of JAK2 and its relationships with various clinicopathological parameters. JAK2 mutation was detected by PCR followed by sequencing. Results: High expression of JAK2 was significantly associated with advanced tumor staging (p = 0.019). JAK2 overexpression acted as an independent predictor for worse disease-specific survival (p = 0.005), distant metastasis-free survival (p = 0.036), local recurrence-free survival (p = 0.012) and overall survival (p = 0.007). JAK2 mutation was not detected in selected cases with JAK2 protein overexpression. Conclusion: JAK2 can serve as a valuable negative prognostic factor and a potential therapeutic target.

Original languageEnglish
Pages (from-to)1887-1896
Number of pages10
JournalFuture Oncology
Volume12
Issue number16
DOIs
Publication statusPublished - Aug 1 2016
Externally publishedYes

Keywords

  • JAK2
  • Janus kinase
  • nasopharyngeal carcinoma
  • prognosis
  • transcriptome

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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